Abstract
Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. pharmacokinetic characteristics of the agent prepared on the basis extraction stationary or absorption Tc generators were found Identical. Despite the fact that the pharmacokinetics of this agent differs from of 199Tl, its rapid clearance from the blood, high factor of extraction the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the sterilization and three-hour storage after preparation of solution do influence its pharmacokinetics or quality of scintigrams.
| Original language | English |
|---|---|
| Pages (from-to) | 6-9 |
| Number of pages | 4 |
| Journal | Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost |
| Volume | 40 |
| Issue number | 2 |
| Publication status | Published - 1995 |
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Keywords
- Tc-techmicard imaging
- Myocardium
ASJC Scopus subject areas
- Nuclear Energy and Engineering
Cite this
Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard. / Lishmanov Yu., B.; Chernov, V. I.; Krivonogov, N. G.; Malysheva, A. O.; Vesnina Zh., V.; Rebrova Yu., T.; Shvera Yu., I.
In: Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost, Vol. 40, No. 2, 1995, p. 6-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard
AU - Lishmanov Yu., B.
AU - Chernov, V. I.
AU - Krivonogov, N. G.
AU - Malysheva, A. O.
AU - Vesnina Zh., V.
AU - Rebrova Yu., T.
AU - Shvera Yu., I.
PY - 1995
Y1 - 1995
N2 - Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. pharmacokinetic characteristics of the agent prepared on the basis extraction stationary or absorption Tc generators were found Identical. Despite the fact that the pharmacokinetics of this agent differs from of 199Tl, its rapid clearance from the blood, high factor of extraction the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the sterilization and three-hour storage after preparation of solution do influence its pharmacokinetics or quality of scintigrams.
AB - Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. pharmacokinetic characteristics of the agent prepared on the basis extraction stationary or absorption Tc generators were found Identical. Despite the fact that the pharmacokinetics of this agent differs from of 199Tl, its rapid clearance from the blood, high factor of extraction the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the sterilization and three-hour storage after preparation of solution do influence its pharmacokinetics or quality of scintigrams.
KW - Tc-techmicard imaging
KW - Myocardium
UR - http://www.scopus.com/inward/record.url?scp=0029014768&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029014768&partnerID=8YFLogxK
M3 - Article
VL - 40
SP - 6
EP - 9
JO - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
JF - Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost'
SN - 0025-8334
IS - 2
ER -