Abstract
The hepatoprotective properties of humic acids from lowland peat of Tomsk region were studied experimentally. It was established that native humic acids of peat (HAP) exhibited pronounced hepatoprotective activity against acute CCl4 hepatitis. The results showed that intragastric injection of HAP prevented damage from CCl4 to the metabolic and morphologic parameters of rat liver. The rates of lipoxidation and destruction of hepatocyte membranes and the manifestation of cytolytic syndrome decreased substantially. Liver excretory function improved. Fibrous structures did not develop in livers of experimental animals. The hepatoprotective action of HAP may be due to their pronounced antioxidant properties.
| Original language | English |
|---|---|
| Pages (from-to) | 249-252 |
| Number of pages | 4 |
| Journal | Pharmaceutical Chemistry Journal |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2014 |
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Keywords
- Hepatoprotectors
- Humic acids
- Peat
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
Cite this
Hepatoprotective Properties of Native Humic Acids Isolated from Lowland Peat of Tomsk Region. / Belousov, M. V.; Akhmedzhanov, R. R.; Zykova, M. V.; Gur'ev, A. M.; Yusubov, M. S.
In: Pharmaceutical Chemistry Journal, Vol. 48, No. 4, 07.2014, p. 249-252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hepatoprotective Properties of Native Humic Acids Isolated from Lowland Peat of Tomsk Region
AU - Belousov, M. V.
AU - Akhmedzhanov, R. R.
AU - Zykova, M. V.
AU - Gur'ev, A. M.
AU - Yusubov, M. S.
PY - 2014/7
Y1 - 2014/7
N2 - The hepatoprotective properties of humic acids from lowland peat of Tomsk region were studied experimentally. It was established that native humic acids of peat (HAP) exhibited pronounced hepatoprotective activity against acute CCl4 hepatitis. The results showed that intragastric injection of HAP prevented damage from CCl4 to the metabolic and morphologic parameters of rat liver. The rates of lipoxidation and destruction of hepatocyte membranes and the manifestation of cytolytic syndrome decreased substantially. Liver excretory function improved. Fibrous structures did not develop in livers of experimental animals. The hepatoprotective action of HAP may be due to their pronounced antioxidant properties.
AB - The hepatoprotective properties of humic acids from lowland peat of Tomsk region were studied experimentally. It was established that native humic acids of peat (HAP) exhibited pronounced hepatoprotective activity against acute CCl4 hepatitis. The results showed that intragastric injection of HAP prevented damage from CCl4 to the metabolic and morphologic parameters of rat liver. The rates of lipoxidation and destruction of hepatocyte membranes and the manifestation of cytolytic syndrome decreased substantially. Liver excretory function improved. Fibrous structures did not develop in livers of experimental animals. The hepatoprotective action of HAP may be due to their pronounced antioxidant properties.
KW - Hepatoprotectors
KW - Humic acids
KW - Peat
UR - http://www.scopus.com/inward/record.url?scp=84907320745&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907320745&partnerID=8YFLogxK
U2 - 10.1007/s11094-014-1088-5
DO - 10.1007/s11094-014-1088-5
M3 - Article
VL - 48
SP - 249
EP - 252
JO - Pharmaceutical Chemistry Journal
JF - Pharmaceutical Chemistry Journal
SN - 0091-150X
IS - 4
ER -