Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

Georgy Mikhaylov, Ursa Mikac, Anna A. Magaeva, Volya I. Itin, Evgeniy P. Naiden, Ivan Psakhye, Liane Babes, Thomas Reinheckel, Christoph Peters, Robert Zeiser, Matthew Bogyo, Vito Turk, Sergey G. Psakhye, Boris Turk, Olga Vasiljeva

Research output: Contribution to journalArticle

256 Citations (Scopus)

Abstract

The tumour microenvironment regulates tumour progression and the spread of cancer in the body. Targeting the stromal cells that surround cancer cells could, therefore, improve the effectiveness of existing cancer treatments. Here, we show that magnetic nanoparticle clusters encapsulated inside a liposome can, under the influence of an external magnet, target both the tumour and its microenvironment. We use the outstanding T 2 contrast properties (r 2 = 573-1,286s -1 mM -1) of these ferri-liposomes, which are ∼95nm in diameter, to non-invasively monitor drug delivery in vivo. We also visualize the targeting of the tumour microenvironment by the drug-loaded ferri-liposomes and the uptake of a model probe by cells. Furthermore, we used the ferri-liposomes to deliver a cathepsin protease inhibitor to a mammary tumour and its microenvironment in a mouse, which substantially reduced the size of the tumour compared with systemic delivery of the same drug.

Original languageEnglish
Pages (from-to)594-602
Number of pages9
JournalNature Nanotechnology
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Liposomes
Magnetic resonance imaging
Tumors
delivery
drugs
tumors
cancer
Cathepsins
protease
Oncology
Protease Inhibitors
Drug delivery
progressions
Pharmaceutical Preparations
inhibitors
Magnets
mice
Drug Delivery Systems
monitors
magnets

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Electrical and Electronic Engineering
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics

Cite this

Mikhaylov, G., Mikac, U., Magaeva, A. A., Itin, V. I., Naiden, E. P., Psakhye, I., ... Vasiljeva, O. (2011). Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nature Nanotechnology, 6(9), 594-602. https://doi.org/10.1038/nnano.2011.112

Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. / Mikhaylov, Georgy; Mikac, Ursa; Magaeva, Anna A.; Itin, Volya I.; Naiden, Evgeniy P.; Psakhye, Ivan; Babes, Liane; Reinheckel, Thomas; Peters, Christoph; Zeiser, Robert; Bogyo, Matthew; Turk, Vito; Psakhye, Sergey G.; Turk, Boris; Vasiljeva, Olga.

In: Nature Nanotechnology, Vol. 6, No. 9, 09.2011, p. 594-602.

Research output: Contribution to journalArticle

Mikhaylov, G, Mikac, U, Magaeva, AA, Itin, VI, Naiden, EP, Psakhye, I, Babes, L, Reinheckel, T, Peters, C, Zeiser, R, Bogyo, M, Turk, V, Psakhye, SG, Turk, B & Vasiljeva, O 2011, 'Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment', Nature Nanotechnology, vol. 6, no. 9, pp. 594-602. https://doi.org/10.1038/nnano.2011.112
Mikhaylov, Georgy ; Mikac, Ursa ; Magaeva, Anna A. ; Itin, Volya I. ; Naiden, Evgeniy P. ; Psakhye, Ivan ; Babes, Liane ; Reinheckel, Thomas ; Peters, Christoph ; Zeiser, Robert ; Bogyo, Matthew ; Turk, Vito ; Psakhye, Sergey G. ; Turk, Boris ; Vasiljeva, Olga. / Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. In: Nature Nanotechnology. 2011 ; Vol. 6, No. 9. pp. 594-602.
@article{afb7118f1ad74dba9a6311154caf818d,
title = "Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment",
abstract = "The tumour microenvironment regulates tumour progression and the spread of cancer in the body. Targeting the stromal cells that surround cancer cells could, therefore, improve the effectiveness of existing cancer treatments. Here, we show that magnetic nanoparticle clusters encapsulated inside a liposome can, under the influence of an external magnet, target both the tumour and its microenvironment. We use the outstanding T 2 contrast properties (r 2 = 573-1,286s -1 mM -1) of these ferri-liposomes, which are ∼95nm in diameter, to non-invasively monitor drug delivery in vivo. We also visualize the targeting of the tumour microenvironment by the drug-loaded ferri-liposomes and the uptake of a model probe by cells. Furthermore, we used the ferri-liposomes to deliver a cathepsin protease inhibitor to a mammary tumour and its microenvironment in a mouse, which substantially reduced the size of the tumour compared with systemic delivery of the same drug.",
author = "Georgy Mikhaylov and Ursa Mikac and Magaeva, {Anna A.} and Itin, {Volya I.} and Naiden, {Evgeniy P.} and Ivan Psakhye and Liane Babes and Thomas Reinheckel and Christoph Peters and Robert Zeiser and Matthew Bogyo and Vito Turk and Psakhye, {Sergey G.} and Boris Turk and Olga Vasiljeva",
year = "2011",
month = "9",
doi = "10.1038/nnano.2011.112",
language = "English",
volume = "6",
pages = "594--602",
journal = "Nature Nanotechnology",
issn = "1748-3387",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

