Heart rate variability in preterm infants and maternal smoking during pregnancy

Gérard Thiriez, Malika Bouhaddi, Laurent Mourot, François Nobili, Jacques Olivier Fortrat, Alain Menget, Patricia Franco, Jacques Regnard

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: Tobacco smoke exposure increases the risk of premature birth and of dying of sudden infant death syndrome (SIDS). Prematurity significantly increases the risk of dying of SIDS, but mechanisms underlying this epidemiological finding are unclear. The cumulated effect of both prematurity and prenatal exposure to nicotine on autonomic heart rate control has not been studied. Methods: Using coarse-graining spectral analysis, we compared heart rate variability (HRV) indices of preterm newborns at 33-34 weeks post-conceptional age from smoking (n = 19) and non-smoking (n = 21) mothers. Assessment of tobacco exposure relied on maternal reports and newborns cotinine analysis. We observed how indicators of HRV depended on gestational age at birth. Results: At 33-34 weeks postconceptional age, the newborns from smoking mothers had lower HRV low frequency power normalised to the total spectral power (LF/TP) than the control group (median values: 8% vs. 15% respectively, p < 0.02). In the non-smoking group, RR-interval values and total HRV power were correlated with gestational age at birth, with a shorter RR and a lower total HRV power in lesser gestational ages (ρ = 0.67, p = 0.03, ρ = 0.71, p = 0.003 respectively). This correlation was not observed for RR values in the group with smoking mothers.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalClinical Autonomic Research
Volume19
Issue number3
DOIs
Publication statusPublished - 1 Jun 2009
Externally publishedYes

Fingerprint

Premature Infants
Heart Rate
Smoking
Mothers
Pregnancy
Gestational Age
Sudden Infant Death
Newborn Infant
Tobacco
Parturition
Cotinine
Premature Birth
Nicotine
Smoke
Control Groups
Power (Psychology)

Keywords

  • Autonomic nervous system
  • Cigarette smoking
  • Heart rate variability
  • Premature infant
  • Sudden infant death syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Endocrine and Autonomic Systems

Cite this

Thiriez, G., Bouhaddi, M., Mourot, L., Nobili, F., Fortrat, J. O., Menget, A., ... Regnard, J. (2009). Heart rate variability in preterm infants and maternal smoking during pregnancy. Clinical Autonomic Research, 19(3), 149-156. https://doi.org/10.1007/s10286-009-0003-8

Heart rate variability in preterm infants and maternal smoking during pregnancy. / Thiriez, Gérard; Bouhaddi, Malika; Mourot, Laurent; Nobili, François; Fortrat, Jacques Olivier; Menget, Alain; Franco, Patricia; Regnard, Jacques.

In: Clinical Autonomic Research, Vol. 19, No. 3, 01.06.2009, p. 149-156.

Research output: Contribution to journalArticle

Thiriez, G, Bouhaddi, M, Mourot, L, Nobili, F, Fortrat, JO, Menget, A, Franco, P & Regnard, J 2009, 'Heart rate variability in preterm infants and maternal smoking during pregnancy', Clinical Autonomic Research, vol. 19, no. 3, pp. 149-156. https://doi.org/10.1007/s10286-009-0003-8
Thiriez, Gérard ; Bouhaddi, Malika ; Mourot, Laurent ; Nobili, François ; Fortrat, Jacques Olivier ; Menget, Alain ; Franco, Patricia ; Regnard, Jacques. / Heart rate variability in preterm infants and maternal smoking during pregnancy. In: Clinical Autonomic Research. 2009 ; Vol. 19, No. 3. pp. 149-156.
@article{0b033d6bffc14608863b2186b9948911,
title = "Heart rate variability in preterm infants and maternal smoking during pregnancy",
abstract = "Objective: Tobacco smoke exposure increases the risk of premature birth and of dying of sudden infant death syndrome (SIDS). Prematurity significantly increases the risk of dying of SIDS, but mechanisms underlying this epidemiological finding are unclear. The cumulated effect of both prematurity and prenatal exposure to nicotine on autonomic heart rate control has not been studied. Methods: Using coarse-graining spectral analysis, we compared heart rate variability (HRV) indices of preterm newborns at 33-34 weeks post-conceptional age from smoking (n = 19) and non-smoking (n = 21) mothers. Assessment of tobacco exposure relied on maternal reports and newborns cotinine analysis. We observed how indicators of HRV depended on gestational age at birth. Results: At 33-34 weeks postconceptional age, the newborns from smoking mothers had lower HRV low frequency power normalised to the total spectral power (LF/TP) than the control group (median values: 8{\%} vs. 15{\%} respectively, p < 0.02). In the non-smoking group, RR-interval values and total HRV power were correlated with gestational age at birth, with a shorter RR and a lower total HRV power in lesser gestational ages (ρ = 0.67, p = 0.03, ρ = 0.71, p = 0.003 respectively). This correlation was not observed for RR values in the group with smoking mothers.",
keywords = "Autonomic nervous system, Cigarette smoking, Heart rate variability, Premature infant, Sudden infant death syndrome",
author = "G{\'e}rard Thiriez and Malika Bouhaddi and Laurent Mourot and Fran{\cc}ois Nobili and Fortrat, {Jacques Olivier} and Alain Menget and Patricia Franco and Jacques Regnard",
year = "2009",
month = "6",
day = "1",
doi = "10.1007/s10286-009-0003-8",
language = "English",
volume = "19",
pages = "149--156",
journal = "Clinical Autonomic Research",
issn = "0959-9851",
publisher = "D. Steinkopff-Verlag",
number = "3",

