Abstract
A solution blow spinning technique is a method developed recently for making nonwoven webs of micro- and nanofibres. The principal advantage of this method compared to a more traditional electrospinning process is its significantly higher production rate. In this work, the solution blow spinning method was further developed to produce nonwoven polymeric scaffolds based on a copolymer of tetrafluoroethylene with vinylidene fluoride solution in acetone. A crucial feature of the proposed method is that high-voltage equipment is not required, which further improves the method's economics. Scanning electron microscopy analysis of the samples demonstrated that the surface morphology of the nonwoven materials is dependent on the polymer concentration in the spinning solution. It was concluded that an optimum morphology of the nonwoven scaffolds for medical applications is achieved by using a 5% solution of the copolymer. It was established that the scaffolds produced from the 5% solution have a fractal structure and anisotropic mechanical properties. X-ray diffraction, infrared spectroscopy, Raman spectroscopy and differential scanning calorimetry demonstrated that the fabricated nonwoven materials have crystal structures that exhibit ferroelectric properties. Gas chromatography has shown that the amount of acetone in the nonwoven material does not exceed the maximum allowable concentration of 0.5%. In vitro analysis, using the culture of motile cells, confirmed that the nonwoven material is non-toxic and does not alter the morpho-functional status of stem cells for short-term cultivation, and therefore can potentially be used in medical applications.
| Original language | English |
|---|---|
| Pages (from-to) | 32-41 |
| Number of pages | 10 |
| Journal | Materials Science and Engineering C |
| Volume | 40 |
| DOIs | |
| Publication status | Published - 1 Jul 2014 |
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Keywords
- Cytotoxicity
- Human stromal cells
- Morpho-functional status
- Polymeric ferroelectrics
- Scaffolds
- Solution blow spinning
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
- Mechanical Engineering
- Mechanics of Materials
- Medicine(all)
Cite this
Ferroelectric polymer scaffolds based on a copolymer of tetrafluoroethylene with vinylidene fluoride : Fabrication and properties. / Bolbasov, Evgeny Nikolaevich; Anissimov, Y. G.; Pustovoytov, A. V.; Khlusov, I. A.; Zaitsev, A. A.; Zaitsev, K. V.; Lapin, I. N.; Tverdokhlebov, S. I.
In: Materials Science and Engineering C, Vol. 40, 01.07.2014, p. 32-41.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ferroelectric polymer scaffolds based on a copolymer of tetrafluoroethylene with vinylidene fluoride
T2 - Fabrication and properties
AU - Bolbasov, Evgeny Nikolaevich
AU - Anissimov, Y. G.
AU - Pustovoytov, A. V.
AU - Khlusov, I. A.
AU - Zaitsev, A. A.
AU - Zaitsev, K. V.
AU - Lapin, I. N.
AU - Tverdokhlebov, S. I.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - A solution blow spinning technique is a method developed recently for making nonwoven webs of micro- and nanofibres. The principal advantage of this method compared to a more traditional electrospinning process is its significantly higher production rate. In this work, the solution blow spinning method was further developed to produce nonwoven polymeric scaffolds based on a copolymer of tetrafluoroethylene with vinylidene fluoride solution in acetone. A crucial feature of the proposed method is that high-voltage equipment is not required, which further improves the method's economics. Scanning electron microscopy analysis of the samples demonstrated that the surface morphology of the nonwoven materials is dependent on the polymer concentration in the spinning solution. It was concluded that an optimum morphology of the nonwoven scaffolds for medical applications is achieved by using a 5% solution of the copolymer. It was established that the scaffolds produced from the 5% solution have a fractal structure and anisotropic mechanical properties. X-ray diffraction, infrared spectroscopy, Raman spectroscopy and differential scanning calorimetry demonstrated that the fabricated nonwoven materials have crystal structures that exhibit ferroelectric properties. Gas chromatography has shown that the amount of acetone in the nonwoven material does not exceed the maximum allowable concentration of 0.5%. In vitro analysis, using the culture of motile cells, confirmed that the nonwoven material is non-toxic and does not alter the morpho-functional status of stem cells for short-term cultivation, and therefore can potentially be used in medical applications.
AB - A solution blow spinning technique is a method developed recently for making nonwoven webs of micro- and nanofibres. The principal advantage of this method compared to a more traditional electrospinning process is its significantly higher production rate. In this work, the solution blow spinning method was further developed to produce nonwoven polymeric scaffolds based on a copolymer of tetrafluoroethylene with vinylidene fluoride solution in acetone. A crucial feature of the proposed method is that high-voltage equipment is not required, which further improves the method's economics. Scanning electron microscopy analysis of the samples demonstrated that the surface morphology of the nonwoven materials is dependent on the polymer concentration in the spinning solution. It was concluded that an optimum morphology of the nonwoven scaffolds for medical applications is achieved by using a 5% solution of the copolymer. It was established that the scaffolds produced from the 5% solution have a fractal structure and anisotropic mechanical properties. X-ray diffraction, infrared spectroscopy, Raman spectroscopy and differential scanning calorimetry demonstrated that the fabricated nonwoven materials have crystal structures that exhibit ferroelectric properties. Gas chromatography has shown that the amount of acetone in the nonwoven material does not exceed the maximum allowable concentration of 0.5%. In vitro analysis, using the culture of motile cells, confirmed that the nonwoven material is non-toxic and does not alter the morpho-functional status of stem cells for short-term cultivation, and therefore can potentially be used in medical applications.
KW - Cytotoxicity
KW - Human stromal cells
KW - Morpho-functional status
KW - Polymeric ferroelectrics
KW - Scaffolds
KW - Solution blow spinning
UR - http://www.scopus.com/inward/record.url?scp=84898413687&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898413687&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2014.03.038
DO - 10.1016/j.msec.2014.03.038
M3 - Article
VL - 40
SP - 32
EP - 41
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
SN - 0928-4931
ER -