In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Elina A. Genina, Yulia I. Svenskaya, Irina Yu Yanina, Leonid E. Dolotov, Nikita A. Navolokin, Alexey N. Bashkatov, Georgy S. Terentyuk, Alla B. Bucharskaya, Galina N. Maslyakova, Dmitry A. Gorin, Valery V. Tuchin, Gleb B. Sukhorukov

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 µm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.

Original languageEnglish
Pages (from-to)2082-2087
Number of pages6
JournalBiomedical Optics Express
Volume7
Issue number6
DOIs
Publication statusPublished - 1 Jun 2016
Externally publishedYes

Fingerprint

Calcium Carbonate
calcium carbonates
Dermis
Nanoparticles
delivery
Lasers
Solid-State Lasers
Optical Coherence Tomography
nanoparticles
Skin
rats
lasers
YAG lasers
pulsed lasers
dissolving
tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Genina, E. A., Svenskaya, Y. I., Yanina, I. Y., Dolotov, L. E., Navolokin, N. A., Bashkatov, A. N., ... Sukhorukov, G. B. (2016). In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers. Biomedical Optics Express, 7(6), 2082-2087. https://doi.org/10.1364/BOE.7.002082

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers. / Genina, Elina A.; Svenskaya, Yulia I.; Yanina, Irina Yu; Dolotov, Leonid E.; Navolokin, Nikita A.; Bashkatov, Alexey N.; Terentyuk, Georgy S.; Bucharskaya, Alla B.; Maslyakova, Galina N.; Gorin, Dmitry A.; Tuchin, Valery V.; Sukhorukov, Gleb B.

In: Biomedical Optics Express, Vol. 7, No. 6, 01.06.2016, p. 2082-2087.

Research output: Contribution to journalArticle

Genina, EA, Svenskaya, YI, Yanina, IY, Dolotov, LE, Navolokin, NA, Bashkatov, AN, Terentyuk, GS, Bucharskaya, AB, Maslyakova, GN, Gorin, DA, Tuchin, VV & Sukhorukov, GB 2016, 'In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers', Biomedical Optics Express, vol. 7, no. 6, pp. 2082-2087. https://doi.org/10.1364/BOE.7.002082
Genina EA, Svenskaya YI, Yanina IY, Dolotov LE, Navolokin NA, Bashkatov AN et al. In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers. Biomedical Optics Express. 2016 Jun 1;7(6):2082-2087. https://doi.org/10.1364/BOE.7.002082
Genina, Elina A. ; Svenskaya, Yulia I. ; Yanina, Irina Yu ; Dolotov, Leonid E. ; Navolokin, Nikita A. ; Bashkatov, Alexey N. ; Terentyuk, Georgy S. ; Bucharskaya, Alla B. ; Maslyakova, Galina N. ; Gorin, Dmitry A. ; Tuchin, Valery V. ; Sukhorukov, Gleb B. / In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers. In: Biomedical Optics Express. 2016 ; Vol. 7, No. 6. pp. 2082-2087.
@article{011c0359590d479db77c98fe4a05a812,
title = "In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers",
abstract = "We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 µm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.",
author = "Genina, {Elina A.} and Svenskaya, {Yulia I.} and Yanina, {Irina Yu} and Dolotov, {Leonid E.} and Navolokin, {Nikita A.} and Bashkatov, {Alexey N.} and Terentyuk, {Georgy S.} and Bucharskaya, {Alla B.} and Maslyakova, {Galina N.} and Gorin, {Dmitry A.} and Tuchin, {Valery V.} and Sukhorukov, {Gleb B.}",
year = "2016",
month = "6",
day = "1",
doi = "10.1364/BOE.7.002082",
language = "English",
volume = "7",
pages = "2082--2087",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "6",

}

TY - JOUR

T1 - In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

AU - Genina, Elina A.

AU - Svenskaya, Yulia I.

AU - Yanina, Irina Yu

AU - Dolotov, Leonid E.

AU - Navolokin, Nikita A.

AU - Bashkatov, Alexey N.

AU - Terentyuk, Georgy S.

AU - Bucharskaya, Alla B.

AU - Maslyakova, Galina N.

AU - Gorin, Dmitry A.

AU - Tuchin, Valery V.

AU - Sukhorukov, Gleb B.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 µm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.

AB - We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 µm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.

UR - http://www.scopus.com/inward/record.url?scp=84971372798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971372798&partnerID=8YFLogxK

U2 - 10.1364/BOE.7.002082

DO - 10.1364/BOE.7.002082

M3 - Article

VL - 7

SP - 2082

EP - 2087

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 6

ER -