Hepatoprotective Properties of Native Humic Acids Isolated from Lowland Peat of Tomsk Region

M. V. Belousov, R. R. Akhmedzhanov, M. V. Zykova, A. M. Gur'ev, M. S. Yusubov

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Abstract

The hepatoprotective properties of humic acids from lowland peat of Tomsk region were studied experimentally. It was established that native humic acids of peat (HAP) exhibited pronounced hepatoprotective activity against acute CCl4 hepatitis. The results showed that intragastric injection of HAP prevented damage from CCl4 to the metabolic and morphologic parameters of rat liver. The rates of lipoxidation and destruction of hepatocyte membranes and the manifestation of cytolytic syndrome decreased substantially. Liver excretory function improved. Fibrous structures did not develop in livers of experimental animals. The hepatoprotective action of HAP may be due to their pronounced antioxidant properties.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalPharmaceutical Chemistry Journal
Volume48
Issue number4
DOIs
Publication statusPublished - Jul 2014

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Keywords

  • Hepatoprotectors
  • Humic acids
  • Peat

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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