AU - Mikhaylov, Georgy

AU - Mikac, Ursa

AU - Magaeva, Anna A.

AU - Itin, Volya I.

AU - Naiden, Evgeniy P.

AU - Psakhye, Ivan

AU - Babes, Liane

AU - Reinheckel, Thomas

AU - Peters, Christoph

AU - Zeiser, Robert

AU - Bogyo, Matthew

AU - Turk, Vito

AU - Psakhye, Sergey G.

AU - Turk, Boris

AU - Vasiljeva, Olga

PY - 2011/9

Y1 - 2011/9

N2 - The tumour microenvironment regulates tumour progression and the spread of cancer in the body. Targeting the stromal cells that surround cancer cells could, therefore, improve the effectiveness of existing cancer treatments. Here, we show that magnetic nanoparticle clusters encapsulated inside a liposome can, under the influence of an external magnet, target both the tumour and its microenvironment. We use the outstanding T 2 contrast properties (r 2 = 573-1,286s -1 mM -1) of these ferri-liposomes, which are ∼95nm in diameter, to non-invasively monitor drug delivery in vivo. We also visualize the targeting of the tumour microenvironment by the drug-loaded ferri-liposomes and the uptake of a model probe by cells. Furthermore, we used the ferri-liposomes to deliver a cathepsin protease inhibitor to a mammary tumour and its microenvironment in a mouse, which substantially reduced the size of the tumour compared with systemic delivery of the same drug.

AB - The tumour microenvironment regulates tumour progression and the spread of cancer in the body. Targeting the stromal cells that surround cancer cells could, therefore, improve the effectiveness of existing cancer treatments. Here, we show that magnetic nanoparticle clusters encapsulated inside a liposome can, under the influence of an external magnet, target both the tumour and its microenvironment. We use the outstanding T 2 contrast properties (r 2 = 573-1,286s -1 mM -1) of these ferri-liposomes, which are ∼95nm in diameter, to non-invasively monitor drug delivery in vivo. We also visualize the targeting of the tumour microenvironment by the drug-loaded ferri-liposomes and the uptake of a model probe by cells. Furthermore, we used the ferri-liposomes to deliver a cathepsin protease inhibitor to a mammary tumour and its microenvironment in a mouse, which substantially reduced the size of the tumour compared with systemic delivery of the same drug.

UR - http://www.scopus.com/inward/record.url?scp=80052587306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052587306&partnerID=8YFLogxK

U2 - 10.1038/nnano.2011.112

DO - 10.1038/nnano.2011.112

M3 - Article

C2 - 21822252

AN - SCOPUS:80052587306

VL - 6

SP - 594

EP - 602

JO - Nature Nanotechnology

JF - Nature Nanotechnology

SN - 1748-3387

IS - 9

ER -