Expedient synthesis of long-chain ω-substituted fatty acids and esters from cyclic ketones using iodine and hydrogen peroxide

Research output: Contribution to journalArticle


A simple and convenient synthesis of ω-iodoaliphatic carboxylic acids and esters by the reaction of cyclic ketones with iodine and hydrogen peroxide in the presence of catalytic CuCl has been developed. ω-Iodoaliphatic carboxylic esters were further used for the efficient preparation of di(2-pyridylmethylamino)alkanoic acids in excellent yields.

Original languageEnglish
Pages (from-to)4081-4088
Number of pages8
JournalSynthesis (Germany)
Issue number20
Publication statusPublished - 1 Jan 2018



  • chelating reagents
  • cyclic ketones
  • di-(2-picolyl)amine
  • di-(2-pyridylmethylamino)alkanoic acids
  • ligands
  • ω-iodo-aliphatic carboxylic esters
  • ω-iodoaliphatic carboxylic acids

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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