Abstract
Previously the NMR signals were assigned and molecular dynamics of the holmium complexes with DOTA was studied using 1H NMR [Babailov S.P., Dubovskii P.V., Zapolotsky E.N. Polyhedron 2014, 79, 277-283 (DOI: 10.1016/j. poly.2014.04.067)]. It is known that lanthanide chelates with this ligand are very thermostable. The gadolinium complex with DOTA is used in clinic as relaxation contrast agent. Nevertheless, temperature dependence of paramagnetic properties of holmium complex with DOTA was not investigated in detail. In the paper the 1H NMR method is used to study the temperature dependence of the lanthanide-induced shifts (LISs) for complex [Ho(H2O)(DOTA)]-. It was found that the LISs have a linear dependence on 1/T. The studied coordination compound may serve as the most sensitive 1H NMR lanthanide paramagnetic probes (as compared with other complexes of 4f- and d-elements both in organic and aqueous solutions) for in situ temperature control in solutions. The coordination compound studied may also have a medical use for determining the local temperature of the body using MRI.
| Original language | English |
|---|---|
| Pages (from-to) | 277-281 |
| Number of pages | 5 |
| Journal | Macroheterocycles |
| Volume | 9 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- Chelate ligands
- DOTA
- Lanthanide complexes
- Lanthanide-induced shifts
- Molecular magnet
- NMR
- Polyaminocarboxylic ligands
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry
Cite this
Holmium complex with DOTA as NMR super-sensitive temperature sensor reagent for spectroscopic and tomography monitoring of aqueous systems. / Babailov, Sergey P.
In: Macroheterocycles, Vol. 9, No. 3, 2016, p. 277-281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Holmium complex with DOTA as NMR super-sensitive temperature sensor reagent for spectroscopic and tomography monitoring of aqueous systems
AU - Babailov, Sergey P.
PY - 2016
Y1 - 2016
N2 - Previously the NMR signals were assigned and molecular dynamics of the holmium complexes with DOTA was studied using 1H NMR [Babailov S.P., Dubovskii P.V., Zapolotsky E.N. Polyhedron 2014, 79, 277-283 (DOI: 10.1016/j. poly.2014.04.067)]. It is known that lanthanide chelates with this ligand are very thermostable. The gadolinium complex with DOTA is used in clinic as relaxation contrast agent. Nevertheless, temperature dependence of paramagnetic properties of holmium complex with DOTA was not investigated in detail. In the paper the 1H NMR method is used to study the temperature dependence of the lanthanide-induced shifts (LISs) for complex [Ho(H2O)(DOTA)]-. It was found that the LISs have a linear dependence on 1/T. The studied coordination compound may serve as the most sensitive 1H NMR lanthanide paramagnetic probes (as compared with other complexes of 4f- and d-elements both in organic and aqueous solutions) for in situ temperature control in solutions. The coordination compound studied may also have a medical use for determining the local temperature of the body using MRI.
AB - Previously the NMR signals were assigned and molecular dynamics of the holmium complexes with DOTA was studied using 1H NMR [Babailov S.P., Dubovskii P.V., Zapolotsky E.N. Polyhedron 2014, 79, 277-283 (DOI: 10.1016/j. poly.2014.04.067)]. It is known that lanthanide chelates with this ligand are very thermostable. The gadolinium complex with DOTA is used in clinic as relaxation contrast agent. Nevertheless, temperature dependence of paramagnetic properties of holmium complex with DOTA was not investigated in detail. In the paper the 1H NMR method is used to study the temperature dependence of the lanthanide-induced shifts (LISs) for complex [Ho(H2O)(DOTA)]-. It was found that the LISs have a linear dependence on 1/T. The studied coordination compound may serve as the most sensitive 1H NMR lanthanide paramagnetic probes (as compared with other complexes of 4f- and d-elements both in organic and aqueous solutions) for in situ temperature control in solutions. The coordination compound studied may also have a medical use for determining the local temperature of the body using MRI.
KW - Chelate ligands
KW - DOTA
KW - Lanthanide complexes
KW - Lanthanide-induced shifts
KW - Molecular magnet
KW - NMR
KW - Polyaminocarboxylic ligands
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UR - http://www.scopus.com/inward/citedby.url?scp=85005952359&partnerID=8YFLogxK
U2 - 10.6060/mhc160961b
DO - 10.6060/mhc160961b
M3 - Article
VL - 9
SP - 277
EP - 281
JO - Macroheterocycles
JF - Macroheterocycles
SN - 1998-9539
IS - 3
ER -