Immediate recovery of acquired von willebrand syndrome after left ventricular assist device explantation

Implications for heart transplantation

Mary E. Davis, Nicholas A. Haglund, Nicole M. Tricarico, Anton Matafonov, David Gailani, Simon Maltais

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

All patients supported with continuous flow-left ventricular assist devices (CF-LVADs) develop acquired von Willebrand syndrome due to the loss of von Willebrand factor (vWF) high molecular weight (HMW) multimers and this phenomenon has been associated with clinical manifestation of bleeding diatheses. The precise timing of postoperative recovery of HMW multimers and correction of this condition after CF-LVAD explantation and heart transplantation is unknown. We sought to determine the specific timing of HMW multimer recovery by serially quantifying plasma vWF multimer ratios after CF-LVAD explant and orthotopic heart transplantation (OHT) in a patient implanted with a HeartWare ventricular assist device. Using densitometric analysis of multimer patterns, we demonstrated complete recovery of HMW multimers within the first few hours following CF-LVAD explant and OHT. These findings have critical implications in the context of perioperative bleeding diatheses in patients bridged to transplantation with a CF-LVAD.

Original languageEnglish
Pages (from-to)e1-e4
JournalASAIO Journal
Volume61
Issue number1
DOIs
Publication statusPublished - 13 Jan 2015
Externally publishedYes

Fingerprint

Left ventricular assist devices
Heart-Assist Devices
Heart Transplantation
Recovery
Molecular weight
Molecular Weight
von Willebrand Factor
Disease Susceptibility
Hemorrhage
Plasmas
Transplantation

Keywords

  • acquired von Willebrand syndrome
  • cardiac transplantation
  • left ventricular assist device
  • perioperative bleeding

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering
  • Medicine(all)

Cite this

Immediate recovery of acquired von willebrand syndrome after left ventricular assist device explantation : Implications for heart transplantation. / Davis, Mary E.; Haglund, Nicholas A.; Tricarico, Nicole M.; Matafonov, Anton; Gailani, David; Maltais, Simon.

In: ASAIO Journal, Vol. 61, No. 1, 13.01.2015, p. e1-e4.

Research output: Contribution to journalArticle

Davis, Mary E. ; Haglund, Nicholas A. ; Tricarico, Nicole M. ; Matafonov, Anton ; Gailani, David ; Maltais, Simon. / Immediate recovery of acquired von willebrand syndrome after left ventricular assist device explantation : Implications for heart transplantation. In: ASAIO Journal. 2015 ; Vol. 61, No. 1. pp. e1-e4.
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