Feasibility of isotopic exchange in the system [<sup>125</sup>I] iodide-undecahydro-iodo-closo-dodecaborate(2-) anion

Abstract

Derivatives of the closo-dodecaborate dianion are routinely used or proposed for use in boron neutron capture therapy of cancer. The use of radioactive label on closo-dodecaborate might facilitate pharmacokinetic studies. The use of nucleophilic reactions might be of advantage if derivatives of closo-dodecaborate were oxidation sensitive. The aim of this study was to estimate the feasibility of isotopic exchange in radioiodide - iodo-undecahydro-closo-dodecaborate system. We demonstrated that copper-catalyzed isotope exchange in this system in molten acetamide provides a labeling yield of 78.4±1.1% after 30 minutes at 170 °C. The influence of the ratio between amounts of substrate and catalyst, temperature and time on the labeling yield was studied.

Original language	English
Pages (from-to)	67-71
Number of pages	5
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	256
Issue number	1
DOIs	https://doi.org/10.1023/A:1023348025353
Publication status	Published - 1 Apr 2003
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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@article{729ac814da014d259674ee73ae2b5ff5,

title = "Feasibility of isotopic exchange in the system [125I] iodide-undecahydro-iodo-closo-dodecaborate(2-) anion",

abstract = "Derivatives of the closo-dodecaborate dianion are routinely used or proposed for use in boron neutron capture therapy of cancer. The use of radioactive label on closo-dodecaborate might facilitate pharmacokinetic studies. The use of nucleophilic reactions might be of advantage if derivatives of closo-dodecaborate were oxidation sensitive. The aim of this study was to estimate the feasibility of isotopic exchange in radioiodide - iodo-undecahydro-closo-dodecaborate system. We demonstrated that copper-catalyzed isotope exchange in this system in molten acetamide provides a labeling yield of 78.4±1.1% after 30 minutes at 170 °C. The influence of the ratio between amounts of substrate and catalyst, temperature and time on the labeling yield was studied.",

author = "Korsakov, {M. V.} and Shchukin, {E. V.} and Korsakova, {L. N.} and Orlova, {A. M.} and S. Sj{\"o}berg and V. Tolmachev",

note = "Funding Information: This work was supported by grants from Swedish Cancer Society, Swedish Royal Academy of Sciences and INTAS. Copyright: Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.",

year = "2003",

month = apr,

day = "1",

doi = "10.1023/A:1023348025353",

language = "English",

volume = "256",

pages = "67--71",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

issn = "0236-5731",

publisher = "Elsevier BV",

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}

TY - JOUR

T1 - Feasibility of isotopic exchange in the system [125I] iodide-undecahydro-iodo-closo-dodecaborate(2-) anion

AU - Korsakov, M. V.

AU - Shchukin, E. V.

AU - Korsakova, L. N.

AU - Orlova, A. M.

AU - Sjöberg, S.

AU - Tolmachev, V.

N1 - Funding Information: This work was supported by grants from Swedish Cancer Society, Swedish Royal Academy of Sciences and INTAS. Copyright: Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Derivatives of the closo-dodecaborate dianion are routinely used or proposed for use in boron neutron capture therapy of cancer. The use of radioactive label on closo-dodecaborate might facilitate pharmacokinetic studies. The use of nucleophilic reactions might be of advantage if derivatives of closo-dodecaborate were oxidation sensitive. The aim of this study was to estimate the feasibility of isotopic exchange in radioiodide - iodo-undecahydro-closo-dodecaborate system. We demonstrated that copper-catalyzed isotope exchange in this system in molten acetamide provides a labeling yield of 78.4±1.1% after 30 minutes at 170 °C. The influence of the ratio between amounts of substrate and catalyst, temperature and time on the labeling yield was studied.

AB - Derivatives of the closo-dodecaborate dianion are routinely used or proposed for use in boron neutron capture therapy of cancer. The use of radioactive label on closo-dodecaborate might facilitate pharmacokinetic studies. The use of nucleophilic reactions might be of advantage if derivatives of closo-dodecaborate were oxidation sensitive. The aim of this study was to estimate the feasibility of isotopic exchange in radioiodide - iodo-undecahydro-closo-dodecaborate system. We demonstrated that copper-catalyzed isotope exchange in this system in molten acetamide provides a labeling yield of 78.4±1.1% after 30 minutes at 170 °C. The influence of the ratio between amounts of substrate and catalyst, temperature and time on the labeling yield was studied.

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