Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection

Ekaterina Lengert, Alexey M. Yashchenok, Vsevolod Atkin, Ales Lapanje, Dmitry A. Gorin, Gleb B. Sukhorukov, Bogdan V. Parakhonskiy

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Multifunctional silver alginate hydrogel microspheres are assembled via a template assisted approach using calcium carbonate cores. Sodium alginate is immobilized into the highly porous structure of calcium carbonate microspheres followed by cross-linking in the presence of silver ions. The simultaneous processes of the growth of silver nanoparticles in the alginate matrix and the removal of the calcium carbonate template are triggered by ascorbic acid. The abundance of silver nanoparticles and their interparticular junctions in the alginate network allow for the detection of solutes using Raman spectroscopy using the surface of the plasmonic microspheres. Rhodamine B was used to illustrate the potential applications of such multifunctional plasmonic alginate hydrogel microspheres for sensing at low concentrations. A proof of principle for using such particles for the quick identification of microorganisms is then demonstrated using the Escherichia coli bacterium.

Original languageEnglish
Pages (from-to)20447-20452
Number of pages6
JournalRSC Advances
Volume6
Issue number24
DOIs
Publication statusPublished - 2016
Externally publishedYes

Fingerprint

Alginate
Microspheres
Drug delivery
Silver
Raman scattering
Calcium carbonate
Calcium Carbonate
rhodamine B
Hydrogels
Hydrogel
Nanoparticles
Sodium alginate
Ascorbic acid
Microorganisms
Escherichia coli
Raman spectroscopy
Bacteria
Ascorbic Acid
alginic acid
Ions

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Lengert, E., Yashchenok, A. M., Atkin, V., Lapanje, A., Gorin, D. A., Sukhorukov, G. B., & Parakhonskiy, B. V. (2016). Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection. RSC Advances, 6(24), 20447-20452. https://doi.org/10.1039/c6ra02019d

Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection. / Lengert, Ekaterina; Yashchenok, Alexey M.; Atkin, Vsevolod; Lapanje, Ales; Gorin, Dmitry A.; Sukhorukov, Gleb B.; Parakhonskiy, Bogdan V.

In: RSC Advances, Vol. 6, No. 24, 2016, p. 20447-20452.

Research output: Contribution to journalArticle

Lengert, E, Yashchenok, AM, Atkin, V, Lapanje, A, Gorin, DA, Sukhorukov, GB & Parakhonskiy, BV 2016, 'Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection', RSC Advances, vol. 6, no. 24, pp. 20447-20452. https://doi.org/10.1039/c6ra02019d
Lengert, Ekaterina ; Yashchenok, Alexey M. ; Atkin, Vsevolod ; Lapanje, Ales ; Gorin, Dmitry A. ; Sukhorukov, Gleb B. ; Parakhonskiy, Bogdan V. / Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection. In: RSC Advances. 2016 ; Vol. 6, No. 24. pp. 20447-20452.
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