High yield [125I]iodide-labeling of iodinated carboranes by palladium-catalyzed isotopic exchange

Karl Johan Winberg, Gemma Barberà, Ludvig Eriksson, Francesc Teixidor, Vladimir Tolmachev, Clara Viñas, Stefan Sjöberg

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

We have recently shown the feasibility of palladium-catalyzed isotopic exchange between [125I]iodide and 2-iodo-para-carborane. In this work we have modified the methodology and extended its application to a wider range of iodinated carboranes. Thus, by using Herrmann's catalyst in toluene at 100 °C, 2-I-p-, 3-I- o -, 9-I-o -, 9-I- m -carborane, 1-phenyl-3-I- o -carborane and 1,2-diphenyl-3-I-o -carborane have been radiolabeled with 125 iodine in high to excellent yields.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalJournal of Organometallic Chemistry
Volume680
Issue number1-2
DOIs
Publication statusPublished - 29 Aug 2003
Externally publishedYes

Keywords

  • [I]iodide
  • Catalyst
  • Iodinated carboranes
  • Isotopic exchange
  • Labeling
  • Palladium

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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