ERBB oncogene proteins as targets for monoclonal antibodies

O. L. Polanovski, E. N. Lebedenko, S. M. Deyev

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

General properties of the family of tyrosine kinase ERBB receptors are considered in connection with their role in the generation of cascades of signal transduction in normal and tumor cells. Causes of acquisition of oncogene features by genes encoding these receptors and their role in tumorigenesis are analyzed. Anti-ERBB monoclonal antibodies approved for therapy are described in detail, and mechanisms of their antitumor activity and development of resistance to them are reviewed. The existing and the most promising strategies for creating and using monoclonal antibodies and their derivatives for therapy of cancer are discussed.

Original languageEnglish
Pages (from-to)227-245
Number of pages19
JournalBiochemistry (Moscow)
Volume77
Issue number3
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

Keywords

  • EGFR
  • HER2/neu
  • Herceptin
  • Receptor tyrosine kinases ERBB1-4
  • Signaling cascades

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)

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