Experimental study of 99mTc-aluminum oxide use for sentinel lymph nodes detection

V. I. Chernov, I. G. Sinilkin, R. V. Zelchan, A. A. Medvedeva, A. Yu Lyapunov, O. D. Bragina, N. V. Varlamova, V. S. Skuridin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

The purpose of the study was a comparative research in the possibility of using the radiopharmaceuticals 99mTc-Al2O3 and 99mTc-Nanocis for visualizing sentinel lymph nodes. The measurement of the sizes of 99mTc-Al2O3 and 99mTc-Nanocis colloidal particles was performed in seven series of radiopharmaceuticals. The pharmacokinetics of 99mTc-Al2O3 and 99mTc-Nanocis was researched on 50 white male rats. The possibility of the use of 99mTc-Al2O3 and 99mTc-Nanocis for lymphoscintigraphy was studied in the experiments on 12 white male rats. The average dynamic diameter of the sol particle was 52-77 nm for 99mTc-Al2O3 and 16.7-24.5 nm for 99mTc-Nanocis. Radiopharmaceuticals accumulated in the inguinal lymph node in 1 hour after administration; the average uptake of 99mTc-Al2O3 was 8.6% in it, and the accumulation of 99mTc-Nanocis was significantly lower - 1.8% (p < 0.05). In all study points the average uptake of 99mTc-Al2O3 in the lymph node was significantly higher than 99mTc-Nanocis accumulation. The results of dynamic scintigraphic studies in rats showed that 99mTc-Al2O3 and 99mTc-Nanocis actively accumulated into the lymphatic system. By using 99mTc-Al2O3 inguinal lymph node was determined in 5 minutes after injection and clearly visualized in all the animals in the 15th minute, when the accumulation became more than 1% of the administered dose. Further observation indicated that the 99mTc-Al2O3 accumulation reached a plateau in a lymph node (average 10.5%) during 2-hour study and then its accumulation remained practically at the same level, slightly increasing to 12% in 24 hours. In case of 99mTc-Nanocis inguinal lymph node was visualized in all animals for 15 min when it was accumulated on the average 1.03% of the administered dose. Plateau of 99mTc-Nanocis accumulation in the lymph node (average 2.05%) occurred after 2 hours of the study and remained almost on the same level (in average 2.3%) for 24 hours. Thus, the experimental study of a new domestic radiopharmaceutical showed that the 99mTc-Al2O3 accumulates actively in the lymph nodes several times as compared to the imported analogue and its practical application will facilitate intraoperative identification of sentinel lymph nodes.

Original languageEnglish
Title of host publicationPhysics of Cancer
Subtitle of host publicationInterdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016
PublisherAmerican Institute of Physics Inc.
Volume1760
ISBN (Electronic)9780735414181
DOIs
Publication statusPublished - 2 Aug 2016
EventInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016 - Tomsk, Russian Federation
Duration: 22 Mar 201625 Mar 2016

Conference

ConferenceInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016
CountryRussian Federation
CityTomsk
Period22.3.1625.3.16

Fingerprint

lymphatic system
aluminum oxides
rats
animals
plateaus
dosage
analogs
injection

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Chernov, V. I., Sinilkin, I. G., Zelchan, R. V., Medvedeva, A. A., Lyapunov, A. Y., Bragina, O. D., ... Skuridin, V. S. (2016). Experimental study of 99mTc-aluminum oxide use for sentinel lymph nodes detection. In Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016 (Vol. 1760). [020012] American Institute of Physics Inc.. https://doi.org/10.1063/1.4960231

Experimental study of 99mTc-aluminum oxide use for sentinel lymph nodes detection. / Chernov, V. I.; Sinilkin, I. G.; Zelchan, R. V.; Medvedeva, A. A.; Lyapunov, A. Yu; Bragina, O. D.; Varlamova, N. V.; Skuridin, V. S.

Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016. Vol. 1760 American Institute of Physics Inc., 2016. 020012.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chernov, VI, Sinilkin, IG, Zelchan, RV, Medvedeva, AA, Lyapunov, AY, Bragina, OD, Varlamova, NV & Skuridin, VS 2016, Experimental study of 99mTc-aluminum oxide use for sentinel lymph nodes detection. in Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016. vol. 1760, 020012, American Institute of Physics Inc., International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016, Tomsk, Russian Federation, 22.3.16. https://doi.org/10.1063/1.4960231
Chernov VI, Sinilkin IG, Zelchan RV, Medvedeva AA, Lyapunov AY, Bragina OD et al. Experimental study of 99mTc-aluminum oxide use for sentinel lymph nodes detection. In Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016. Vol. 1760. American Institute of Physics Inc. 2016. 020012 https://doi.org/10.1063/1.4960231
Chernov, V. I. ; Sinilkin, I. G. ; Zelchan, R. V. ; Medvedeva, A. A. ; Lyapunov, A. Yu ; Bragina, O. D. ; Varlamova, N. V. ; Skuridin, V. S. / Experimental study of 99mTc-aluminum oxide use for sentinel lymph nodes detection. Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC 2016: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016. Vol. 1760 American Institute of Physics Inc., 2016.
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abstract = "The purpose of the study was a comparative research in the possibility of using the radiopharmaceuticals 99mTc-Al2O3 and 99mTc-Nanocis for visualizing sentinel lymph nodes. The measurement of the sizes of 99mTc-Al2O3 and 99mTc-Nanocis colloidal particles was performed in seven series of radiopharmaceuticals. The pharmacokinetics of 99mTc-Al2O3 and 99mTc-Nanocis was researched on 50 white male rats. The possibility of the use of 99mTc-Al2O3 and 99mTc-Nanocis for lymphoscintigraphy was studied in the experiments on 12 white male rats. The average dynamic diameter of the sol particle was 52-77 nm for 99mTc-Al2O3 and 16.7-24.5 nm for 99mTc-Nanocis. Radiopharmaceuticals accumulated in the inguinal lymph node in 1 hour after administration; the average uptake of 99mTc-Al2O3 was 8.6{\%} in it, and the accumulation of 99mTc-Nanocis was significantly lower - 1.8{\%} (p < 0.05). In all study points the average uptake of 99mTc-Al2O3 in the lymph node was significantly higher than 99mTc-Nanocis accumulation. The results of dynamic scintigraphic studies in rats showed that 99mTc-Al2O3 and 99mTc-Nanocis actively accumulated into the lymphatic system. By using 99mTc-Al2O3 inguinal lymph node was determined in 5 minutes after injection and clearly visualized in all the animals in the 15th minute, when the accumulation became more than 1{\%} of the administered dose. Further observation indicated that the 99mTc-Al2O3 accumulation reached a plateau in a lymph node (average 10.5{\%}) during 2-hour study and then its accumulation remained practically at the same level, slightly increasing to 12{\%} in 24 hours. In case of 99mTc-Nanocis inguinal lymph node was visualized in all animals for 15 min when it was accumulated on the average 1.03{\%} of the administered dose. Plateau of 99mTc-Nanocis accumulation in the lymph node (average 2.05{\%}) occurred after 2 hours of the study and remained almost on the same level (in average 2.3{\%}) for 24 hours. Thus, the experimental study of a new domestic radiopharmaceutical showed that the 99mTc-Al2O3 accumulates actively in the lymph nodes several times as compared to the imported analogue and its practical application will facilitate intraoperative identification of sentinel lymph nodes.",
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AU - Medvedeva, A. A.

AU - Lyapunov, A. Yu

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