Abstract
A reaction sequence consisting of the “Diacetylene zipper” of buta-1,3-diynes from internal to terminal isomers, followed by Sonogashira cross-coupling with 3-,4- or 5-iodopyrazoles, was investigated as a new approach to buta-1,3-diynyl-N-methylpyrazoles. Various pyrazoles bearing alkyl and hydroxyalkyl containing buta-1,3-diyne substituents in the 3-,4- or 5-position and functional groups at the neighboring positions of the ring were obtained.
| Original language | English |
|---|---|
| Pages (from-to) | 762-765 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 58 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1 Jan 2017 |
| Externally published | Yes |
Keywords
- Buta-1,3-diynes
- Diacetylene zipper
- Pyrazoles
- Sonogashira cross-coupling
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Govdi, A. I., Kulyashova, A. E., Vasilevsky, S. F., & Balova, I. A. (2017). Functionalized buta-1,3-diynyl-N-methylpyrazoles by sequential “diacetylene zipper” and Sonogashira coupling reactions. Tetrahedron Letters, 58(8), 762-765. https://doi.org/10.1016/j.tetlet.2017.01.032