Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles: Synthesis and applications of 5-fluorotriazoles

Brady T. Worrell, Jason E. Hein, Valery V. Fokin

Research output: Contribution to journal › Article

Abstract

A good exchange: 5-Iodo-1,2,3-triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5-fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3-triazole compounds.

Original language	English
Pages (from-to)	11791-11794
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	47
DOIs	https://doi.org/10.1002/anie.201204979
Publication status	Published - 19 Nov 2012
Externally published	Yes

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Keywords

click chemistry
fluorine
heterocycles
imaging agents
nucleophilic substitution

ASJC Scopus subject areas

Chemistry(all)
Catalysis

Cite this

Worrell, B. T., Hein, J. E., & Fokin, V. V. (2012). Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles: Synthesis and applications of 5-fluorotriazoles. Angewandte Chemie - International Edition, 51(47), 11791-11794. https://doi.org/10.1002/anie.201204979

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Access to Document

10.1002/anie.201204979