In vitro evaluation of Ag doped hydroxyapatite coatings in acellular media

Diana M. Vranceanu, Anca C. Parau, Cosmin M. Cotrut, Adrian E. Kiss, Lidia R. Constantin, Viorel Braic, Alina Vladescu

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


© 2019 Elsevier Ltd and Techna Group S.r.l. The goal of the present contribution is to show what is the effect of Ag addition on in vitro bioactivity and degradation characteristics of hydroxyapatite (HAP) in simulated body fluid (SBF), Dulbecco's Modified Eagle's medium (DMEM) and phosphate buffer solution (PBS) over a period of immersion at 37 ± 0.5 °C ranged from 1 to 21 days. Also, the corrosion investigations in all three media were carried out at 37 ± 0.5 °C. The results showed that the coatings behaviour is modulated with respect to the testing media and indicated that the Ag addition into hydroxyapatite has enhanced the general behaviour of HAP by either preventing and/or reducing dissolution of the HAP in SBF and DMEM solutions, while in PBS media the Ag addition contributed to a very slow degradation of hydroxyapatite. Thus, it can be said that the Ag addition into HAP enhances the overall chemical stability and behaviour in acellular media.
Original languageEnglish
Pages (from-to)11050-11061
Number of pages12
JournalCeramics International
Issue number8
Publication statusPublished - 1 Jun 2019


  • Apatite
  • Biomedical applications
  • Corrosion
  • Electron microscopy
  • Films
  • Interfaces
  • X-ray method

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