Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®

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Abstract

Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.

Original languageEnglish
JournalEuropean Journal of Organic Chemistry
DOIs
Publication statusPublished - 1 Jan 2019

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Keywords

  • Continuous flow
  • Iodonium salts
  • Nelder–Mead method
  • Oxidation
  • Oxone

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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