TY - JOUR
T1 - Exercise and NO production
T2 - Relevance and implications in the cardiopulmonary system
AU - Nosarev, Alexei V.
AU - Smagliy, Lyudmila V.
AU - Anfinogenova, Yana
AU - Popov, Sergey V.
AU - Kapilevich, Leonid V.
N1 - Publisher Copyright:
© 2015 Nosarev, Smagliy, Anfinogenova, Popov and Kapilevich.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2015/1/7
Y1 - 2015/1/7
N2 - This article reviews the existing knowledge about the effects of physical exercise on nitric oxide (NO) production in the cardiopulmonary system. The authors review the sources of NO in the cardiopulmonary system; involvement of three forms of NO synthases (eNOS, nNOS, and iNOS) in exercise physiology; exercise-induced modulation of NO and/or NOS in physiological and pathophysiological conditions in human subjects and animal models in the absence and presence of pharmacological modulators; and significance of exercise-induced NO production in health and disease. The authors suggest that physical activity significantly improves functioning of the cardiovascular system through an increase in NO bioavailability, potentiation of antioxidant defense, and decrease in the expression of reactive oxygen species-forming enzymes. Regular physical exercises are considered a useful approach to treat cardiovascular diseases. Future studies should focus on detailed identification of (i) the exercise-mediated mechanisms of NO exchange; (ii) optimal exercise approaches to improve cardiovascular function in health and disease; and (iii) physical effort thresholds.
AB - This article reviews the existing knowledge about the effects of physical exercise on nitric oxide (NO) production in the cardiopulmonary system. The authors review the sources of NO in the cardiopulmonary system; involvement of three forms of NO synthases (eNOS, nNOS, and iNOS) in exercise physiology; exercise-induced modulation of NO and/or NOS in physiological and pathophysiological conditions in human subjects and animal models in the absence and presence of pharmacological modulators; and significance of exercise-induced NO production in health and disease. The authors suggest that physical activity significantly improves functioning of the cardiovascular system through an increase in NO bioavailability, potentiation of antioxidant defense, and decrease in the expression of reactive oxygen species-forming enzymes. Regular physical exercises are considered a useful approach to treat cardiovascular diseases. Future studies should focus on detailed identification of (i) the exercise-mediated mechanisms of NO exchange; (ii) optimal exercise approaches to improve cardiovascular function in health and disease; and (iii) physical effort thresholds.
KW - Blood vessels
KW - Cardiopulmonary system
KW - Exercise
KW - Nitric oxide
KW - Nitric oxide synthase
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U2 - 10.3389/fcell.2014.00073
DO - 10.3389/fcell.2014.00073
M3 - Review article
AN - SCOPUS:85021149367
VL - 2
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
SN - 2296-634X
IS - JAN
M1 - 73
ER -