Hybrid capsules as efficient non-viral vector for gene delivery into cells

M. V. Zyuzin, A. S. Timin

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)

Abstract

Advances in the field of nanotechnology make it possible to employ nano-and microparticles as delivery carriers of genetic materials. In this study, hollow capsules of different composition were used as non-viral vectors to deliver plasmids into human cervical carcinoma cells (HeLa). Plasmids were encoded to express green fluorescent protein (eGFP) inside cells. Hybrid capsules were produced from degradable polyelectrolytes with an outer silica layer. Capsules were characterized with scanning electron and bright field microscopy. Successful cell transfection was verified with the confocal laser scanning microscope (CLSM).

Original languageEnglish
Article number012182
JournalJournal of Physics: Conference Series
Volume1092
DOIs
Publication statusPublished - 2018
Event3rd International Conference on Metamaterials and Nanophotonics, METANANO 2018 - Sochi, Russian Federation
Duration: 17 Sep 201821 Sep 2018

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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