TY - JOUR
T1 - Exploring Brain Derived Neurotrophic Factor and Cell Adhesion Molecules as Biomarkers for the Transdiagnostic Symptom Anhedonia in Alcohol Use Disorder and Comorbid Depression
AU - Levchuk, Lyudmila A.
AU - Meeder, Elise M.G.
AU - Roschina, Olga V.
AU - Loonen, Anton J.M.
AU - Boiko, Anastasiia S.
AU - Michalitskaya, Ekaterina V.
AU - Epimakhova, Elena V.
AU - Losenkov, Innokentiy S.
AU - Simutkin, German G.
AU - Bokhan, Nikolay A.
AU - Schellekens, Arnt F.A.
AU - Ivanova, Svetlana A.
N1 - Funding Information:
The study was funded by a grant from the Russian Science Foundation (project No. 19-15-00023). The number of affiliations of the Russian contributors is required to be limited to a single (main) institution. This grant is applied to pay for reagents and salaries of Russian (co-)authors, as well as the publication fee.
Publisher Copyright:
© Copyright © 2020 Levchuk, Meeder, Roschina, Loonen, Boiko, Michalitskaya, Epimakhova, Losenkov, Simutkin, Bokhan, Schellekens and Ivanova.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/4/20
Y1 - 2020/4/20
N2 - Background: Alcohol Use Disorder (AUD) and depressive disorder often co-exist and have a shared heritability. This study aimed to investigate Brain-Derived Neurotrophic Factor (BDNF) and three Cell Adhesion Molecules (CAMs) as transdiagnostic biomarkers in AUD and depression co-morbidity. Methods: In a cross-sectional study, patients with AUD (n=22), AUD and depression (n=19), and healthy controls (n=20) were examined. Depression and anxiety severity were assessed using the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale. Anhedonia, alcohol use and dependence, craving, and social adaptation were assessed through self-report questionnaires. BDNF and CAM concentrations in peripheral serum were measured after overnight fasting using a Luminex assay. After controlling for age and gender, biomarker levels were compared across groups. The association between biomarker concentrations and symptom severity scales were explored using correlation and multiple regression analyses. Results: BDNF and Neuronal CAM were lower in patients with AUD with and without depression compared to healthy controls. No differences were observed for Vascular CAM-1 and Interstitial CAM-1. BDNF correlated negatively with anhedonia levels. BDNF, age and gender together explained 21% of variability in anhedonia levels. Conclusion: This pilot study suggests that peripheral levels of BDNF and NCAM might be reduced in AUD with and without comorbid mood disorder. Since low BDNF levels were associated with self- reported anhedonia across these conditions, BDNF and anhedonia might reflect transdiagnostic aspects involved in AUD and depression.
AB - Background: Alcohol Use Disorder (AUD) and depressive disorder often co-exist and have a shared heritability. This study aimed to investigate Brain-Derived Neurotrophic Factor (BDNF) and three Cell Adhesion Molecules (CAMs) as transdiagnostic biomarkers in AUD and depression co-morbidity. Methods: In a cross-sectional study, patients with AUD (n=22), AUD and depression (n=19), and healthy controls (n=20) were examined. Depression and anxiety severity were assessed using the Hamilton Depression Rating Scale and the Hamilton Anxiety Rating Scale. Anhedonia, alcohol use and dependence, craving, and social adaptation were assessed through self-report questionnaires. BDNF and CAM concentrations in peripheral serum were measured after overnight fasting using a Luminex assay. After controlling for age and gender, biomarker levels were compared across groups. The association between biomarker concentrations and symptom severity scales were explored using correlation and multiple regression analyses. Results: BDNF and Neuronal CAM were lower in patients with AUD with and without depression compared to healthy controls. No differences were observed for Vascular CAM-1 and Interstitial CAM-1. BDNF correlated negatively with anhedonia levels. BDNF, age and gender together explained 21% of variability in anhedonia levels. Conclusion: This pilot study suggests that peripheral levels of BDNF and NCAM might be reduced in AUD with and without comorbid mood disorder. Since low BDNF levels were associated with self- reported anhedonia across these conditions, BDNF and anhedonia might reflect transdiagnostic aspects involved in AUD and depression.
KW - addiction
KW - alcohol use disorder
KW - anhedonia
KW - biomarker
KW - brain-derived neurotrophic factor
KW - cell adhesion molecule
KW - depressive disorder
KW - transdiagnostic
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U2 - 10.3389/fpsyt.2020.00296
DO - 10.3389/fpsyt.2020.00296
M3 - Article
AN - SCOPUS:85084257293
VL - 11
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
SN - 1664-0640
M1 - 296
ER -