Abstract
Custom orthopedic and dental implants may be fabricated by additive manufacturing (AM), for example using electron beam melting technology. This study is focused on the modification of the surface of Ti6Al4V alloy coin-like scaffolds fabricated via AM technology (EBM®) by radio frequency (RF) magnetron sputter deposition of hydroxyapatite (HA) coating. The scaffolds with HA coating were characterized by Scanning Electron microscopy, X-ray diffraction. HA coating showed a nanocrystalline structure with the crystallites of an average size of 32±9 nm. The ability of the surface to support adhesion and the proliferation of human mesenchymal stem cells was studied using biological short-term tests in vitro. In according to in vitro assessment, thin HA coating stimulated the attachment and proliferation of cells. Human mesenchymal stem cells cultured on the HA-coated scaffold also formed mineralized nodules.
| Original language | English |
|---|---|
| Title of host publication | THERMEC 2016 |
| Publisher | Trans Tech Publications Ltd |
| Pages | 2444-2449 |
| Number of pages | 6 |
| Volume | 879 |
| ISBN (Print) | 9783035711295 |
| DOIs | |
| Publication status | Published - 2017 |
| Event | 9th International Conference on Processing and Manufacturing of Advanced Materials, THERMEC 2016 - Graz, Austria Duration: 29 May 2016 → 3 Jun 2016 |
Publication series
| Name | Materials Science Forum |
|---|---|
| Volume | 879 |
| ISSN (Print) | 0255-5476 |
Conference
| Conference | 9th International Conference on Processing and Manufacturing of Advanced Materials, THERMEC 2016 |
|---|---|
| Country | Austria |
| City | Graz |
| Period | 29.5.16 → 3.6.16 |
Fingerprint
Keywords
- Additive manufacturing
- Electron beam melting
- Hydroxyapatite
- Radio frequency (RF) magnetron sputtering
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering
Cite this
In vitro assessment of hydroxyapatite coating on the surface of additive manufactured ti6al4v scaffolds. / Chudinova, Ekaterina; Surmeneva, Maria; Koptioug, Andrey; Savintseva, Irina; Selezneva, Irina; Skoglund, Per; Syrtanov, M.; Surmenev, Roman.
THERMEC 2016. Vol. 879 Trans Tech Publications Ltd, 2017. p. 2444-2449 (Materials Science Forum; Vol. 879).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - In vitro assessment of hydroxyapatite coating on the surface of additive manufactured ti6al4v scaffolds
AU - Chudinova, Ekaterina
AU - Surmeneva, Maria
AU - Koptioug, Andrey
AU - Savintseva, Irina
AU - Selezneva, Irina
AU - Skoglund, Per
AU - Syrtanov, M.
AU - Surmenev, Roman
PY - 2017
Y1 - 2017
N2 - Custom orthopedic and dental implants may be fabricated by additive manufacturing (AM), for example using electron beam melting technology. This study is focused on the modification of the surface of Ti6Al4V alloy coin-like scaffolds fabricated via AM technology (EBM®) by radio frequency (RF) magnetron sputter deposition of hydroxyapatite (HA) coating. The scaffolds with HA coating were characterized by Scanning Electron microscopy, X-ray diffraction. HA coating showed a nanocrystalline structure with the crystallites of an average size of 32±9 nm. The ability of the surface to support adhesion and the proliferation of human mesenchymal stem cells was studied using biological short-term tests in vitro. In according to in vitro assessment, thin HA coating stimulated the attachment and proliferation of cells. Human mesenchymal stem cells cultured on the HA-coated scaffold also formed mineralized nodules.
AB - Custom orthopedic and dental implants may be fabricated by additive manufacturing (AM), for example using electron beam melting technology. This study is focused on the modification of the surface of Ti6Al4V alloy coin-like scaffolds fabricated via AM technology (EBM®) by radio frequency (RF) magnetron sputter deposition of hydroxyapatite (HA) coating. The scaffolds with HA coating were characterized by Scanning Electron microscopy, X-ray diffraction. HA coating showed a nanocrystalline structure with the crystallites of an average size of 32±9 nm. The ability of the surface to support adhesion and the proliferation of human mesenchymal stem cells was studied using biological short-term tests in vitro. In according to in vitro assessment, thin HA coating stimulated the attachment and proliferation of cells. Human mesenchymal stem cells cultured on the HA-coated scaffold also formed mineralized nodules.
KW - Additive manufacturing
KW - Electron beam melting
KW - Hydroxyapatite
KW - Radio frequency (RF) magnetron sputtering
UR - http://www.scopus.com/inward/record.url?scp=85000399629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85000399629&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/MSF.879.2444
DO - 10.4028/www.scientific.net/MSF.879.2444
M3 - Conference contribution
AN - SCOPUS:85000399629
SN - 9783035711295
VL - 879
T3 - Materials Science Forum
SP - 2444
EP - 2449
BT - THERMEC 2016
PB - Trans Tech Publications Ltd
ER -