Holmium-DOTA as a responsive relaxation paramagnetic probe for NMR/MRI control of local temperature at high magnetic fields

Sergey P. Babailov, Eugeny N. Zapolotsky, Tamara V. Basova

Research output: Contribution to journalArticle

Abstract

In this work, the temperature dependence of Curie-spin (CS) contribution to the relaxation rate was studied by 1 H NMR under magnetic fields of 7.05 and 18.79 T using the Ho complex with DOTA as an example. This is the first example of the detailed study of the temperature dependence of Curie-spin contribution to the paramagnetic transverse relaxation rate enhancements (CS-PTRRE) in lanthanide complexes other than dysprosium, taking into account the magnetic field strength and change of viscosity with temperature. It was found that due to the substantial temperature dependence of CS-PTRRE the Ho complex with DOTA is the first example of a temperature sensitive relaxation paramagnetic lanthanide probe for in situ temperature control by NMR/MRI in water environment at high magnetic fields.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalInorganica Chimica Acta
Volume493
DOIs
Publication statusPublished - 1 Jul 2019
Externally publishedYes

Fingerprint

Holmium
holmium
Magnetic resonance imaging
Nuclear magnetic resonance
Magnetic fields
temperature dependence
nuclear magnetic resonance
probes
Lanthanoid Series Elements
magnetic fields
Rare earth elements
dysprosium
temperature control
Dysprosium
Temperature
temperature
field strength
viscosity
Temperature control
augmentation

Keywords

  • Complexes of lanthanides
  • DOTA
  • Temperature sensitive NMR/MRI lanthanide paramagnetic relaxation probe
  • The Curie-spin contribution to the paramagnetic relaxation rate enhancements

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Holmium-DOTA as a responsive relaxation paramagnetic probe for NMR/MRI control of local temperature at high magnetic fields. / Babailov, Sergey P.; Zapolotsky, Eugeny N.; Basova, Tamara V.

In: Inorganica Chimica Acta, Vol. 493, 01.07.2019, p. 57-60.

Research output: Contribution to journalArticle

Babailov, Sergey P. ; Zapolotsky, Eugeny N. ; Basova, Tamara V. / Holmium-DOTA as a responsive relaxation paramagnetic probe for NMR/MRI control of local temperature at high magnetic fields. In: Inorganica Chimica Acta. 2019 ; Vol. 493. pp. 57-60.
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