Abstract
Objective:Inhaled nitric oxide (iNO) is a potential new therapy for prevention of bronchopulmonary dysplasia and brain injury in premature infants. This study examined dose-related effects of iNO on NO metabolites as evidence of NO delivery.Study Design:A subset of 102 premature infants in the NO CLD trial, receiving 24 days of iNO (20 p.p.m. decreasing to 2 p.p.m.) or placebo, were analyzed. Tracheal aspirate (TA) and plasma samples collected at enrollment and at intervals during study gas were analyzed for NO metabolites.Result:iNO treatment increased NO metabolites in TA at 20 and 10 p.p.m. (1.7- to 2.3-fold vs control) and in plasma at 20, 10, and 5 p.p.m. (1.6- to 2.3-fold). In post hoc analysis, treated infants with lower metabolite levels at entry had an improved clinical outcome.Conclusion:iNO causes dose-related increases in NO metabolites in the circulation as well as lung fluid, as evidenced by TA analysis, showing NO delivery to these compartments.
| Original language | English |
|---|---|
| Pages (from-to) | 275-280 |
| Number of pages | 6 |
| Journal | Journal of Perinatology |
| Volume | 30 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2010 |
| Externally published | Yes |
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Keywords
- Bronchopulmonary dysplasia
- Nitrite
- NO CLD trial
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Pediatrics, Perinatology, and Child Health
Cite this
Inhaled nitric oxide in premature infants : Effect on tracheal aspirate and plasma nitric oxide metabolites. / Posencheg, M. A.; Gow, A. J.; Truog, W. E.; Ballard, R. A.; Cnaan, A.; Golombek, S. G.; Ballard, P. L.
In: Journal of Perinatology, Vol. 30, No. 4, 04.2010, p. 275-280.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhaled nitric oxide in premature infants
T2 - Effect on tracheal aspirate and plasma nitric oxide metabolites
AU - Posencheg, M. A.
AU - Gow, A. J.
AU - Truog, W. E.
AU - Ballard, R. A.
AU - Cnaan, A.
AU - Golombek, S. G.
AU - Ballard, P. L.
PY - 2010/4
Y1 - 2010/4
N2 - Objective:Inhaled nitric oxide (iNO) is a potential new therapy for prevention of bronchopulmonary dysplasia and brain injury in premature infants. This study examined dose-related effects of iNO on NO metabolites as evidence of NO delivery.Study Design:A subset of 102 premature infants in the NO CLD trial, receiving 24 days of iNO (20 p.p.m. decreasing to 2 p.p.m.) or placebo, were analyzed. Tracheal aspirate (TA) and plasma samples collected at enrollment and at intervals during study gas were analyzed for NO metabolites.Result:iNO treatment increased NO metabolites in TA at 20 and 10 p.p.m. (1.7- to 2.3-fold vs control) and in plasma at 20, 10, and 5 p.p.m. (1.6- to 2.3-fold). In post hoc analysis, treated infants with lower metabolite levels at entry had an improved clinical outcome.Conclusion:iNO causes dose-related increases in NO metabolites in the circulation as well as lung fluid, as evidenced by TA analysis, showing NO delivery to these compartments.
AB - Objective:Inhaled nitric oxide (iNO) is a potential new therapy for prevention of bronchopulmonary dysplasia and brain injury in premature infants. This study examined dose-related effects of iNO on NO metabolites as evidence of NO delivery.Study Design:A subset of 102 premature infants in the NO CLD trial, receiving 24 days of iNO (20 p.p.m. decreasing to 2 p.p.m.) or placebo, were analyzed. Tracheal aspirate (TA) and plasma samples collected at enrollment and at intervals during study gas were analyzed for NO metabolites.Result:iNO treatment increased NO metabolites in TA at 20 and 10 p.p.m. (1.7- to 2.3-fold vs control) and in plasma at 20, 10, and 5 p.p.m. (1.6- to 2.3-fold). In post hoc analysis, treated infants with lower metabolite levels at entry had an improved clinical outcome.Conclusion:iNO causes dose-related increases in NO metabolites in the circulation as well as lung fluid, as evidenced by TA analysis, showing NO delivery to these compartments.
KW - Bronchopulmonary dysplasia
KW - Nitrite
KW - NO CLD trial
UR - http://www.scopus.com/inward/record.url?scp=77950517036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950517036&partnerID=8YFLogxK
U2 - 10.1038/jp.2009.155
DO - 10.1038/jp.2009.155
M3 - Article
C2 - 19812581
AN - SCOPUS:77950517036
VL - 30
SP - 275
EP - 280
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
IS - 4
ER -