Abstract
A good exchange: 5-Iodo-1,2,3-triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5-fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3-triazole compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 11791-11794 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 47 |
| DOIs | |
| Publication status | Published - 19 Nov 2012 |
| Externally published | Yes |
Keywords
- click chemistry
- fluorine
- heterocycles
- imaging agents
- nucleophilic substitution
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
Fingerprint Dive into the research topics of 'Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles: Synthesis and applications of 5-fluorotriazoles'. Together they form a unique fingerprint.
Cite this
Worrell, B. T., Hein, J. E., & Fokin, V. V. (2012). Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles: Synthesis and applications of 5-fluorotriazoles. Angewandte Chemie - International Edition, 51(47), 11791-11794. https://doi.org/10.1002/anie.201204979