Abstract
The effect of D-Ala2-Leu5-Arg6-enkephalin on catecholamines excretion in urine, their content and monoamine oxidase activity in rats with acute myocardial ischemia, was studied. Enkephalins were found to promote the inhibition of unadequate hyperfunction of sympathetic-adrenal system at early stages of myocardial infarction and to favour the exhaustion prophylaxis of accumulated precursors of catecholamines biosynthesis. The above-mentioned effects are realized owing to peptidergic inhibition of enzymes that catalize dioxyphenylalanine and dopamine biotransformation to noradrenalin and adrenalin, with subsequent increase in dioxyphenylalanine synthesis. The effect of catecholamines is also achieved because of their ability to decrease release and to increase reverse neuronal seizure of monoamines that leads to maintenance and faster restoration of catecholamines' level in adrenergic structures in stress.
| Original language | English |
|---|---|
| Pages (from-to) | 77-85 |
| Number of pages | 9 |
| Journal | Fiziologicheskii Zhurnal SSSR Imeni I.M. Sechenova |
| Volume | 81 |
| Issue number | 5 |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Physiology
Cite this
Interaction of opioid and sympathetic-adrenal systems in ischemic heart damage. / Lishmanov Yu., B.; Kondratyev Yu., B.
In: Fiziologicheskii Zhurnal SSSR Imeni I.M. Sechenova, Vol. 81, No. 5, 1995, p. 77-85.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interaction of opioid and sympathetic-adrenal systems in ischemic heart damage
AU - Lishmanov Yu., B.
AU - Kondratyev Yu., B.
PY - 1995
Y1 - 1995
N2 - The effect of D-Ala2-Leu5-Arg6-enkephalin on catecholamines excretion in urine, their content and monoamine oxidase activity in rats with acute myocardial ischemia, was studied. Enkephalins were found to promote the inhibition of unadequate hyperfunction of sympathetic-adrenal system at early stages of myocardial infarction and to favour the exhaustion prophylaxis of accumulated precursors of catecholamines biosynthesis. The above-mentioned effects are realized owing to peptidergic inhibition of enzymes that catalize dioxyphenylalanine and dopamine biotransformation to noradrenalin and adrenalin, with subsequent increase in dioxyphenylalanine synthesis. The effect of catecholamines is also achieved because of their ability to decrease release and to increase reverse neuronal seizure of monoamines that leads to maintenance and faster restoration of catecholamines' level in adrenergic structures in stress.
AB - The effect of D-Ala2-Leu5-Arg6-enkephalin on catecholamines excretion in urine, their content and monoamine oxidase activity in rats with acute myocardial ischemia, was studied. Enkephalins were found to promote the inhibition of unadequate hyperfunction of sympathetic-adrenal system at early stages of myocardial infarction and to favour the exhaustion prophylaxis of accumulated precursors of catecholamines biosynthesis. The above-mentioned effects are realized owing to peptidergic inhibition of enzymes that catalize dioxyphenylalanine and dopamine biotransformation to noradrenalin and adrenalin, with subsequent increase in dioxyphenylalanine synthesis. The effect of catecholamines is also achieved because of their ability to decrease release and to increase reverse neuronal seizure of monoamines that leads to maintenance and faster restoration of catecholamines' level in adrenergic structures in stress.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029557461&partnerID=8YFLogxK
M3 - Article
VL - 81
SP - 77
EP - 85
JO - Fiziologicheskii Zhurnal Imeni I.M. Sechenova
JF - Fiziologicheskii Zhurnal Imeni I.M. Sechenova
SN - 0869-8139
IS - 5
ER -