Působení genotoxického 2-nitrofluorenu a jeho metabolitů na DNA in vivo a sledování tohoto působení pomocí elektrochemických DNA biosenzorů in vitro

Translated title of the contribution: Interaction of genotoxic 2-nitrofluorene and its metabolites with DNA in vivo and its monitoring using electrochemical DNA biosensors in vitro

Štěpánka Skalová, Klára Stávková, Andrea Hájková, Jiří Barek, Jan Fischer, Joseph Wang, Vlastimil Vyskočil

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This review is focused on genotoxic 2-nitrofluorene, which is a marker for the presence of nitrated polycyclic aromatic hydrocarbons, and summarizes the current knowledge about the negative effects of 2-nitrofluorene and its metabolites on living organisms, especially on their DNA. These findings obtained via in vivo investigations are compared with information obtained using electrochemical DNA biosensors, which represent very promising in vitro alternative to the study of processes proceeding in living organisms during the interaction of their DNA with various xenobiotic compounds.

Translated title of the contributionInteraction of genotoxic 2-nitrofluorene and its metabolites with DNA in vivo and its monitoring using electrochemical DNA biosensors in vitro
Original languageCzech
Pages (from-to)178-185
Number of pages8
JournalChemicke Listy
Volume111
Issue number3
Publication statusPublished - 1 Mar 2017
Externally publishedYes

Keywords

  • 2-nitrofluorene
  • Carbon electrodes
  • DNA adducts
  • DNA biosensors
  • DNA damage detection
  • Mercury electrodes
  • Nitrated polycyclic aromatic hydrocarbons

ASJC Scopus subject areas

  • Chemistry(all)

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