Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard

Yu B. Lishmanov, V. I. Chernov, N. G. Krivonogov, A. O. Malysheva, Zh V. Vesnina, T. Yu Rebrova, R. Yu Shvera

Research output: Contribution to journalArticle

Abstract

Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. The pharmacokinetic characteristics of the agent prepared on the basis of extraction stationary or absorption Tc generators were found identical. Despite the fact that the pharmacokinetics of this agent differs from that of 199Tl, its rapid clearance from the blood, high factor of extraction by the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the reagent sterillization and three-hour storage after preparation of solution do not influence its pharmacokinetics or quality of scintigrams.

Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalMeditsina Truda I Promyshlennaya Ekologiya
Issue number9
Publication statusPublished - Sep 1995

Fingerprint

Pharmacokinetics
Radiopharmaceuticals
Rats
Animals
Blood
Imaging techniques

ASJC Scopus subject areas

  • Chemical Health and Safety
  • Industrial and Manufacturing Engineering
  • Safety, Risk, Reliability and Quality

Cite this

Lishmanov, Y. B., Chernov, V. I., Krivonogov, N. G., Malysheva, A. O., Vesnina, Z. V., Rebrova, T. Y., & Shvera, R. Y. (1995). Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard. Meditsina Truda I Promyshlennaya Ekologiya, (9), 6-9.

Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard. / Lishmanov, Yu B.; Chernov, V. I.; Krivonogov, N. G.; Malysheva, A. O.; Vesnina, Zh V.; Rebrova, T. Yu; Shvera, R. Yu.

In: Meditsina Truda I Promyshlennaya Ekologiya, No. 9, 09.1995, p. 6-9.

Research output: Contribution to journalArticle

Lishmanov, YB, Chernov, VI, Krivonogov, NG, Malysheva, AO, Vesnina, ZV, Rebrova, TY & Shvera, RY 1995, 'Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard', Meditsina Truda I Promyshlennaya Ekologiya, no. 9, pp. 6-9.
Lishmanov YB, Chernov VI, Krivonogov NG, Malysheva AO, Vesnina ZV, Rebrova TY et al. Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard. Meditsina Truda I Promyshlennaya Ekologiya. 1995 Sep;(9):6-9.
Lishmanov, Yu B. ; Chernov, V. I. ; Krivonogov, N. G. ; Malysheva, A. O. ; Vesnina, Zh V. ; Rebrova, T. Yu ; Shvera, R. Yu. / Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard. In: Meditsina Truda I Promyshlennaya Ekologiya. 1995 ; No. 9. pp. 6-9.
@article{bc3f8392558b4863bb92315d19bae741,
title = "Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard",
abstract = "Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. The pharmacokinetic characteristics of the agent prepared on the basis of extraction stationary or absorption Tc generators were found identical. Despite the fact that the pharmacokinetics of this agent differs from that of 199Tl, its rapid clearance from the blood, high factor of extraction by the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the reagent sterillization and three-hour storage after preparation of solution do not influence its pharmacokinetics or quality of scintigrams.",
author = "Lishmanov, {Yu B.} and Chernov, {V. I.} and Krivonogov, {N. G.} and Malysheva, {A. O.} and Vesnina, {Zh V.} and Rebrova, {T. Yu} and Shvera, {R. Yu}",
year = "1995",
month = "9",
language = "English",
pages = "6--9",
journal = "Gigiena Truda i Professionalnye Zabolevaniya",
issn = "0016-9919",
publisher = "Institut Meditsiny Truda",
number = "9",

}

TY - JOUR

T1 - Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard

AU - Lishmanov, Yu B.

AU - Chernov, V. I.

AU - Krivonogov, N. G.

AU - Malysheva, A. O.

AU - Vesnina, Zh V.

AU - Rebrova, T. Yu

AU - Shvera, R. Yu

PY - 1995/9

Y1 - 1995/9

N2 - Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. The pharmacokinetic characteristics of the agent prepared on the basis of extraction stationary or absorption Tc generators were found identical. Despite the fact that the pharmacokinetics of this agent differs from that of 199Tl, its rapid clearance from the blood, high factor of extraction by the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the reagent sterillization and three-hour storage after preparation of solution do not influence its pharmacokinetics or quality of scintigrams.

AB - Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. The pharmacokinetic characteristics of the agent prepared on the basis of extraction stationary or absorption Tc generators were found identical. Despite the fact that the pharmacokinetics of this agent differs from that of 199Tl, its rapid clearance from the blood, high factor of extraction by the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the reagent sterillization and three-hour storage after preparation of solution do not influence its pharmacokinetics or quality of scintigrams.

UR - http://www.scopus.com/inward/record.url?scp=0029370806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029370806&partnerID=8YFLogxK

M3 - Article

SP - 6

EP - 9

JO - Gigiena Truda i Professionalnye Zabolevaniya

JF - Gigiena Truda i Professionalnye Zabolevaniya

SN - 0016-9919

IS - 9

ER -