Abstract
Considering the requirements of medical implantable devices, it is pointed out that biomaterials should play a more sophisticated, longer-term role in the customization and optimization of the material-tissue interface in order to ensure the best long-term clinical outcomes. The aim of this contribution was to assess the performance of silicon carbide-hydroxyapatite in various simulated biological fluids (Dulbecco's modified Eagle's medium (DMEM), simulated body fluid (SBF), and phosphate buffer solution (PBS)) through immersion assays for 21 days at 37 ± 0.5 °C and to evaluate the electrochemical behavior. The coatings were prepared on Ti6Al4V alloy substrates by magnetron sputtering method using two cathodes made of hydroxyapatite and silicon carbide (SiC). After immersion assays the coating's surface was analyzed in terms of morphology, chemical and phase composition, and chemical bonds. According to the electrochemical behavior in the media investigated at 37 ± 0.5 °C, SiC addition inhibits the dissolution of the hydroxyapatite in DMEM acellular media. Furthermore, after adding SiC, the slow degradation of hydroxyapatite in PBS and SBF media as well as biomineralization in DMEM were observed.
| Original language | English |
|---|---|
| Article number | 389 |
| Journal | Coatings |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Jun 2019 |
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Keywords
- DMEM
- Hydroxyapatite
- Magnetron sputtering
- PBS
- SBF
- Silicon
ASJC Scopus subject areas
- Surfaces and Interfaces
- Surfaces, Coatings and Films
- Materials Chemistry
Cite this
In vitro activity assays of sputtered HAp coatings with SiC addition in various simulated biological fluids. / Vladescu, Alina; Pârâu, Anca; Pana, Iulian; Cotrut, Cosmin M.; Constantin, Lidia R.; Braic, Viorel; Vrânceanu, Diana M.
In: Coatings, Vol. 9, No. 6, 389, 01.06.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro activity assays of sputtered HAp coatings with SiC addition in various simulated biological fluids
AU - Vladescu, Alina
AU - Pârâu, Anca
AU - Pana, Iulian
AU - Cotrut, Cosmin M.
AU - Constantin, Lidia R.
AU - Braic, Viorel
AU - Vrânceanu, Diana M.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Considering the requirements of medical implantable devices, it is pointed out that biomaterials should play a more sophisticated, longer-term role in the customization and optimization of the material-tissue interface in order to ensure the best long-term clinical outcomes. The aim of this contribution was to assess the performance of silicon carbide-hydroxyapatite in various simulated biological fluids (Dulbecco's modified Eagle's medium (DMEM), simulated body fluid (SBF), and phosphate buffer solution (PBS)) through immersion assays for 21 days at 37 ± 0.5 °C and to evaluate the electrochemical behavior. The coatings were prepared on Ti6Al4V alloy substrates by magnetron sputtering method using two cathodes made of hydroxyapatite and silicon carbide (SiC). After immersion assays the coating's surface was analyzed in terms of morphology, chemical and phase composition, and chemical bonds. According to the electrochemical behavior in the media investigated at 37 ± 0.5 °C, SiC addition inhibits the dissolution of the hydroxyapatite in DMEM acellular media. Furthermore, after adding SiC, the slow degradation of hydroxyapatite in PBS and SBF media as well as biomineralization in DMEM were observed.
AB - Considering the requirements of medical implantable devices, it is pointed out that biomaterials should play a more sophisticated, longer-term role in the customization and optimization of the material-tissue interface in order to ensure the best long-term clinical outcomes. The aim of this contribution was to assess the performance of silicon carbide-hydroxyapatite in various simulated biological fluids (Dulbecco's modified Eagle's medium (DMEM), simulated body fluid (SBF), and phosphate buffer solution (PBS)) through immersion assays for 21 days at 37 ± 0.5 °C and to evaluate the electrochemical behavior. The coatings were prepared on Ti6Al4V alloy substrates by magnetron sputtering method using two cathodes made of hydroxyapatite and silicon carbide (SiC). After immersion assays the coating's surface was analyzed in terms of morphology, chemical and phase composition, and chemical bonds. According to the electrochemical behavior in the media investigated at 37 ± 0.5 °C, SiC addition inhibits the dissolution of the hydroxyapatite in DMEM acellular media. Furthermore, after adding SiC, the slow degradation of hydroxyapatite in PBS and SBF media as well as biomineralization in DMEM were observed.
KW - DMEM
KW - Hydroxyapatite
KW - Magnetron sputtering
KW - PBS
KW - SBF
KW - Silicon
UR - http://www.scopus.com/inward/record.url?scp=85069786710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069786710&partnerID=8YFLogxK
U2 - 10.3390/COATINGS9060389
DO - 10.3390/COATINGS9060389
M3 - Article
AN - SCOPUS:85069786710
VL - 9
JO - Coatings
JF - Coatings
SN - 2079-6412
IS - 6
M1 - 389
ER -