Hybrid systems for oral delivery of a therapeutic neuropeptide

Natalia N. Sudareva, Olga M. Suvorova, Irina I. Tarasenko, Natalia N. Saprykina, Natalia V. Smirnova, Sergey G. Petunov, Andrey S. Radilov, Alexander S. Timin, Evgenia G. Korzhikova-Vlakh, Alexander D. Vilesov

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Several hybrid systems for oral delivery of a therapeutic peptide have been prepared and investigated. Poly(l-glutamic acidco-d-phenylalanine) and silica sub-microparticles, porous CaCO3 microparticles and Lycopodium clavatum spore capsules were employed as the first level carriers included in sodium alginate granules as the second level carriers. Efficiency of the peptide encapsulation and release rate strongly depended on the nature and structure of the carriers.

Original languageEnglish
Pages (from-to)25-27
Number of pages3
JournalMendeleev Communications
Volume30
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020
Externally publishedYes

Keywords

  • alginate granules
  • encapsulation
  • peptide delivery systems
  • poly(amino acids)
  • silica and CaCO sub-microparticles
  • sporopollenin exine capsules

ASJC Scopus subject areas

  • Chemistry(all)

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