Gas chromatography analysis of ketamine on chelate containing phases

Yu G. Slizhov, M. A. Gavrilenko, T. N. Matveeva, P. A. Mizin

Research output: Contribution to journalArticle

Abstract

It is well known that ketamine is a medicinal drug having narcotic action and which has several tautomeric forms. For gas chromatography determination of keto- and enol forms of ketamine phases based on polymethylsiloxane elastomer with nickel dimethylglyoximate and nickel, europium and honeys acetylacetonates are used. Evaluation of the chromatographic conditions criteria on the separations was performed. The influence of different solvents (water, ethanol, acetone, ethylacetate, hexane and others) on the ratio of the isomeric forms of ketamine and the balance constant were studied. Results show a good correlation with data obtained by spectroscopy. The purity of the studied pharmaceuticals according to HPLC was 99,8%.

Original languageEnglish
Pages (from-to)251
Number of pages1
JournalJournal de Pharmacie de Belgique
Volume53
Issue number3
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Pharmaceutical Science

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