Interaction of corundum and quartz nanocrystals with erythrocyte membranes

P. V. Mokrushnikov, L. E. Panin, B. N. Zaitsev, N. S. Doronin, A. I. Kozelskaya, A. V. Panin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mechanisms of interaction of quartz and corundum nanocrystals with erythrocyte membranes were studied by means of atomic force microscopy and fluorescence analysis. Hydrophobic, chemically inert nanocrystals larger than a critical size (20-25 nm) can bind to erythrocyte membranes without damaging them. If the size of the nanocrystals is less than 15 nm, they can penetrate into the lipid bilayer membranes. This decreases the membrane microviscosity, and pores appear, which leads to cell lysis. A thermodynamic explication of the critical size of the nanocrystals is given.

Original languageEnglish
Pages (from-to)1074-1077
Number of pages4
JournalBiophysics
Volume56
Issue number6
DOIs
Publication statusPublished - 1 Dec 2011

Keywords

  • atomic force microscopy
  • fluorescence analysis
  • membrane microviscosity
  • nanocrystals
  • plasma membrane

ASJC Scopus subject areas

  • Biophysics

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