Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia

Evgeny A. Ermakov, Svetlana A. Ivanova, Valentina N. Buneva, Georgy A. Nevinsky

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Significant importance of autoimmune changes in the pathogenesis of schizophrenia (SCZ) is not established. Here, we present the first evidence that autoantibodies of 100% SCZ patients possess RNase activity: сCMP > poly(C) > poly(A) > yeast RNA. In addition, we have got an unexpected result: there was revealed site-specific hydrolysis of four known SCZ specific microRNAs (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p) playing an important role in the regulation of several genes functioning. Three major of cleavage sites are located in the microRNA loops or duplex parts directly articulated with the loops. RNase abzymes can contribute to decreasing of microRNAs effects on the functioning of numerous genes and the products of their transcription. Therefore, abzymes with RNase activity may be to some extent important for the development of schizophrenia.

Original languageEnglish
Pages (from-to)153-164
Number of pages12
JournalIUBMB Life
Volume70
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018
Externally publishedYes

Fingerprint

Ribonucleases
MicroRNAs
Hydrolysis
Schizophrenia
Genes
Cytidine Monophosphate
Poly C
Poly A
Transcription
Autoantibodies
Yeast
RNA
Yeasts

Keywords

  • abzymes
  • autoimmune reactions
  • microRNA hydrolysis
  • schizophrenia

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia. / Ermakov, Evgeny A.; Ivanova, Svetlana A.; Buneva, Valentina N.; Nevinsky, Georgy A.

In: IUBMB Life, Vol. 70, No. 2, 01.02.2018, p. 153-164.

Research output: Contribution to journalArticle

Ermakov, Evgeny A. ; Ivanova, Svetlana A. ; Buneva, Valentina N. ; Nevinsky, Georgy A. / Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia. In: IUBMB Life. 2018 ; Vol. 70, No. 2. pp. 153-164.
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