Experimental pharmacokinetic and scintigraphic studies of <sup>99m</sup>Tc-techmicard

Abstract

Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, ^99mTc-techmikard, were carried out in 40 rats and 8 rabbits. pharmacokinetic characteristics of the agent prepared on the basis extraction stationary or absorption Tc generators were found Identical. Despite the fact that the pharmacokinetics of this agent differs from of ¹⁹⁹Tl, its rapid clearance from the blood, high factor of extraction the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the sterilization and three-hour storage after preparation of solution do influence its pharmacokinetics or quality of scintigrams.

Original language	English
Pages (from-to)	6-9
Number of pages	4
Journal	Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost
Volume	40
Issue number	2
Publication status	Published - 1995

Keywords

Tc-techmicard imaging
Myocardium

ASJC Scopus subject areas

Nuclear Energy and Engineering

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@article{b40320b8aa174f6a8b8f543f379d21c0,

title = "Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard",

abstract = "Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. pharmacokinetic characteristics of the agent prepared on the basis extraction stationary or absorption Tc generators were found Identical. Despite the fact that the pharmacokinetics of this agent differs from of 199Tl, its rapid clearance from the blood, high factor of extraction the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the sterilization and three-hour storage after preparation of solution do influence its pharmacokinetics or quality of scintigrams.",

keywords = "Tc-techmicard imaging, Myocardium",

author = "{Lishmanov Yu.}, B. and Chernov, {V. I.} and Krivonogov, {N. G.} and Malysheva, {A. O.} and {Vesnina Zh.}, V. and {Rebrova Yu.}, T. and {Shvera Yu.}, I.",

year = "1995",

language = "English",

volume = "40",

pages = "6--9",

journal = "Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'",

issn = "0025-8334",

publisher = "Izdatel'sto Radekon",

number = "2",

}

TY - JOUR

T1 - Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard

AU - Lishmanov Yu., B.

AU - Chernov, V. I.

AU - Krivonogov, N. G.

AU - Malysheva, A. O.

AU - Vesnina Zh., V.

AU - Rebrova Yu., T.

AU - Shvera Yu., I.

PY - 1995

Y1 - 1995

N2 - Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. pharmacokinetic characteristics of the agent prepared on the basis extraction stationary or absorption Tc generators were found Identical. Despite the fact that the pharmacokinetics of this agent differs from of 199Tl, its rapid clearance from the blood, high factor of extraction the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the sterilization and three-hour storage after preparation of solution do influence its pharmacokinetics or quality of scintigrams.

AB - Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. pharmacokinetic characteristics of the agent prepared on the basis extraction stationary or absorption Tc generators were found Identical. Despite the fact that the pharmacokinetics of this agent differs from of 199Tl, its rapid clearance from the blood, high factor of extraction the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the sterilization and three-hour storage after preparation of solution do influence its pharmacokinetics or quality of scintigrams.

KW - Tc-techmicard imaging

KW - Myocardium

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VL - 40

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JF - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'

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