INTERACTION EPITHELIUM AND SMOOTH MUSCLE IN THE WALLS OF THE AIRWAYS IN THE NORMAL CONDITIONS AND WHEN FORMING OF HYPERREACTIVITY

Abstract

In the present study was to investigate the effect epithelium on the tone smooth muscle of the airways of guinea pigs under physiological conditions and when forming of experimental asthma. It was found that the amplitude of contractile responses decreased by histaminergic, and serotonergic effects in the presence of epithelium in the control group. Influence epithelium dilatation adrenergic reactions depended on the type of pretreatment factors. The amplitude of the relaxation was reduced in the case of pre-treatment with a solution of potassium, the amount of dilation increased by pretreatment with histamine. The impact of epithelium on contractile responses of smooth muscles disappeared when forming of hyperreactivity.

Original language	English
Pages (from-to)	1206-1215
Number of pages	10
Journal	Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
Volume	102
Issue number	10
Publication status	Published - 1 Oct 2016

ASJC Scopus subject areas

Medicine(all)

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INTERACTION EPITHELIUM AND SMOOTH MUSCLE IN THE WALLS OF THE AIRWAYS IN THE NORMAL CONDITIONS AND WHEN FORMING OF HYPERREACTIVITY. / Dyakova, E. Yu; Davlet'yarova, K. V.; Kapilevich, L. V.; Nosarev, A. V.

In: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, Vol. 102, No. 10, 01.10.2016, p. 1206-1215.

Research output: Contribution to journal › Article › peer-review

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abstract = "In the present study was to investigate the effect epithelium on the tone smooth muscle of the airways of guinea pigs under physiological conditions and when forming of experimental asthma. It was found that the amplitude of contractile responses decreased by histaminergic, and serotonergic effects in the presence of epithelium in the control group. Influence epithelium dilatation adrenergic reactions depended on the type of pretreatment factors. The amplitude of the relaxation was reduced in the case of pre-treatment with a solution of potassium, the amount of dilation increased by pretreatment with histamine. The impact of epithelium on contractile responses of smooth muscles disappeared when forming of hyperreactivity.",

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AU - Kapilevich, L. V.

AU - Nosarev, A. V.

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INTERACTION EPITHELIUM AND SMOOTH MUSCLE IN THE WALLS OF THE AIRWAYS IN THE NORMAL CONDITIONS AND WHEN FORMING OF HYPERREACTIVITY

Abstract

ASJC Scopus subject areas

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