Abstract
A reaction sequence consisting of the “Diacetylene zipper” of buta-1,3-diynes from internal to terminal isomers, followed by Sonogashira cross-coupling with 3-,4- or 5-iodopyrazoles, was investigated as a new approach to buta-1,3-diynyl-N-methylpyrazoles. Various pyrazoles bearing alkyl and hydroxyalkyl containing buta-1,3-diyne substituents in the 3-,4- or 5-position and functional groups at the neighboring positions of the ring were obtained.
| Original language | English |
|---|---|
| Pages (from-to) | 762-765 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 58 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1 Jan 2017 |
| Externally published | Yes |
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Keywords
- Buta-1,3-diynes
- Diacetylene zipper
- Pyrazoles
- Sonogashira cross-coupling
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
Cite this
Functionalized buta-1,3-diynyl-N-methylpyrazoles by sequential “diacetylene zipper” and Sonogashira coupling reactions. / Govdi, Anastasiya I.; Kulyashova, Alexandra E.; Vasilevsky, Sergey F.; Balova, Irina A.
In: Tetrahedron Letters, Vol. 58, No. 8, 01.01.2017, p. 762-765.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Functionalized buta-1,3-diynyl-N-methylpyrazoles by sequential “diacetylene zipper” and Sonogashira coupling reactions
AU - Govdi, Anastasiya I.
AU - Kulyashova, Alexandra E.
AU - Vasilevsky, Sergey F.
AU - Balova, Irina A.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - A reaction sequence consisting of the “Diacetylene zipper” of buta-1,3-diynes from internal to terminal isomers, followed by Sonogashira cross-coupling with 3-,4- or 5-iodopyrazoles, was investigated as a new approach to buta-1,3-diynyl-N-methylpyrazoles. Various pyrazoles bearing alkyl and hydroxyalkyl containing buta-1,3-diyne substituents in the 3-,4- or 5-position and functional groups at the neighboring positions of the ring were obtained.
AB - A reaction sequence consisting of the “Diacetylene zipper” of buta-1,3-diynes from internal to terminal isomers, followed by Sonogashira cross-coupling with 3-,4- or 5-iodopyrazoles, was investigated as a new approach to buta-1,3-diynyl-N-methylpyrazoles. Various pyrazoles bearing alkyl and hydroxyalkyl containing buta-1,3-diyne substituents in the 3-,4- or 5-position and functional groups at the neighboring positions of the ring were obtained.
KW - Buta-1,3-diynes
KW - Diacetylene zipper
KW - Pyrazoles
KW - Sonogashira cross-coupling
UR - http://www.scopus.com/inward/record.url?scp=85009796972&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009796972&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2017.01.032
DO - 10.1016/j.tetlet.2017.01.032
M3 - Article
VL - 58
SP - 762
EP - 765
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 8
ER -