Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®

Natalia S. Soldatova, Pavel S. Postnikov, Mekhman S. Yusubov, Thomas Wirth

Research School of Chemistry & Applied Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.

Original language	English
Journal	European Journal of Organic Chemistry
DOIs	https://doi.org/10.1002/ejoc.201900220
Publication status	Published - 1 Jan 2019

Keywords

Continuous flow
Iodonium salts
Nelder–Mead method
Oxidation
Oxone

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1002/ejoc.201900220

Fingerprint Dive into the research topics of 'Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®'. Together they form a unique fingerprint.

Cite this

@article{26729f5619bf4f839f252f4723a77e42,

title = "Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone{\textregistered}",

abstract = "Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.",

keywords = "Continuous flow, Iodonium salts, Nelder–Mead method, Oxidation, Oxone",

author = "Soldatova, {Natalia S.} and Postnikov, {Pavel S.} and Yusubov, {Mekhman S.} and Thomas Wirth",

year = "2019",

month = jan,

day = "1",

doi = "10.1002/ejoc.201900220",

language = "English",

journal = "Annalen der Pharmacie",

issn = "0075-4617",

publisher = "Wiley-VCH Verlag",

}

TY - JOUR

T1 - Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®

AU - Soldatova, Natalia S.

AU - Postnikov, Pavel S.

AU - Yusubov, Mekhman S.

AU - Wirth, Thomas

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.

AB - Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.

KW - Continuous flow

KW - Iodonium salts

KW - Nelder–Mead method

KW - Oxidation

KW - Oxone

UR - http://www.scopus.com/inward/record.url?scp=85062572987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062572987&partnerID=8YFLogxK

U2 - 10.1002/ejoc.201900220

DO - 10.1002/ejoc.201900220

M3 - Article

AN - SCOPUS:85062572987

JO - Annalen der Pharmacie

JF - Annalen der Pharmacie

SN - 0075-4617

ER -