Abstract
Objective: Tobacco smoke exposure increases the risk of premature birth and of dying of sudden infant death syndrome (SIDS). Prematurity significantly increases the risk of dying of SIDS, but mechanisms underlying this epidemiological finding are unclear. The cumulated effect of both prematurity and prenatal exposure to nicotine on autonomic heart rate control has not been studied. Methods: Using coarse-graining spectral analysis, we compared heart rate variability (HRV) indices of preterm newborns at 33-34 weeks post-conceptional age from smoking (n = 19) and non-smoking (n = 21) mothers. Assessment of tobacco exposure relied on maternal reports and newborns cotinine analysis. We observed how indicators of HRV depended on gestational age at birth. Results: At 33-34 weeks postconceptional age, the newborns from smoking mothers had lower HRV low frequency power normalised to the total spectral power (LF/TP) than the control group (median values: 8% vs. 15% respectively, p < 0.02). In the non-smoking group, RR-interval values and total HRV power were correlated with gestational age at birth, with a shorter RR and a lower total HRV power in lesser gestational ages (ρ = 0.67, p = 0.03, ρ = 0.71, p = 0.003 respectively). This correlation was not observed for RR values in the group with smoking mothers.
| Original language | English |
|---|---|
| Pages (from-to) | 149-156 |
| Number of pages | 8 |
| Journal | Clinical Autonomic Research |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Jun 2009 |
| Externally published | Yes |
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Keywords
- Autonomic nervous system
- Cigarette smoking
- Heart rate variability
- Premature infant
- Sudden infant death syndrome
ASJC Scopus subject areas
- Clinical Neurology
- Endocrine and Autonomic Systems
Cite this
Heart rate variability in preterm infants and maternal smoking during pregnancy. / Thiriez, Gérard; Bouhaddi, Malika; Mourot, Laurent; Nobili, François; Fortrat, Jacques Olivier; Menget, Alain; Franco, Patricia; Regnard, Jacques.
In: Clinical Autonomic Research, Vol. 19, No. 3, 01.06.2009, p. 149-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heart rate variability in preterm infants and maternal smoking during pregnancy
AU - Thiriez, Gérard
AU - Bouhaddi, Malika
AU - Mourot, Laurent
AU - Nobili, François
AU - Fortrat, Jacques Olivier
AU - Menget, Alain
AU - Franco, Patricia
AU - Regnard, Jacques
PY - 2009/6/1
Y1 - 2009/6/1
N2 - Objective: Tobacco smoke exposure increases the risk of premature birth and of dying of sudden infant death syndrome (SIDS). Prematurity significantly increases the risk of dying of SIDS, but mechanisms underlying this epidemiological finding are unclear. The cumulated effect of both prematurity and prenatal exposure to nicotine on autonomic heart rate control has not been studied. Methods: Using coarse-graining spectral analysis, we compared heart rate variability (HRV) indices of preterm newborns at 33-34 weeks post-conceptional age from smoking (n = 19) and non-smoking (n = 21) mothers. Assessment of tobacco exposure relied on maternal reports and newborns cotinine analysis. We observed how indicators of HRV depended on gestational age at birth. Results: At 33-34 weeks postconceptional age, the newborns from smoking mothers had lower HRV low frequency power normalised to the total spectral power (LF/TP) than the control group (median values: 8% vs. 15% respectively, p < 0.02). In the non-smoking group, RR-interval values and total HRV power were correlated with gestational age at birth, with a shorter RR and a lower total HRV power in lesser gestational ages (ρ = 0.67, p = 0.03, ρ = 0.71, p = 0.003 respectively). This correlation was not observed for RR values in the group with smoking mothers.
AB - Objective: Tobacco smoke exposure increases the risk of premature birth and of dying of sudden infant death syndrome (SIDS). Prematurity significantly increases the risk of dying of SIDS, but mechanisms underlying this epidemiological finding are unclear. The cumulated effect of both prematurity and prenatal exposure to nicotine on autonomic heart rate control has not been studied. Methods: Using coarse-graining spectral analysis, we compared heart rate variability (HRV) indices of preterm newborns at 33-34 weeks post-conceptional age from smoking (n = 19) and non-smoking (n = 21) mothers. Assessment of tobacco exposure relied on maternal reports and newborns cotinine analysis. We observed how indicators of HRV depended on gestational age at birth. Results: At 33-34 weeks postconceptional age, the newborns from smoking mothers had lower HRV low frequency power normalised to the total spectral power (LF/TP) than the control group (median values: 8% vs. 15% respectively, p < 0.02). In the non-smoking group, RR-interval values and total HRV power were correlated with gestational age at birth, with a shorter RR and a lower total HRV power in lesser gestational ages (ρ = 0.67, p = 0.03, ρ = 0.71, p = 0.003 respectively). This correlation was not observed for RR values in the group with smoking mothers.
KW - Autonomic nervous system
KW - Cigarette smoking
KW - Heart rate variability
KW - Premature infant
KW - Sudden infant death syndrome
UR - http://www.scopus.com/inward/record.url?scp=67649099343&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649099343&partnerID=8YFLogxK
U2 - 10.1007/s10286-009-0003-8
DO - 10.1007/s10286-009-0003-8
M3 - Article
VL - 19
SP - 149
EP - 156
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
SN - 0959-9851
IS - 3
ER -