In vitro biocompatibility of human endothelial cells with collagen-doxycycline matrices

I. Titorencu, M. G. Albu, M. Giurginca, V. Jinga, I. Antoniac, V. Trandafir, C. Cotrut, F. Miculescu, M. Simionescu

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The aim of this study was to test the biocompatibility between collagen-doxycycline matrices with various porosities and human endothelial cells. Collagen matrices were prepared by freeze-drying process. The crosslinking degree of collagen matrices was evaluated by FT-IR spectroscopy, the matrices morphology by SEM microscopy. The biocompatibility of collagen matrices with endothelial cells was monitored byfluorescence and transmission electron microscopy. We found that the three-dimensional structures of matrix with 1.2% collagen, 0.2% doxycycline crosslinked with 0.25% glutaraldehyde was optimal in terms of biodegradability, morphology and endothelial cells biocompatibility indicating the use of these scaffolds in tissueengineering.

Original languageEnglish
Pages (from-to)82-96
Number of pages15
JournalMolecular Crystals and Liquid Crystals
Publication statusPublished - 1 Jan 2010
Externally publishedYes



  • Biocompatibility
  • Collagen-doxycycline matrices
  • Endothelial cells

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Titorencu, I., Albu, M. G., Giurginca, M., Jinga, V., Antoniac, I., Trandafir, V., ... Simionescu, M. (2010). In vitro biocompatibility of human endothelial cells with collagen-doxycycline matrices. Molecular Crystals and Liquid Crystals, 523, 82-96.