In vitro assessment of hydroxyapatite coating on the surface of additive manufactured ti6al4v scaffolds

Ekaterina Chudinova, Maria Surmeneva, Andrey Koptioug, Irina Savintseva, Irina Selezneva, Per Skoglund, M. Syrtanov, Roman Surmenev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Custom orthopedic and dental implants may be fabricated by additive manufacturing (AM), for example using electron beam melting technology. This study is focused on the modification of the surface of Ti6Al4V alloy coin-like scaffolds fabricated via AM technology (EBM®) by radio frequency (RF) magnetron sputter deposition of hydroxyapatite (HA) coating. The scaffolds with HA coating were characterized by Scanning Electron microscopy, X-ray diffraction. HA coating showed a nanocrystalline structure with the crystallites of an average size of 32±9 nm. The ability of the surface to support adhesion and the proliferation of human mesenchymal stem cells was studied using biological short-term tests in vitro. In according to in vitro assessment, thin HA coating stimulated the attachment and proliferation of cells. Human mesenchymal stem cells cultured on the HA-coated scaffold also formed mineralized nodules.

Original languageEnglish
Title of host publicationTHERMEC 2016
PublisherTrans Tech Publications Ltd
Pages2444-2449
Number of pages6
Volume879
ISBN (Print)9783035711295
DOIs
Publication statusPublished - 2017
Event9th International Conference on Processing and Manufacturing of Advanced Materials, THERMEC 2016 - Graz, Austria
Duration: 29 May 20163 Jun 2016

Publication series

NameMaterials Science Forum
Volume879
ISSN (Print)0255-5476

Conference

Conference9th International Conference on Processing and Manufacturing of Advanced Materials, THERMEC 2016
CountryAustria
CityGraz
Period29.5.163.6.16

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Keywords

  • Additive manufacturing
  • Electron beam melting
  • Hydroxyapatite
  • Radio frequency (RF) magnetron sputtering

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Chudinova, E., Surmeneva, M., Koptioug, A., Savintseva, I., Selezneva, I., Skoglund, P., Syrtanov, M., & Surmenev, R. (2017). In vitro assessment of hydroxyapatite coating on the surface of additive manufactured ti6al4v scaffolds. In THERMEC 2016 (Vol. 879, pp. 2444-2449). (Materials Science Forum; Vol. 879). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/MSF.879.2444