Hepatoprotective Properties of Native Humic Acids Isolated from Lowland Peat of Tomsk Region

M. V. Belousov, R. R. Akhmedzhanov, M. V. Zykova, A. M. Gur'ev, M. S. Yusubov

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Abstract

The hepatoprotective properties of humic acids from lowland peat of Tomsk region were studied experimentally. It was established that native humic acids of peat (HAP) exhibited pronounced hepatoprotective activity against acute CCl₄ hepatitis. The results showed that intragastric injection of HAP prevented damage from CCl₄ to the metabolic and morphologic parameters of rat liver. The rates of lipoxidation and destruction of hepatocyte membranes and the manifestation of cytolytic syndrome decreased substantially. Liver excretory function improved. Fibrous structures did not develop in livers of experimental animals. The hepatoprotective action of HAP may be due to their pronounced antioxidant properties.

Original language	English
Pages (from-to)	249-252
Number of pages	4
Journal	Pharmaceutical Chemistry Journal
Volume	48
Issue number	4
DOIs	https://doi.org/10.1007/s11094-014-1088-5
Publication status	Published - Jul 2014

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Keywords

Hepatoprotectors
Humic acids
Peat

ASJC Scopus subject areas

Drug Discovery
Pharmacology

Cite this

Belousov, M. V., Akhmedzhanov, R. R., Zykova, M. V., Gur'ev, A. M., & Yusubov, M. S. (2014). Hepatoprotective Properties of Native Humic Acids Isolated from Lowland Peat of Tomsk Region. Pharmaceutical Chemistry Journal, 48(4), 249-252. https://doi.org/10.1007/s11094-014-1088-5

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abstract = "The hepatoprotective properties of humic acids from lowland peat of Tomsk region were studied experimentally. It was established that native humic acids of peat (HAP) exhibited pronounced hepatoprotective activity against acute CCl4 hepatitis. The results showed that intragastric injection of HAP prevented damage from CCl4 to the metabolic and morphologic parameters of rat liver. The rates of lipoxidation and destruction of hepatocyte membranes and the manifestation of cytolytic syndrome decreased substantially. Liver excretory function improved. Fibrous structures did not develop in livers of experimental animals. The hepatoprotective action of HAP may be due to their pronounced antioxidant properties.",

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AU - Gur'ev, A. M.

AU - Yusubov, M. S.

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10.1007/s11094-014-1088-5