Far-red fluorescent cell line for preclinical study of HER2-targeted agents

I. V. Balalaeva, E. A. Sokolova, A. A. Brilkina, S. M. Deyev, R. V. Petrov

Research output: Contribution to journalArticle

Abstract

We have created novel HER2-overexpressing human ovarian adenocarcinoma cell line stably transfected with far-red fluorescent protein TurboFP635. Growth characteristics, adhesion capacity and morphology of the cells do not differ from that of parental cell line. The obtained cell line (SKOV-kat) was confirmed to have high level of expression of the tumor marker HER2 comparable to that of initial cell line SKOV-3. The SKOV-kat cell line is designed for further establishment of experimental fluorescent models of HER2-overexpressing human ovarian cancer that make it possible to optimize and reduce the cost of preclinical study of agents for treatment of this disease.

Original languageEnglish
Pages (from-to)410-412
Number of pages3
JournalDoklady Biochemistry and Biophysics
Volume465
Issue number1
DOIs
Publication statusPublished - 1 Nov 2015
Externally publishedYes

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Cells
Cell Line
Tumor Biomarkers
Ovarian Neoplasms
Adenocarcinoma
Theoretical Models
Adhesion
Costs and Cost Analysis
Growth
Costs

ASJC Scopus subject areas

  • Biophysics
  • Chemistry(all)
  • Medicine(all)
  • Biochemistry

Cite this

Far-red fluorescent cell line for preclinical study of HER2-targeted agents. / Balalaeva, I. V.; Sokolova, E. A.; Brilkina, A. A.; Deyev, S. M.; Petrov, R. V.

In: Doklady Biochemistry and Biophysics, Vol. 465, No. 1, 01.11.2015, p. 410-412.

Research output: Contribution to journalArticle

Balalaeva, I. V. ; Sokolova, E. A. ; Brilkina, A. A. ; Deyev, S. M. ; Petrov, R. V. / Far-red fluorescent cell line for preclinical study of HER2-targeted agents. In: Doklady Biochemistry and Biophysics. 2015 ; Vol. 465, No. 1. pp. 410-412.
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