Působení genotoxického 2-nitrofluorenu a jeho metabolitů na DNA in vivo a sledování tohoto působení pomocí elektrochemických DNA biosenzorů in vitro

Translated title of the contribution: Interaction of genotoxic 2-nitrofluorene and its metabolites with DNA in vivo and its monitoring using electrochemical DNA biosensors in vitro

Štěpánka Skalová, Klára Stávková, Andrea Hájková, Jiří Barek, Jan Fischer, Joseph Wang, Vlastimil Vyskočil

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This review is focused on genotoxic 2-nitrofluorene, which is a marker for the presence of nitrated polycyclic aromatic hydrocarbons, and summarizes the current knowledge about the negative effects of 2-nitrofluorene and its metabolites on living organisms, especially on their DNA. These findings obtained via in vivo investigations are compared with information obtained using electrochemical DNA biosensors, which represent very promising in vitro alternative to the study of processes proceeding in living organisms during the interaction of their DNA with various xenobiotic compounds.

Original languageCzech
Pages (from-to)178-185
Number of pages8
JournalChemicke Listy
Volume111
Issue number3
Publication statusPublished - 1 Mar 2017
Externally publishedYes

Fingerprint

Metabolites
Biosensors
Monitoring
DNA
Polycyclic Aromatic Hydrocarbons
Xenobiotics
2-nitrofluorene

Keywords

  • 2-nitrofluorene
  • Carbon electrodes
  • DNA adducts
  • DNA biosensors
  • DNA damage detection
  • Mercury electrodes
  • Nitrated polycyclic aromatic hydrocarbons

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Působení genotoxického 2-nitrofluorenu a jeho metabolitů na DNA in vivo a sledování tohoto působení pomocí elektrochemických DNA biosenzorů in vitro. / Skalová, Štěpánka; Stávková, Klára; Hájková, Andrea; Barek, Jiří; Fischer, Jan; Wang, Joseph; Vyskočil, Vlastimil.

In: Chemicke Listy, Vol. 111, No. 3, 01.03.2017, p. 178-185.

Research output: Contribution to journalArticle

Skalová, Štěpánka ; Stávková, Klára ; Hájková, Andrea ; Barek, Jiří ; Fischer, Jan ; Wang, Joseph ; Vyskočil, Vlastimil. / Působení genotoxického 2-nitrofluorenu a jeho metabolitů na DNA in vivo a sledování tohoto působení pomocí elektrochemických DNA biosenzorů in vitro. In: Chemicke Listy. 2017 ; Vol. 111, No. 3. pp. 178-185.
@article{c11cf7283e7c4815bcbcf49f40c9b1f7,
title = "Působen{\'i} genotoxick{\'e}ho 2-nitrofluorenu a jeho metabolitů na DNA in vivo a sledov{\'a}n{\'i} tohoto působen{\'i} pomoc{\'i} elektrochemick{\'y}ch DNA biosenzorů in vitro",
abstract = "This review is focused on genotoxic 2-nitrofluorene, which is a marker for the presence of nitrated polycyclic aromatic hydrocarbons, and summarizes the current knowledge about the negative effects of 2-nitrofluorene and its metabolites on living organisms, especially on their DNA. These findings obtained via in vivo investigations are compared with information obtained using electrochemical DNA biosensors, which represent very promising in vitro alternative to the study of processes proceeding in living organisms during the interaction of their DNA with various xenobiotic compounds.",
keywords = "2-nitrofluorene, Carbon electrodes, DNA adducts, DNA biosensors, DNA damage detection, Mercury electrodes, Nitrated polycyclic aromatic hydrocarbons",
author = "Štěp{\'a}nka Skalov{\'a} and Kl{\'a}ra St{\'a}vkov{\'a} and Andrea H{\'a}jkov{\'a} and Jiř{\'i} Barek and Jan Fischer and Joseph Wang and Vlastimil Vyskočil",
year = "2017",
month = "3",
day = "1",
language = "Czech",
volume = "111",
pages = "178--185",
journal = "Chemicke Listy",
issn = "0009-2770",
publisher = "Czech Society of Chemical Engineering",
number = "3",

}

TY - JOUR

T1 - Působení genotoxického 2-nitrofluorenu a jeho metabolitů na DNA in vivo a sledování tohoto působení pomocí elektrochemických DNA biosenzorů in vitro

AU - Skalová, Štěpánka

AU - Stávková, Klára

AU - Hájková, Andrea

AU - Barek, Jiří

AU - Fischer, Jan

AU - Wang, Joseph

AU - Vyskočil, Vlastimil

PY - 2017/3/1

Y1 - 2017/3/1

N2 - This review is focused on genotoxic 2-nitrofluorene, which is a marker for the presence of nitrated polycyclic aromatic hydrocarbons, and summarizes the current knowledge about the negative effects of 2-nitrofluorene and its metabolites on living organisms, especially on their DNA. These findings obtained via in vivo investigations are compared with information obtained using electrochemical DNA biosensors, which represent very promising in vitro alternative to the study of processes proceeding in living organisms during the interaction of their DNA with various xenobiotic compounds.

AB - This review is focused on genotoxic 2-nitrofluorene, which is a marker for the presence of nitrated polycyclic aromatic hydrocarbons, and summarizes the current knowledge about the negative effects of 2-nitrofluorene and its metabolites on living organisms, especially on their DNA. These findings obtained via in vivo investigations are compared with information obtained using electrochemical DNA biosensors, which represent very promising in vitro alternative to the study of processes proceeding in living organisms during the interaction of their DNA with various xenobiotic compounds.

KW - 2-nitrofluorene

KW - Carbon electrodes

KW - DNA adducts

KW - DNA biosensors

KW - DNA damage detection

KW - Mercury electrodes

KW - Nitrated polycyclic aromatic hydrocarbons

UR - http://www.scopus.com/inward/record.url?scp=85016187279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016187279&partnerID=8YFLogxK

M3 - Статья

VL - 111

SP - 178

EP - 185

JO - Chemicke Listy

JF - Chemicke Listy

SN - 0009-2770

IS - 3

ER -