Holmium-DOTA as a responsive relaxation paramagnetic probe for NMR/MRI control of local temperature at high magnetic fields

Abstract

In this work, the temperature dependence of Curie-spin (CS) contribution to the relaxation rate was studied by ¹ H NMR under magnetic fields of 7.05 and 18.79 T using the Ho complex with DOTA as an example. This is the first example of the detailed study of the temperature dependence of Curie-spin contribution to the paramagnetic transverse relaxation rate enhancements (CS-PTRRE) in lanthanide complexes other than dysprosium, taking into account the magnetic field strength and change of viscosity with temperature. It was found that due to the substantial temperature dependence of CS-PTRRE the Ho complex with DOTA is the first example of a temperature sensitive relaxation paramagnetic lanthanide probe for in situ temperature control by NMR/MRI in water environment at high magnetic fields.

Original language	English
Pages (from-to)	57-60
Number of pages	4
Journal	Inorganica Chimica Acta
Volume	493
DOIs	https://doi.org/10.1016/j.ica.2019.04.003
Publication status	Published - 1 Jul 2019
Externally published	Yes

Keywords

Complexes of lanthanides
DOTA
Temperature sensitive NMR/MRI lanthanide paramagnetic relaxation probe
The Curie-spin contribution to the paramagnetic relaxation rate enhancements

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.ica.2019.04.003

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@article{b8100be33703403bb6804244ea5d3384,

title = "Holmium-DOTA as a responsive relaxation paramagnetic probe for NMR/MRI control of local temperature at high magnetic fields",

abstract = " In this work, the temperature dependence of Curie-spin (CS) contribution to the relaxation rate was studied by 1 H NMR under magnetic fields of 7.05 and 18.79 T using the Ho complex with DOTA as an example. This is the first example of the detailed study of the temperature dependence of Curie-spin contribution to the paramagnetic transverse relaxation rate enhancements (CS-PTRRE) in lanthanide complexes other than dysprosium, taking into account the magnetic field strength and change of viscosity with temperature. It was found that due to the substantial temperature dependence of CS-PTRRE the Ho complex with DOTA is the first example of a temperature sensitive relaxation paramagnetic lanthanide probe for in situ temperature control by NMR/MRI in water environment at high magnetic fields. ",

keywords = "Complexes of lanthanides, DOTA, Temperature sensitive NMR/MRI lanthanide paramagnetic relaxation probe, The Curie-spin contribution to the paramagnetic relaxation rate enhancements",

author = "Babailov, {Sergey P.} and Zapolotsky, {Eugeny N.} and Basova, {Tamara V.}",

year = "2019",

month = jul,

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doi = "10.1016/j.ica.2019.04.003",

language = "English",

volume = "493",

pages = "57--60",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Holmium-DOTA as a responsive relaxation paramagnetic probe for NMR/MRI control of local temperature at high magnetic fields

AU - Babailov, Sergey P.

AU - Zapolotsky, Eugeny N.

AU - Basova, Tamara V.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - In this work, the temperature dependence of Curie-spin (CS) contribution to the relaxation rate was studied by 1 H NMR under magnetic fields of 7.05 and 18.79 T using the Ho complex with DOTA as an example. This is the first example of the detailed study of the temperature dependence of Curie-spin contribution to the paramagnetic transverse relaxation rate enhancements (CS-PTRRE) in lanthanide complexes other than dysprosium, taking into account the magnetic field strength and change of viscosity with temperature. It was found that due to the substantial temperature dependence of CS-PTRRE the Ho complex with DOTA is the first example of a temperature sensitive relaxation paramagnetic lanthanide probe for in situ temperature control by NMR/MRI in water environment at high magnetic fields.

AB - In this work, the temperature dependence of Curie-spin (CS) contribution to the relaxation rate was studied by 1 H NMR under magnetic fields of 7.05 and 18.79 T using the Ho complex with DOTA as an example. This is the first example of the detailed study of the temperature dependence of Curie-spin contribution to the paramagnetic transverse relaxation rate enhancements (CS-PTRRE) in lanthanide complexes other than dysprosium, taking into account the magnetic field strength and change of viscosity with temperature. It was found that due to the substantial temperature dependence of CS-PTRRE the Ho complex with DOTA is the first example of a temperature sensitive relaxation paramagnetic lanthanide probe for in situ temperature control by NMR/MRI in water environment at high magnetic fields.

KW - Complexes of lanthanides

KW - DOTA

KW - Temperature sensitive NMR/MRI lanthanide paramagnetic relaxation probe

KW - The Curie-spin contribution to the paramagnetic relaxation rate enhancements

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JO - Inorganica Chimica Acta

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