The contribution of calmodulin and protein kinase C to the regulation of epithelial relaxing factor production by the tracheal epithelium and the role of adenylate and guanylate cyclase in the realization of the effect of this factor on airway smooth muscles are studied by the mechanographic method with cascade perfusion. Calmodulin and protein kinase C are shown to participate in the production of relaxing factor by epitheliocytes, guanylate cyclase being the principal target in exposure of smooth muscles to epithelial relaxing factor.
- smooth muscles
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)