HPLC Monitoring of Biphenyl Derivatives with UV and Electrochemical Detection Modes

Jiri Zima, Silvie Vaingatova, Jiri Barek, Jiri Brichac

Research output: Contribution to journalArticle

6 Citations (Scopus)


A new RP HPLC method for the separation of amino, nitro and hydroxy derivatives of 2- and 4-substituted biphenyls as model genotoxic compounds and their metabolic products has been developed. A newly designed amperometric platinum tubular detector was employed to obtain lower detection limit than with the classical UV detector. The method has been applied to the monitoring the destruction efficiency of the studied genotoxic compounds in laboratory waste, as well as to the determination of 2-hydroxybiphenyl content in tomatoes and in human urine.

Original languageEnglish
Pages (from-to)805-816
Number of pages12
JournalChemia Analityczna
Issue number5
Publication statusPublished - 16 Dec 2003
Externally publishedYes



  • Aminobiphenyls
  • Electrochemical detection
  • HPLC separation
  • Hydroxybiphenyls
  • Nitrobiphenyls

ASJC Scopus subject areas

  • Analytical Chemistry

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