Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®

Natalia S. Soldatova, Pavel S. Postnikov, Mekhman S. Yusubov, Thomas Wirth

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.

Original languageEnglish
JournalEuropean Journal of Organic Chemistry
DOIs
Publication statusPublished - 1 Jan 2019

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Trifluoroacetic Acid
Organic compounds
Salts
cartridges
Oxidation
oxidation
synthesis
organic compounds
reactors
methodology
chemistry
salts
preparation
optimization
potassium peroxymonosulfuric acid

Keywords

  • Continuous flow
  • Iodonium salts
  • Nelder–Mead method
  • Oxidation
  • Oxone

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®. / Soldatova, Natalia S.; Postnikov, Pavel S.; Yusubov, Mekhman S.; Wirth, Thomas.

In: European Journal of Organic Chemistry, 01.01.2019.

Research output: Contribution to journal › Article

Soldatova, NS, Postnikov, PS, Yusubov, MS & Wirth, T 2019, 'Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®', European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.201900220
Soldatova NS, Postnikov PS, Yusubov MS, Wirth T. Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®. European Journal of Organic Chemistry. 2019 Jan 1. https://doi.org/10.1002/ejoc.201900220
Soldatova, Natalia S. ; Postnikov, Pavel S. ; Yusubov, Mekhman S. ; Wirth, Thomas. / Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®. In: European Journal of Organic Chemistry. 2019.
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