Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®

Abstract

Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.

Original language	English
Journal	European Journal of Organic Chemistry
DOIs	https://doi.org/10.1002/ejoc.201900220
Publication status	Published - 1 Jan 2019

Keywords

Continuous flow
Iodonium salts
Nelder–Mead method
Oxidation
Oxone

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1002/ejoc.201900220

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Soldatova, N. S., Postnikov, P. S., Yusubov, M. S., & Wirth, T. (2019). Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®. European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.201900220

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author = "Soldatova, {Natalia S.} and Postnikov, {Pavel S.} and Yusubov, {Mekhman S.} and Thomas Wirth",

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AU - Wirth, Thomas

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