In vitro biocompatibility of human endothelial cells with collagen-doxycycline matrices

I. Titorencu, M. G. Albu, M. Giurginca, V. Jinga, I. Antoniac, V. Trandafir, C. Cotrut, F. Miculescu, M. Simionescu

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The aim of this study was to test the biocompatibility between collagen-doxycycline matrices with various porosities and human endothelial cells. Collagen matrices were prepared by freeze-drying process. The crosslinking degree of collagen matrices was evaluated by FT-IR spectroscopy, the matrices morphology by SEM microscopy. The biocompatibility of collagen matrices with endothelial cells was monitored byfluorescence and transmission electron microscopy. We found that the three-dimensional structures of matrix with 1.2% collagen, 0.2% doxycycline crosslinked with 0.25% glutaraldehyde was optimal in terms of biodegradability, morphology and endothelial cells biocompatibility indicating the use of these scaffolds in tissueengineering.

Original languageEnglish
Pages (from-to)82-96
Number of pages15
JournalMolecular Crystals and Liquid Crystals
Publication statusPublished - 1 Jan 2010
Externally publishedYes


  • Biocompatibility
  • Collagen-doxycycline matrices
  • Endothelial cells

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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