Abstract
The effects of global ischemia (45 min) and reperfusion (30 min) on left-ventricular developed pressure (LVDP), HR, and end-diastolic pressure were studied on isolated perfused rat heart. The following postconditioning protocols were used: 1) 3 cycles of reperfusion (10 sec) and ischemia (10 sec), total cycle duration 20 sec; 2) 6 cycles reperfusion of reperfusion (10 sec) and ischemia (10 sec), total cycle duration 20 sec; 3) 3 cycles of reperfusion (20 sec) and ischemia (20 sec), total cycle duration 40 sec; 4) 6 cycles of reperfusion (20 sec) and ischemia (20 sec), total cycle duration 40 sec; 5) 3 cycles of reperfusion (30 sec) and ischemia (30 sec), total cycle duration 60 sec. The use of several cycles of a total duration of 20 sec had no effect on LVDP, but reduced EDP throughout the reperfusion period. Postconditioning protocol consisting of three 40-sec cycles promoted LVDP recovery during the reperfusion, but had no effect on EDP and decelerated HP normalization. Six 40-sec cycles had no effect on LVDP and EDP, but impeded HR recovery during the reperfusion period. Postconditioning protocol consisting of three 60-sec cycles promoted LVDP increase during the reperfusion and reduced contracture, but these transient effects were accompanied by decelerated HP normalization.
| Original language | English |
|---|---|
| Pages (from-to) | 688-691 |
| Number of pages | 4 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 152 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Apr 2012 |
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Keywords
- Heart
- Ischemia
- Postconditioning
- Reperfusion
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Inotropic and chronotropic effects of ischemic postconditioning on the model of isolated heart. / Maslov, L. N.; Gorbunov, A. S.; Lasukova, T. V.; Lishmanov, Yu B.
In: Bulletin of Experimental Biology and Medicine, Vol. 152, No. 6, 04.2012, p. 688-691.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inotropic and chronotropic effects of ischemic postconditioning on the model of isolated heart
AU - Maslov, L. N.
AU - Gorbunov, A. S.
AU - Lasukova, T. V.
AU - Lishmanov, Yu B.
PY - 2012/4
Y1 - 2012/4
N2 - The effects of global ischemia (45 min) and reperfusion (30 min) on left-ventricular developed pressure (LVDP), HR, and end-diastolic pressure were studied on isolated perfused rat heart. The following postconditioning protocols were used: 1) 3 cycles of reperfusion (10 sec) and ischemia (10 sec), total cycle duration 20 sec; 2) 6 cycles reperfusion of reperfusion (10 sec) and ischemia (10 sec), total cycle duration 20 sec; 3) 3 cycles of reperfusion (20 sec) and ischemia (20 sec), total cycle duration 40 sec; 4) 6 cycles of reperfusion (20 sec) and ischemia (20 sec), total cycle duration 40 sec; 5) 3 cycles of reperfusion (30 sec) and ischemia (30 sec), total cycle duration 60 sec. The use of several cycles of a total duration of 20 sec had no effect on LVDP, but reduced EDP throughout the reperfusion period. Postconditioning protocol consisting of three 40-sec cycles promoted LVDP recovery during the reperfusion, but had no effect on EDP and decelerated HP normalization. Six 40-sec cycles had no effect on LVDP and EDP, but impeded HR recovery during the reperfusion period. Postconditioning protocol consisting of three 60-sec cycles promoted LVDP increase during the reperfusion and reduced contracture, but these transient effects were accompanied by decelerated HP normalization.
AB - The effects of global ischemia (45 min) and reperfusion (30 min) on left-ventricular developed pressure (LVDP), HR, and end-diastolic pressure were studied on isolated perfused rat heart. The following postconditioning protocols were used: 1) 3 cycles of reperfusion (10 sec) and ischemia (10 sec), total cycle duration 20 sec; 2) 6 cycles reperfusion of reperfusion (10 sec) and ischemia (10 sec), total cycle duration 20 sec; 3) 3 cycles of reperfusion (20 sec) and ischemia (20 sec), total cycle duration 40 sec; 4) 6 cycles of reperfusion (20 sec) and ischemia (20 sec), total cycle duration 40 sec; 5) 3 cycles of reperfusion (30 sec) and ischemia (30 sec), total cycle duration 60 sec. The use of several cycles of a total duration of 20 sec had no effect on LVDP, but reduced EDP throughout the reperfusion period. Postconditioning protocol consisting of three 40-sec cycles promoted LVDP recovery during the reperfusion, but had no effect on EDP and decelerated HP normalization. Six 40-sec cycles had no effect on LVDP and EDP, but impeded HR recovery during the reperfusion period. Postconditioning protocol consisting of three 60-sec cycles promoted LVDP increase during the reperfusion and reduced contracture, but these transient effects were accompanied by decelerated HP normalization.
KW - Heart
KW - Ischemia
KW - Postconditioning
KW - Reperfusion
UR - http://www.scopus.com/inward/record.url?scp=84862732945&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862732945&partnerID=8YFLogxK
U2 - 10.1007/s10517-012-1607-x
DO - 10.1007/s10517-012-1607-x
M3 - Article
VL - 152
SP - 688
EP - 691
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 6
ER -