Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles: Synthesis and applications of 5-fluorotriazoles

Brady T. Worrell, Jason E. Hein, Valery V. Fokin

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

A good exchange: 5-Iodo-1,2,3-triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5-fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3-triazole compounds.

Original languageEnglish
Pages (from-to)11791-11794
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number47
DOIs
Publication statusPublished - 19 Nov 2012
Externally publishedYes

Fingerprint

Nucleophiles
Halogens
Triazoles
Fluorides
Ion exchange
Substitution reactions
Salts
5-iodo-1,2,3-triazole

Keywords

  • click chemistry
  • fluorine
  • heterocycles
  • imaging agents
  • nucleophilic substitution

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles : Synthesis and applications of 5-fluorotriazoles. / Worrell, Brady T.; Hein, Jason E.; Fokin, Valery V.

In: Angewandte Chemie - International Edition, Vol. 51, No. 47, 19.11.2012, p. 11791-11794.

Research output: Contribution to journalArticle

Worrell, Brady T. ; Hein, Jason E. ; Fokin, Valery V. / Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles : Synthesis and applications of 5-fluorotriazoles. In: Angewandte Chemie - International Edition. 2012 ; Vol. 51, No. 47. pp. 11791-11794.
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