HPLC Monitoring of Biphenyl Derivatives with UV and Electrochemical Detection Modes

Abstract

A new RP HPLC method for the separation of amino, nitro and hydroxy derivatives of 2- and 4-substituted biphenyls as model genotoxic compounds and their metabolic products has been developed. A newly designed amperometric platinum tubular detector was employed to obtain lower detection limit than with the classical UV detector. The method has been applied to the monitoring the destruction efficiency of the studied genotoxic compounds in laboratory waste, as well as to the determination of 2-hydroxybiphenyl content in tomatoes and in human urine.

Original language	English
Pages (from-to)	805-816
Number of pages	12
Journal	Chemia Analityczna
Volume	48
Issue number	5
Publication status	Published - 16 Dec 2003
Externally published	Yes

Keywords

Aminobiphenyls
Electrochemical detection
HPLC separation
Hydroxybiphenyls
Nitrobiphenyls

ASJC Scopus subject areas

Analytical Chemistry

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title = "HPLC Monitoring of Biphenyl Derivatives with UV and Electrochemical Detection Modes",

abstract = "A new RP HPLC method for the separation of amino, nitro and hydroxy derivatives of 2- and 4-substituted biphenyls as model genotoxic compounds and their metabolic products has been developed. A newly designed amperometric platinum tubular detector was employed to obtain lower detection limit than with the classical UV detector. The method has been applied to the monitoring the destruction efficiency of the studied genotoxic compounds in laboratory waste, as well as to the determination of 2-hydroxybiphenyl content in tomatoes and in human urine.",

keywords = "Aminobiphenyls, Electrochemical detection, HPLC separation, Hydroxybiphenyls, Nitrobiphenyls",

author = "Jiri Zima and Silvie Vaingatova and Jiri Barek and Jiri Brichac",

year = "2003",

month = dec,

day = "16",

language = "English",

volume = "48",

pages = "805--816",

journal = "Chemia Analityczna",

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publisher = "Polskie Towarzystwo Chemiczne",

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TY - JOUR

T1 - HPLC Monitoring of Biphenyl Derivatives with UV and Electrochemical Detection Modes

AU - Zima, Jiri

AU - Vaingatova, Silvie

AU - Barek, Jiri

AU - Brichac, Jiri

PY - 2003/12/16

Y1 - 2003/12/16

N2 - A new RP HPLC method for the separation of amino, nitro and hydroxy derivatives of 2- and 4-substituted biphenyls as model genotoxic compounds and their metabolic products has been developed. A newly designed amperometric platinum tubular detector was employed to obtain lower detection limit than with the classical UV detector. The method has been applied to the monitoring the destruction efficiency of the studied genotoxic compounds in laboratory waste, as well as to the determination of 2-hydroxybiphenyl content in tomatoes and in human urine.

AB - A new RP HPLC method for the separation of amino, nitro and hydroxy derivatives of 2- and 4-substituted biphenyls as model genotoxic compounds and their metabolic products has been developed. A newly designed amperometric platinum tubular detector was employed to obtain lower detection limit than with the classical UV detector. The method has been applied to the monitoring the destruction efficiency of the studied genotoxic compounds in laboratory waste, as well as to the determination of 2-hydroxybiphenyl content in tomatoes and in human urine.

KW - Aminobiphenyls

KW - Electrochemical detection

KW - HPLC separation

KW - Hydroxybiphenyls

KW - Nitrobiphenyls

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M3 - Article

AN - SCOPUS:0344628511

VL - 48

SP - 805

EP - 816

JO - Chemia Analityczna

JF - Chemia Analityczna

SN - 0009-2223

IS - 5

ER -