Hydrolytic Stability of Aqueous Solutions of Salicin

S. V. Nekhoroshev, A. V. Nekhorosheva, A. B. Sabutova, E. Kh Botirov, A. A. Drenin, G. B. Slepchenko, N. V. Gornikov

Research output: Contribution to journalArticlepeer-review

Abstract

The kinetics of salicin acid hydrolysis in aqueous solutions were studied. The salicin content in the reaction mixtures was determined by HPLC with UV detection. The salicin hydrolysis rate depended more on the solution acidity than on the temperature. The dependences of the salicin hydrolysis rate constant on temperature and solution acidity were established. Salicin was most reactive in aqueous solutions at 90°C and pH < 1.0. Salicin preparations could be stored for more than one year without noticeable decomposition at room temperature and pH > 2.0

Original languageEnglish
Pages (from-to)857-860
Number of pages4
JournalPharmaceutical Chemistry Journal
Volume54
Issue number8
DOIs
Publication statusPublished - Nov 2020

Keywords

  • glycoside
  • hydrolysis
  • kinetics
  • salicin
  • storage

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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