Abstract
Parameters of respiration, transmembrane potential, and Ca 2+-binding capacity of mitochondria isolated from Langendorff-perfused hearts of rats adapted to normobaric hypoxia were analyzed. Ischemia and reperfusion modeling in intact and adapted animals reduced Ca 2+-binding capacity of mitochondria, which indicated increased sensitivity of mitochondrial permeability transition pores (MPTP) to calcium ions. These changes were accompanied by a decrease in transmembrane potential, ADP/O coeffi cient (ratio of added ADP to oxygen consumption in State 3), and inhibition of State 3 respiration. At the same time, adaptation attenuated the negative effect of ischemia and reperfusion on the functional state of mitochondria.
| Original language | English |
|---|---|
| Pages (from-to) | 645-648 |
| Number of pages | 4 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 156 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 Jan 2014 |
Keywords
- adaptation to hypoxia
- heart
- ischemia
- mitochondria
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Lishmanov, Y. B., Naryzhnaya, N. V., Maslov, L. N., Prokudina, E. S., Gorbunov, A. S., & Tsibulnikov, S. Y. (2014). Functional state of myocardial mitochondria in ischemia reperfusion of the heart in rats adapted to hypoxia. Bulletin of Experimental Biology and Medicine, 156(5), 645-648. https://doi.org/10.1007/s10517-014-2416-1