Epithelium-dependent regulation of smooth muscle contractility of the airways

L. V. Kapilevich, M. B. Baskakov, M. A. Medvedev, E. Yu Petrov, M. V. Kuskov, V. Yu Timofeev, I. V. Kovalev

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The contribution of calmodulin and protein kinase C to the regulation of epithelial relaxing factor production by the tracheal epithelium and the role of adenylate and guanylate cyclase in the realization of the effect of this factor on airway smooth muscles are studied by the mechanographic method with cascade perfusion. Calmodulin and protein kinase C are shown to participate in the production of relaxing factor by epitheliocytes, guanylate cyclase being the principal target in exposure of smooth muscles to epithelial relaxing factor.

Original languageEnglish
Pages (from-to)273-275
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume119
Issue number3
DOIs
Publication statusPublished - Mar 1995

Keywords

  • contraction
  • epithelium
  • smooth muscles
  • trachea

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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