Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles: Synthesis and applications of 5-fluorotriazoles

Abstract

A good exchange: 5-Iodo-1,2,3-triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5-fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3-triazole compounds.

Original language	English
Pages (from-to)	11791-11794
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	47
DOIs	https://doi.org/10.1002/anie.201204979
Publication status	Published - 19 Nov 2012
Externally published	Yes

Keywords

click chemistry
fluorine
heterocycles
imaging agents
nucleophilic substitution

ASJC Scopus subject areas

Chemistry(all)
Catalysis

Access to Document

10.1002/anie.201204979

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abstract = "A good exchange: 5-Iodo-1,2,3-triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5-fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3-triazole compounds.",

keywords = "click chemistry, fluorine, heterocycles, imaging agents, nucleophilic substitution",

author = "Worrell, {Brady T.} and Hein, {Jason E.} and Fokin, {Valery V.}",

year = "2012",

month = nov,

day = "19",

doi = "10.1002/anie.201204979",

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T2 - Synthesis and applications of 5-fluorotriazoles

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AU - Hein, Jason E.

AU - Fokin, Valery V.

PY - 2012/11/19

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AB - A good exchange: 5-Iodo-1,2,3-triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5-fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3-triazole compounds.

KW - click chemistry

KW - fluorine

KW - heterocycles

KW - imaging agents

KW - nucleophilic substitution

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