Holmium-DOTA as a responsive relaxation paramagnetic probe for NMR/MRI control of local temperature at high magnetic fields

Sergey P. Babailov, Eugeny N. Zapolotsky, Tamara V. Basova

Research output: Contribution to journalArticle

Abstract

In this work, the temperature dependence of Curie-spin (CS) contribution to the relaxation rate was studied by 1 H NMR under magnetic fields of 7.05 and 18.79 T using the Ho complex with DOTA as an example. This is the first example of the detailed study of the temperature dependence of Curie-spin contribution to the paramagnetic transverse relaxation rate enhancements (CS-PTRRE) in lanthanide complexes other than dysprosium, taking into account the magnetic field strength and change of viscosity with temperature. It was found that due to the substantial temperature dependence of CS-PTRRE the Ho complex with DOTA is the first example of a temperature sensitive relaxation paramagnetic lanthanide probe for in situ temperature control by NMR/MRI in water environment at high magnetic fields.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalInorganica Chimica Acta
Volume493
DOIs
Publication statusPublished - 1 Jul 2019
Externally publishedYes

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Keywords

  • Complexes of lanthanides
  • DOTA
  • Temperature sensitive NMR/MRI lanthanide paramagnetic relaxation probe
  • The Curie-spin contribution to the paramagnetic relaxation rate enhancements

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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