Abstract
Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone-filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.
Original language | English |
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Journal | European Journal of Organic Chemistry |
DOIs | |
Publication status | Published - 1 Jan 2019 |
Keywords
- Continuous flow
- Iodonium salts
- Nelder–Mead method
- Oxidation
- Oxone
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry