Abstract
A new RP HPLC method for the separation of amino, nitro and hydroxy derivatives of 2- and 4-substituted biphenyls as model genotoxic compounds and their metabolic products has been developed. A newly designed amperometric platinum tubular detector was employed to obtain lower detection limit than with the classical UV detector. The method has been applied to the monitoring the destruction efficiency of the studied genotoxic compounds in laboratory waste, as well as to the determination of 2-hydroxybiphenyl content in tomatoes and in human urine.
| Original language | English |
|---|---|
| Pages (from-to) | 805-816 |
| Number of pages | 12 |
| Journal | Chemia Analityczna |
| Volume | 48 |
| Issue number | 5 |
| Publication status | Published - 16 Dec 2003 |
| Externally published | Yes |
Fingerprint
Keywords
- Aminobiphenyls
- Electrochemical detection
- HPLC separation
- Hydroxybiphenyls
- Nitrobiphenyls
ASJC Scopus subject areas
- Analytical Chemistry
Cite this
HPLC Monitoring of Biphenyl Derivatives with UV and Electrochemical Detection Modes. / Zima, Jiri; Vaingatova, Silvie; Barek, Jiri; Brichac, Jiri.
In: Chemia Analityczna, Vol. 48, No. 5, 16.12.2003, p. 805-816.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HPLC Monitoring of Biphenyl Derivatives with UV and Electrochemical Detection Modes
AU - Zima, Jiri
AU - Vaingatova, Silvie
AU - Barek, Jiri
AU - Brichac, Jiri
PY - 2003/12/16
Y1 - 2003/12/16
N2 - A new RP HPLC method for the separation of amino, nitro and hydroxy derivatives of 2- and 4-substituted biphenyls as model genotoxic compounds and their metabolic products has been developed. A newly designed amperometric platinum tubular detector was employed to obtain lower detection limit than with the classical UV detector. The method has been applied to the monitoring the destruction efficiency of the studied genotoxic compounds in laboratory waste, as well as to the determination of 2-hydroxybiphenyl content in tomatoes and in human urine.
AB - A new RP HPLC method for the separation of amino, nitro and hydroxy derivatives of 2- and 4-substituted biphenyls as model genotoxic compounds and their metabolic products has been developed. A newly designed amperometric platinum tubular detector was employed to obtain lower detection limit than with the classical UV detector. The method has been applied to the monitoring the destruction efficiency of the studied genotoxic compounds in laboratory waste, as well as to the determination of 2-hydroxybiphenyl content in tomatoes and in human urine.
KW - Aminobiphenyls
KW - Electrochemical detection
KW - HPLC separation
KW - Hydroxybiphenyls
KW - Nitrobiphenyls
UR - http://www.scopus.com/inward/record.url?scp=0344628511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0344628511&partnerID=8YFLogxK
M3 - Article
VL - 48
SP - 805
EP - 816
JO - Chemia Analityczna
JF - Chemia Analityczna
SN - 0009-2223
IS - 5
ER -