Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®

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1 Citation (Scopus)

Abstract

Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.

Original languageEnglish
JournalEuropean Journal of Organic Chemistry
DOIs
Publication statusPublished - 1 Jan 2019

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Trifluoroacetic Acid
Organic compounds
Salts
cartridges
Oxidation
oxidation
synthesis
organic compounds
reactors
methodology
chemistry
salts
preparation
optimization
potassium peroxymonosulfuric acid

Keywords

  • Continuous flow
  • Iodonium salts
  • Nelder–Mead method
  • Oxidation
  • Oxone

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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abstract = "Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.",
keywords = "Continuous flow, Iodonium salts, Nelder–Mead method, Oxidation, Oxone",
author = "Soldatova, {Natalia S.} and Postnikov, {Pavel S.} and Yusubov, {Mekhman S.} and Thomas Wirth",
year = "2019",
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doi = "10.1002/ejoc.201900220",
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AU - Soldatova, Natalia S.

AU - Postnikov, Pavel S.

AU - Yusubov, Mekhman S.

AU - Wirth, Thomas

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.

AB - Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.

KW - Continuous flow

KW - Iodonium salts

KW - Nelder–Mead method

KW - Oxidation

KW - Oxone

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