Feasibility of isotopic exchange in the system [125I] iodide-undecahydro-iodo-closo-dodecaborate(2-) anion

M. V. Korsakov, E. V. Shchukin, L. N. Korsakova, A. M. Orlova, S. Sjöberg, V. Tolmachev

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Derivatives of the closo-dodecaborate dianion are routinely used or proposed for use in boron neutron capture therapy of cancer. The use of radioactive label on closo-dodecaborate might facilitate pharmacokinetic studies. The use of nucleophilic reactions might be of advantage if derivatives of closo-dodecaborate were oxidation sensitive. The aim of this study was to estimate the feasibility of isotopic exchange in radioiodide - iodo-undecahydro-closo-dodecaborate system. We demonstrated that copper-catalyzed isotope exchange in this system in molten acetamide provides a labeling yield of 78.4±1.1% after 30 minutes at 170 °C. The influence of the ratio between amounts of substrate and catalyst, temperature and time on the labeling yield was studied.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume256
Issue number1
DOIs
Publication statusPublished - 1 Apr 2003
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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