}

TY - JOUR

T1 - Heart rate variability in preterm infants and maternal smoking during pregnancy

AU - Thiriez, Gérard

AU - Bouhaddi, Malika

AU - Mourot, Laurent

AU - Nobili, François

AU - Fortrat, Jacques Olivier

AU - Menget, Alain

AU - Franco, Patricia

AU - Regnard, Jacques

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Objective: Tobacco smoke exposure increases the risk of premature birth and of dying of sudden infant death syndrome (SIDS). Prematurity significantly increases the risk of dying of SIDS, but mechanisms underlying this epidemiological finding are unclear. The cumulated effect of both prematurity and prenatal exposure to nicotine on autonomic heart rate control has not been studied. Methods: Using coarse-graining spectral analysis, we compared heart rate variability (HRV) indices of preterm newborns at 33-34 weeks post-conceptional age from smoking (n = 19) and non-smoking (n = 21) mothers. Assessment of tobacco exposure relied on maternal reports and newborns cotinine analysis. We observed how indicators of HRV depended on gestational age at birth. Results: At 33-34 weeks postconceptional age, the newborns from smoking mothers had lower HRV low frequency power normalised to the total spectral power (LF/TP) than the control group (median values: 8% vs. 15% respectively, p < 0.02). In the non-smoking group, RR-interval values and total HRV power were correlated with gestational age at birth, with a shorter RR and a lower total HRV power in lesser gestational ages (ρ = 0.67, p = 0.03, ρ = 0.71, p = 0.003 respectively). This correlation was not observed for RR values in the group with smoking mothers.

AB - Objective: Tobacco smoke exposure increases the risk of premature birth and of dying of sudden infant death syndrome (SIDS). Prematurity significantly increases the risk of dying of SIDS, but mechanisms underlying this epidemiological finding are unclear. The cumulated effect of both prematurity and prenatal exposure to nicotine on autonomic heart rate control has not been studied. Methods: Using coarse-graining spectral analysis, we compared heart rate variability (HRV) indices of preterm newborns at 33-34 weeks post-conceptional age from smoking (n = 19) and non-smoking (n = 21) mothers. Assessment of tobacco exposure relied on maternal reports and newborns cotinine analysis. We observed how indicators of HRV depended on gestational age at birth. Results: At 33-34 weeks postconceptional age, the newborns from smoking mothers had lower HRV low frequency power normalised to the total spectral power (LF/TP) than the control group (median values: 8% vs. 15% respectively, p < 0.02). In the non-smoking group, RR-interval values and total HRV power were correlated with gestational age at birth, with a shorter RR and a lower total HRV power in lesser gestational ages (ρ = 0.67, p = 0.03, ρ = 0.71, p = 0.003 respectively). This correlation was not observed for RR values in the group with smoking mothers.

KW - Autonomic nervous system

KW - Cigarette smoking

KW - Heart rate variability

KW - Premature infant

KW - Sudden infant death syndrome

UR - http://www.scopus.com/inward/record.url?scp=67649099343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649099343&partnerID=8YFLogxK

U2 - 10.1007/s10286-009-0003-8

DO - 10.1007/s10286-009-0003-8

M3 - Article

VL - 19

SP - 149

EP - 156

JO - Clinical Autonomic Research

JF - Clinical Autonomic Research

SN - 0959-9851

IS - 3

ER -