Interaction of corundum and quartz nanocrystals with erythrocyte membranes

Abstract

Mechanisms of interaction of quartz and corundum nanocrystals with erythrocyte membranes were studied by means of atomic force microscopy and fluorescence analysis. Hydrophobic, chemically inert nanocrystals larger than a critical size (20-25 nm) can bind to erythrocyte membranes without damaging them. If the size of the nanocrystals is less than 15 nm, they can penetrate into the lipid bilayer membranes. This decreases the membrane microviscosity, and pores appear, which leads to cell lysis. A thermodynamic explication of the critical size of the nanocrystals is given.

Original language	English
Pages (from-to)	1074-1077
Number of pages	4
Journal	Biophysics
Volume	56
Issue number	6
DOIs	https://doi.org/10.1134/S0006350911060133
Publication status	Published - 1 Dec 2011

Keywords

atomic force microscopy
fluorescence analysis
membrane microviscosity
nanocrystals
plasma membrane

ASJC Scopus subject areas

Biophysics

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10.1134/S0006350911060133

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title = "Interaction of corundum and quartz nanocrystals with erythrocyte membranes",

abstract = "Mechanisms of interaction of quartz and corundum nanocrystals with erythrocyte membranes were studied by means of atomic force microscopy and fluorescence analysis. Hydrophobic, chemically inert nanocrystals larger than a critical size (20-25 nm) can bind to erythrocyte membranes without damaging them. If the size of the nanocrystals is less than 15 nm, they can penetrate into the lipid bilayer membranes. This decreases the membrane microviscosity, and pores appear, which leads to cell lysis. A thermodynamic explication of the critical size of the nanocrystals is given.",

keywords = "atomic force microscopy, fluorescence analysis, membrane microviscosity, nanocrystals, plasma membrane",

author = "Mokrushnikov, {P. V.} and Panin, {L. E.} and Zaitsev, {B. N.} and Doronin, {N. S.} and Kozelskaya, {A. I.} and Panin, {A. V.}",

year = "2011",

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day = "1",

doi = "10.1134/S0006350911060133",

language = "English",

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pages = "1074--1077",

journal = "Biophysics (Russian Federation)",

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TY - JOUR

T1 - Interaction of corundum and quartz nanocrystals with erythrocyte membranes

AU - Mokrushnikov, P. V.

AU - Panin, L. E.

AU - Zaitsev, B. N.

AU - Doronin, N. S.

AU - Kozelskaya, A. I.

AU - Panin, A. V.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Mechanisms of interaction of quartz and corundum nanocrystals with erythrocyte membranes were studied by means of atomic force microscopy and fluorescence analysis. Hydrophobic, chemically inert nanocrystals larger than a critical size (20-25 nm) can bind to erythrocyte membranes without damaging them. If the size of the nanocrystals is less than 15 nm, they can penetrate into the lipid bilayer membranes. This decreases the membrane microviscosity, and pores appear, which leads to cell lysis. A thermodynamic explication of the critical size of the nanocrystals is given.

AB - Mechanisms of interaction of quartz and corundum nanocrystals with erythrocyte membranes were studied by means of atomic force microscopy and fluorescence analysis. Hydrophobic, chemically inert nanocrystals larger than a critical size (20-25 nm) can bind to erythrocyte membranes without damaging them. If the size of the nanocrystals is less than 15 nm, they can penetrate into the lipid bilayer membranes. This decreases the membrane microviscosity, and pores appear, which leads to cell lysis. A thermodynamic explication of the critical size of the nanocrystals is given.

KW - atomic force microscopy

KW - fluorescence analysis

KW - membrane microviscosity

KW - nanocrystals

KW - plasma membrane

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JO - Biophysics (Russian Federation)

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