Heterocyclic analogs of combretastatin A-4

S. F. Vasilevsky, M. P. Davydova, G. A. Tolstikov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A novel route is proposed for the synthesis of heterocyclic analogs of the naturally occurring combretastatin A-4 based on the reaction of α-acetylenic ketones with polyfunctional nucleophiles (hydroxylamine, hydrazine, guanidine). Previously unknown combretastatin A-4 analogs with azole and azine bridges were obtained.

Original languageEnglish
Pages (from-to)1257-1261
Number of pages5
JournalChemistry of Heterocyclic Compounds
Volume44
Issue number10
DOIs
Publication statusPublished - 1 Oct 2008
Externally publishedYes

Fingerprint

hydrazine
Azoles
Nucleophiles
Hydroxylamine
Guanidine
Ketones
fosbretabulin

Keywords

  • Acetylenes
  • Combretastatin A-4
  • Cross-coupling
  • Heterocyclization
  • Homogeneous catalysis

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Heterocyclic analogs of combretastatin A-4. / Vasilevsky, S. F.; Davydova, M. P.; Tolstikov, G. A.

In: Chemistry of Heterocyclic Compounds, Vol. 44, No. 10, 01.10.2008, p. 1257-1261.

Research output: Contribution to journalArticle

Vasilevsky, S. F. ; Davydova, M. P. ; Tolstikov, G. A. / Heterocyclic analogs of combretastatin A-4. In: Chemistry of Heterocyclic Compounds. 2008 ; Vol. 44, No. 10. pp. 1257-1261.
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