Abstract
Mechanisms of interaction of quartz and corundum nanocrystals with erythrocyte membranes were studied by means of atomic force microscopy and fluorescence analysis. Hydrophobic, chemically inert nanocrystals larger than a critical size (20-25 nm) can bind to erythrocyte membranes without damaging them. If the size of the nanocrystals is less than 15 nm, they can penetrate into the lipid bilayer membranes. This decreases the membrane microviscosity, and pores appear, which leads to cell lysis. A thermodynamic explication of the critical size of the nanocrystals is given.
| Original language | English |
|---|---|
| Pages (from-to) | 1074-1077 |
| Number of pages | 4 |
| Journal | Biophysics |
| Volume | 56 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Dec 2011 |
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Keywords
- atomic force microscopy
- fluorescence analysis
- membrane microviscosity
- nanocrystals
- plasma membrane
ASJC Scopus subject areas
- Biophysics
Cite this
Interaction of corundum and quartz nanocrystals with erythrocyte membranes. / Mokrushnikov, P. V.; Panin, L. E.; Zaitsev, B. N.; Doronin, N. S.; Kozelskaya, A. I.; Panin, A. V.
In: Biophysics, Vol. 56, No. 6, 01.12.2011, p. 1074-1077.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interaction of corundum and quartz nanocrystals with erythrocyte membranes
AU - Mokrushnikov, P. V.
AU - Panin, L. E.
AU - Zaitsev, B. N.
AU - Doronin, N. S.
AU - Kozelskaya, A. I.
AU - Panin, A. V.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Mechanisms of interaction of quartz and corundum nanocrystals with erythrocyte membranes were studied by means of atomic force microscopy and fluorescence analysis. Hydrophobic, chemically inert nanocrystals larger than a critical size (20-25 nm) can bind to erythrocyte membranes without damaging them. If the size of the nanocrystals is less than 15 nm, they can penetrate into the lipid bilayer membranes. This decreases the membrane microviscosity, and pores appear, which leads to cell lysis. A thermodynamic explication of the critical size of the nanocrystals is given.
AB - Mechanisms of interaction of quartz and corundum nanocrystals with erythrocyte membranes were studied by means of atomic force microscopy and fluorescence analysis. Hydrophobic, chemically inert nanocrystals larger than a critical size (20-25 nm) can bind to erythrocyte membranes without damaging them. If the size of the nanocrystals is less than 15 nm, they can penetrate into the lipid bilayer membranes. This decreases the membrane microviscosity, and pores appear, which leads to cell lysis. A thermodynamic explication of the critical size of the nanocrystals is given.
KW - atomic force microscopy
KW - fluorescence analysis
KW - membrane microviscosity
KW - nanocrystals
KW - plasma membrane
UR - http://www.scopus.com/inward/record.url?scp=84857537753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857537753&partnerID=8YFLogxK
U2 - 10.1134/S0006350911060133
DO - 10.1134/S0006350911060133
M3 - Article
AN - SCOPUS:84857537753
VL - 56
SP - 1074
EP - 1077
JO - Biophysics (Russian Federation)
JF - Biophysics (Russian Federation)
SN - 0006-3509
IS - 6
ER -