Functional state of myocardial mitochondria in ischemia reperfusion of the heart in rats adapted to hypoxia

Yu B. Lishmanov, N. V. Naryzhnaya, L. N. Maslov, E. S. Prokudina, A. S. Gorbunov, S. Yu Tsibulnikov

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Abstract

Parameters of respiration, transmembrane potential, and Ca 2+-binding capacity of mitochondria isolated from Langendorff-perfused hearts of rats adapted to normobaric hypoxia were analyzed. Ischemia and reperfusion modeling in intact and adapted animals reduced Ca 2+-binding capacity of mitochondria, which indicated increased sensitivity of mitochondrial permeability transition pores (MPTP) to calcium ions. These changes were accompanied by a decrease in transmembrane potential, ADP/O coeffi cient (ratio of added ADP to oxygen consumption in State 3), and inhibition of State 3 respiration. At the same time, adaptation attenuated the negative effect of ischemia and reperfusion on the functional state of mitochondria.

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume156
Issue number5
DOIs
Publication statusPublished - 1 Jan 2014

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Keywords

  • adaptation to hypoxia
  • heart
  • ischemia
  • mitochondria

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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