Abstract
A good exchange: 5-Iodo-1,2,3-triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5-fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3-triazole compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 11791-11794 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 47 |
| DOIs | |
| Publication status | Published - 19 Nov 2012 |
| Externally published | Yes |
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Keywords
- click chemistry
- fluorine
- heterocycles
- imaging agents
- nucleophilic substitution
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
Cite this
Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles : Synthesis and applications of 5-fluorotriazoles. / Worrell, Brady T.; Hein, Jason E.; Fokin, Valery V.
In: Angewandte Chemie - International Edition, Vol. 51, No. 47, 19.11.2012, p. 11791-11794.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles
T2 - Synthesis and applications of 5-fluorotriazoles
AU - Worrell, Brady T.
AU - Hein, Jason E.
AU - Fokin, Valery V.
PY - 2012/11/19
Y1 - 2012/11/19
N2 - A good exchange: 5-Iodo-1,2,3-triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5-fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3-triazole compounds.
AB - A good exchange: 5-Iodo-1,2,3-triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5-fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3-triazole compounds.
KW - click chemistry
KW - fluorine
KW - heterocycles
KW - imaging agents
KW - nucleophilic substitution
UR - http://www.scopus.com/inward/record.url?scp=84869396350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869396350&partnerID=8YFLogxK
U2 - 10.1002/anie.201204979
DO - 10.1002/anie.201204979
M3 - Article
C2 - 23059856
AN - SCOPUS:84869396350
VL - 51
SP - 11791
EP - 11794
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 47
ER -