Evaluation of manganese -trans-1,2-diaminocyclohexane-N,N,N′, N′-tetraacetate complex (Cyclomang) as paramagnetic contrast agent for magnetic resonance imaging

V. Yu Usov, M. L. Belyanin, A. I. Bezlepkin, A. A. Churin, T. Yu Dubskaya, T. L. Vetoshkina, V. D. Filimonov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Preclinical evaluation of a 0.5 M solution of the manganese(II) - trans-1,2-diaminocyclohexane-N,N,N′,N′-tetraacetate complex (Mn-DCTA, Cyclomang) has been carried out with a view to substitution of potentially toxic gadolinium-containing paramagnetic contrast agents for clinical MRI routines. The toxicological tests of Mn(II)-DCTA were performed on mice and rats. Liquid phantoms were used for evaluating the relaxivity of Mn(II)-DCTA in comparison to that of Gd(III)-DTPA and Mn-DTPA. The diagnostic imaging properties of Mn(II)-DCTA were quantitatively assessed on dogs with cerebral meningeomas (n = 10). The LD50 upon single administration in rats was above 17 ml/kg, thus slightly exceeding the corresponding values for of Gd(III)-DTPA and Mn-DTPA. The relaxivity of Mn(II)-DCTA amounted to R1 =3.68 (mM-1 · s-1) and did not differ significantly from the values known for Gd-DTPA and Mn-DTPA. Mn(II)-DCTA ensured high-intensity contrast of tumor areas in brain of dogs. It is concluded that Mn(II)-DCTA can be employed as a paramagnetic contrast agent in routine MRI studies and is worth further clinical evaluation.

Original languageEnglish
Pages (from-to)32-38
Number of pages7
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume76
Issue number10
Publication statusPublished - 1 Jan 2013

Keywords

  • Manganeses(II) - trans-1,2-diaminocyclohexane-N,N,N′,N′- tetraacetate (Mn-DCTA)
  • MRI
  • Paramagnetic enhancement
  • Preclinical evaluation

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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