Functionalized buta-1,3-diynyl-N-methylpyrazoles by sequential “diacetylene zipper” and Sonogashira coupling reactions

Anastasiya I. Govdi, Alexandra E. Kulyashova, Sergey F. Vasilevsky, Irina A. Balova

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A reaction sequence consisting of the “Diacetylene zipper” of buta-1,3-diynes from internal to terminal isomers, followed by Sonogashira cross-coupling with 3-,4- or 5-iodopyrazoles, was investigated as a new approach to buta-1,3-diynyl-N-methylpyrazoles. Various pyrazoles bearing alkyl and hydroxyalkyl containing buta-1,3-diyne substituents in the 3-,4- or 5-position and functional groups at the neighboring positions of the ring were obtained.

Original languageEnglish
Pages (from-to)762-765
Number of pages4
JournalTetrahedron Letters
Volume58
Issue number8
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Keywords

  • Buta-1,3-diynes
  • Diacetylene zipper
  • Pyrazoles
  • Sonogashira cross-coupling

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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