Abstract
Parameters of respiration, transmembrane potential, and Ca 2+-binding capacity of mitochondria isolated from Langendorff-perfused hearts of rats adapted to normobaric hypoxia were analyzed. Ischemia and reperfusion modeling in intact and adapted animals reduced Ca 2+-binding capacity of mitochondria, which indicated increased sensitivity of mitochondrial permeability transition pores (MPTP) to calcium ions. These changes were accompanied by a decrease in transmembrane potential, ADP/O coeffi cient (ratio of added ADP to oxygen consumption in State 3), and inhibition of State 3 respiration. At the same time, adaptation attenuated the negative effect of ischemia and reperfusion on the functional state of mitochondria.
Original language | English |
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Pages (from-to) | 645-648 |
Number of pages | 4 |
Journal | Bulletin of Experimental Biology and Medicine |
Volume | 156 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Jan 2014 |
Keywords
- adaptation to hypoxia
- heart
- ischemia
- mitochondria
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)