Experimental pharmacokinetic and scintigraphic studies of <sup>99m</sup>Tc-techmicard

Abstract

Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, ^99mTc-techmikard, were carried out in 40 rats and 8 rabbits. The pharmacokinetic characteristics of the agent prepared on the basis of extraction stationary or absorption Tc generators were found identical. Despite the fact that the pharmacokinetics of this agent differs from that of ¹⁹⁹Tl, its rapid clearance from the blood, high factor of extraction by the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the reagent sterillization and three-hour storage after preparation of solution do not influence its pharmacokinetics or quality of scintigrams.

Original language	English
Pages (from-to)	6-9
Number of pages	4
Journal	Meditsina Truda I Promyshlennaya Ekologiya
Issue number	9
Publication status	Published - Sep 1995

ASJC Scopus subject areas

Chemical Health and Safety
Industrial and Manufacturing Engineering
Safety, Risk, Reliability and Quality

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Lishmanov, Y. B., Chernov, V. I., Krivonogov, N. G., Malysheva, A. O., Vesnina, Z. V., Rebrova, T. Y., & Shvera, R. Y. (1995). Experimental pharmacokinetic and scintigraphic studies of ^99mTc-techmicard. Meditsina Truda I Promyshlennaya Ekologiya, (9), 6-9.

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title = "Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard",

abstract = "Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. The pharmacokinetic characteristics of the agent prepared on the basis of extraction stationary or absorption Tc generators were found identical. Despite the fact that the pharmacokinetics of this agent differs from that of 199Tl, its rapid clearance from the blood, high factor of extraction by the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the reagent sterillization and three-hour storage after preparation of solution do not influence its pharmacokinetics or quality of scintigrams.",

author = "Lishmanov, {Yu B.} and Chernov, {V. I.} and Krivonogov, {N. G.} and Malysheva, {A. O.} and Vesnina, {Zh V.} and Rebrova, {T. Yu} and Shvera, {R. Yu}",

year = "1995",

month = sep,

language = "English",

pages = "6--9",

journal = "Gigiena Truda i Professionalnye Zabolevaniya",

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T1 - Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard

AU - Lishmanov, Yu B.

AU - Chernov, V. I.

AU - Krivonogov, N. G.

AU - Malysheva, A. O.

AU - Vesnina, Zh V.

AU - Rebrova, T. Yu

AU - Shvera, R. Yu

PY - 1995/9

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N2 - Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. The pharmacokinetic characteristics of the agent prepared on the basis of extraction stationary or absorption Tc generators were found identical. Despite the fact that the pharmacokinetics of this agent differs from that of 199Tl, its rapid clearance from the blood, high factor of extraction by the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the reagent sterillization and three-hour storage after preparation of solution do not influence its pharmacokinetics or quality of scintigrams.

AB - Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. The pharmacokinetic characteristics of the agent prepared on the basis of extraction stationary or absorption Tc generators were found identical. Despite the fact that the pharmacokinetics of this agent differs from that of 199Tl, its rapid clearance from the blood, high factor of extraction by the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the reagent sterillization and three-hour storage after preparation of solution do not influence its pharmacokinetics or quality of scintigrams.

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