In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Elina A. Genina, Yulia I. Svenskaya, Irina Yu Yanina, Leonid E. Dolotov, Nikita A. Navolokin, Alexey N. Bashkatov, Georgy S. Terentyuk, Alla B. Bucharskaya, Galina N. Maslyakova, Dmitry A. Gorin, Valery V. Tuchin, Gleb B. Sukhorukov

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 µm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.

Original languageEnglish
Pages (from-to)2082-2087
Number of pages6
JournalBiomedical Optics Express
Issue number6
Publication statusPublished - 1 Jun 2016
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

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