Abstract
A simple and convenient synthesis of ω-iodoaliphatic carboxylic acids and esters by the reaction of cyclic ketones with iodine and hydrogen peroxide in the presence of catalytic CuCl has been developed. ω-Iodoaliphatic carboxylic esters were further used for the efficient preparation of di(2-pyridylmethylamino)alkanoic acids in excellent yields.
| Original language | English |
|---|---|
| Pages (from-to) | 4081-4088 |
| Number of pages | 8 |
| Journal | Synthesis (Germany) |
| Volume | 50 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
Keywords
- chelating reagents
- cyclic ketones
- di-(2-picolyl)amine
- di-(2-pyridylmethylamino)alkanoic acids
- ligands
- ω-iodo-aliphatic carboxylic esters
- ω-iodoaliphatic carboxylic acids
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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Cite this
Podrezova, E. V., Larkina, M. S., Belousov, M. V., Kirschning, A., Zhdankin, V. V., & Yusubov, M. S. (2018). Expedient synthesis of long-chain ω-substituted fatty acids and esters from cyclic ketones using iodine and hydrogen peroxide. Synthesis (Germany), 50(20), 4081-4088. https://doi.org/10.1055/s-0036-1591598