Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: A possible mechanism

A. V. Krylatov, R. V. Uzhachenko, L. N. Maslov, N. A. Bernatskaya, A. Makriyannis, R. Mechoulam, R. G. Pertwee, O. M. Sal'nikova, J. B. Stefano, Yu B. Lishmanov

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22 Citations (Scopus)

Abstract

Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion. This antiarrhythmic effect was not associated with activation of NO synthase, since pretreatment with NG-nitro-L-arginine methyl ester had no effect on the incidence of ischemia/reperfusion-induced arrhythmias. Blockade of ATP-dependent K+ channels with glybenclamide did not abolish the antiarrhythmic effect of R-(+)-methanandamide. Antiarrhythmic activity of endogenous cannabinoids is probably associated with their direct effects on the myocardium.

Original languageEnglish
Pages (from-to)122-124
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume133
Issue number2
DOIs
Publication statusPublished - 26 Aug 2002

Keywords

  • Arrhythmias
  • Cannabinoid receptors
  • Endogenous cannabinoids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Krylatov, A. V., Uzhachenko, R. V., Maslov, L. N., Bernatskaya, N. A., Makriyannis, A., Mechoulam, R., Pertwee, R. G., Sal'nikova, O. M., Stefano, J. B., & Lishmanov, Y. B. (2002). Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: A possible mechanism. Bulletin of Experimental Biology and Medicine, 133(2), 122-124. https://doi.org/10.1023/A:1015574100494