Heterocyclic analogs of combretastatin A-4

S. F. Vasilevsky, M. P. Davydova, G. A. Tolstikov

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A novel route is proposed for the synthesis of heterocyclic analogs of the naturally occurring combretastatin A-4 based on the reaction of α-acetylenic ketones with polyfunctional nucleophiles (hydroxylamine, hydrazine, guanidine). Previously unknown combretastatin A-4 analogs with azole and azine bridges were obtained.

Original languageEnglish
Pages (from-to)1257-1261
Number of pages5
JournalChemistry of Heterocyclic Compounds
Issue number10
Publication statusPublished - 1 Oct 2008
Externally publishedYes


  • Acetylenes
  • Combretastatin A-4
  • Cross-coupling
  • Heterocyclization
  • Homogeneous catalysis

ASJC Scopus subject areas

  • Organic Chemistry

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