Abstract
Objective:Inhaled nitric oxide (iNO) is a potential new therapy for prevention of bronchopulmonary dysplasia and brain injury in premature infants. This study examined dose-related effects of iNO on NO metabolites as evidence of NO delivery.Study Design:A subset of 102 premature infants in the NO CLD trial, receiving 24 days of iNO (20 p.p.m. decreasing to 2 p.p.m.) or placebo, were analyzed. Tracheal aspirate (TA) and plasma samples collected at enrollment and at intervals during study gas were analyzed for NO metabolites.Result:iNO treatment increased NO metabolites in TA at 20 and 10 p.p.m. (1.7- to 2.3-fold vs control) and in plasma at 20, 10, and 5 p.p.m. (1.6- to 2.3-fold). In post hoc analysis, treated infants with lower metabolite levels at entry had an improved clinical outcome.Conclusion:iNO causes dose-related increases in NO metabolites in the circulation as well as lung fluid, as evidenced by TA analysis, showing NO delivery to these compartments.
Original language | English |
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Pages (from-to) | 275-280 |
Number of pages | 6 |
Journal | Journal of Perinatology |
Volume | 30 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2010 |
Externally published | Yes |
Keywords
- Bronchopulmonary dysplasia
- Nitrite
- NO CLD trial
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Pediatrics, Perinatology, and Child Health