Evaluation of brain tumor endothelial permeability by dynamic magnetic resonance Magnevist contrast imaging with on a low-table MR-tomograph

V. Yu Usov, O. B. Velichko, O. Yu Borodin, A. B. Garganeev, A. A. Shikunov, O. N. Boklag

Research output: Contribution to journalArticlepeer-review

Abstract

In order to study the endothelial permeability to hydrophilic macromolecules in brain tumors we have developed a technique based on Gjedde-Rutland-Patlak approach to dynamic MRI study with Gd-DTPA injected intravenously, performed with low-field MRI tomograph Magnetom Open (Siemens medical). 27 patients with various brain tumors were referred for the study. The indices of Gd-DTPA transport to tumor tissue (KGd-DTPA) vary substantially, depending on the degree of malignancy and deliver essential information on microvascular permeability of tumor capillary bed.

Original languageEnglish
Pages (from-to)22-29
Number of pages8
JournalVestnik Rentgenologii i Radiologii
Issue number3
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • CNS tumors
  • Dynamic MRI
  • Gd-DTPA
  • Vascular permeability

ASJC Scopus subject areas

  • Medicine(all)

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