Influence of the Structure of the Titanium Oxide Coating Surface on Immunocompetent Tumor Cells

Abstract

Results of a study of the properties of titanium oxide based coatings deposited on titanium substrates by microarc oxidation are presented that establish a relationship between physical and mechanical properties of the coating surface and their medical and biological properties. The required surface topography is formed by sandblasting of the substrate and is controlled by values of the roughness index Ra. A linear dependence of the amplitude of negative electrostatic potential of the oxide coating on the Ra value is established. The topography of the micro-arc coating surface determines its negative surface potential that apparently reduces the viability of the leukemia Т cells of the Jurkat line via electrostatic and biological mechanisms unrelated to the generation of intracellular reactive oxygen species.

Original language	English
Pages (from-to)	1527-1533
Number of pages	7
Journal	Russian Physics Journal
Volume	58
Issue number	11
DOIs	https://doi.org/10.1007/s11182-016-0678-y
Publication status	Published - 1 Mar 2016

Keywords

in vitro
Jurkat Т cells
oxide coatings
roughness
surface potential
titanium nanoparticles
titanium substrates

ASJC Scopus subject areas

Physics and Astronomy(all)

Access to Document

10.1007/s11182-016-0678-y

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Khlusov, IA., Sharkeev, Y. P., Pichugin, V. F., Legostaeva, E. V., Litvinova, L. S., Shupletsova, V. V., Sokhonevich, N. A., Khaziakhmatova, O. G., Khlusova, M. Y., Gutor, S. S., & Tolkacheva, T. V. (2016). Influence of the Structure of the Titanium Oxide Coating Surface on Immunocompetent Tumor Cells. Russian Physics Journal, 58(11), 1527-1533. https://doi.org/10.1007/s11182-016-0678-y

Influence of the Structure of the Titanium Oxide Coating Surface on Immunocompetent Tumor Cells. / Khlusov, Igor Albertovich ; Sharkeev, Y. P.; Pichugin, V. F.; Legostaeva, E. V.; Litvinova, L. S.; Shupletsova, V. V.; Sokhonevich, N. A.; Khaziakhmatova, O. G.; Khlusova, M. Y.; Gutor, S. S.; Tolkacheva, T. V.

In: Russian Physics Journal, Vol. 58, No. 11, 01.03.2016, p. 1527-1533.

Research output: Contribution to journal › Article

Khlusov, IA , Sharkeev, YP , Pichugin, VF, Legostaeva, EV, Litvinova, LS, Shupletsova, VV, Sokhonevich, NA, Khaziakhmatova, OG, Khlusova, MY, Gutor, SS & Tolkacheva, TV 2016, 'Influence of the Structure of the Titanium Oxide Coating Surface on Immunocompetent Tumor Cells', Russian Physics Journal, vol. 58, no. 11, pp. 1527-1533. https://doi.org/10.1007/s11182-016-0678-y

Khlusov, Igor Albertovich ; Sharkeev, Y. P. ; Pichugin, V. F. ; Legostaeva, E. V. ; Litvinova, L. S. ; Shupletsova, V. V. ; Sokhonevich, N. A. ; Khaziakhmatova, O. G. ; Khlusova, M. Y. ; Gutor, S. S. ; Tolkacheva, T. V. / Influence of the Structure of the Titanium Oxide Coating Surface on Immunocompetent Tumor Cells. In: Russian Physics Journal. 2016 ; Vol. 58, No. 11. pp. 1527-1533.

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title = "Influence of the Structure of the Titanium Oxide Coating Surface on Immunocompetent Tumor Cells",

abstract = "Results of a study of the properties of titanium oxide based coatings deposited on titanium substrates by microarc oxidation are presented that establish a relationship between physical and mechanical properties of the coating surface and their medical and biological properties. The required surface topography is formed by sandblasting of the substrate and is controlled by values of the roughness index Ra. A linear dependence of the amplitude of negative electrostatic potential of the oxide coating on the Ra value is established. The topography of the micro-arc coating surface determines its negative surface potential that apparently reduces the viability of the leukemia Т cells of the Jurkat line via electrostatic and biological mechanisms unrelated to the generation of intracellular reactive oxygen species.",

keywords = "in vitro, Jurkat Т cells, oxide coatings, roughness, surface potential, titanium nanoparticles, titanium substrates",

author = "Igor Albertovich Khlusov and Sharkeev, {Y. P.} and Pichugin, {V. F.} and Legostaeva, {E. V.} and Litvinova, {L. S.} and Shupletsova, {V. V.} and Sokhonevich, {N. A.} and Khaziakhmatova, {O. G.} and Khlusova, {M. Y.} and Gutor, {S. S.} and Tolkacheva, {T. V.}",

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AU - Khlusov, Igor Albertovich

AU - Sharkeev, Y. P.

AU - Pichugin, V. F.

AU - Legostaeva, E. V.

AU - Litvinova, L. S.

AU - Shupletsova, V. V.

AU - Sokhonevich, N. A.

AU - Khaziakhmatova, O. G.

AU - Khlusova, M. Y.

AU - Gutor, S. S.

AU - Tolkacheva, T. V.

PY - 2016/3/1

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N2 - Results of a study of the properties of titanium oxide based coatings deposited on titanium substrates by microarc oxidation are presented that establish a relationship between physical and mechanical properties of the coating surface and their medical and biological properties. The required surface topography is formed by sandblasting of the substrate and is controlled by values of the roughness index Ra. A linear dependence of the amplitude of negative electrostatic potential of the oxide coating on the Ra value is established. The topography of the micro-arc coating surface determines its negative surface potential that apparently reduces the viability of the leukemia Т cells of the Jurkat line via electrostatic and biological mechanisms unrelated to the generation of intracellular reactive oxygen species.

AB - Results of a study of the properties of titanium oxide based coatings deposited on titanium substrates by microarc oxidation are presented that establish a relationship between physical and mechanical properties of the coating surface and their medical and biological properties. The required surface topography is formed by sandblasting of the substrate and is controlled by values of the roughness index Ra. A linear dependence of the amplitude of negative electrostatic potential of the oxide coating on the Ra value is established. The topography of the micro-arc coating surface determines its negative surface potential that apparently reduces the viability of the leukemia Т cells of the Jurkat line via electrostatic and biological mechanisms unrelated to the generation of intracellular reactive oxygen species.

KW - in vitro

KW - Jurkat Т cells

KW - oxide coatings

KW - roughness

KW - surface potential

KW - titanium nanoparticles

KW - titanium substrates

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