Inhaled nitric oxide in premature infants: Effect on tracheal aspirate and plasma nitric oxide metabolites

M. A. Posencheg, A. J. Gow, W. E. Truog, R. A. Ballard, A. Cnaan, S. G. Golombek, P. L. Ballard

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13 Citations (Scopus)

Abstract

Objective:Inhaled nitric oxide (iNO) is a potential new therapy for prevention of bronchopulmonary dysplasia and brain injury in premature infants. This study examined dose-related effects of iNO on NO metabolites as evidence of NO delivery.Study Design:A subset of 102 premature infants in the NO CLD trial, receiving 24 days of iNO (20 p.p.m. decreasing to 2 p.p.m.) or placebo, were analyzed. Tracheal aspirate (TA) and plasma samples collected at enrollment and at intervals during study gas were analyzed for NO metabolites.Result:iNO treatment increased NO metabolites in TA at 20 and 10 p.p.m. (1.7- to 2.3-fold vs control) and in plasma at 20, 10, and 5 p.p.m. (1.6- to 2.3-fold). In post hoc analysis, treated infants with lower metabolite levels at entry had an improved clinical outcome.Conclusion:iNO causes dose-related increases in NO metabolites in the circulation as well as lung fluid, as evidenced by TA analysis, showing NO delivery to these compartments.

Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalJournal of Perinatology
Volume30
Issue number4
DOIs
Publication statusPublished - Apr 2010
Externally publishedYes

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Keywords

  • Bronchopulmonary dysplasia
  • Nitrite
  • NO CLD trial

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Posencheg, M. A., Gow, A. J., Truog, W. E., Ballard, R. A., Cnaan, A., Golombek, S. G., & Ballard, P. L. (2010). Inhaled nitric oxide in premature infants: Effect on tracheal aspirate and plasma nitric oxide metabolites. Journal of Perinatology, 30(4), 275-280. https://doi.org/10.1038/jp.2009.155