Halonal is a phenobarbital inductor of the monooxygenase system

A. S. Saratikov, T. P. Novozheeva, R. R. Akhmedzhanov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Experiments on rats demonstrated induction of the hepatic monooxygenase system with halonal. The effects of halonal and phenobarbital on the contents of cytochrome P-450 and its isoform P-450b+e and on the rate of substrate metabolism were similar. This suggests that enzyme-inducing activity of halonal is determined by the effect of its major metabolite. It cannot be excluded that halonal molecules possess intrinsic enzyme-inducing activity.

Original languageEnglish
Pages (from-to)264-266
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume134
Issue number3
DOIs
Publication statusPublished - 1 Sep 2002

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Keywords

  • Halonal
  • Liver
  • Monooxygenase system
  • Phenobarbital

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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