Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion

A possible mechanism

A. V. Krylatov, R. V. Uzhachenko, L. N. Maslov, N. A. Bernatskaya, A. Makriyannis, R. Mechoulam, R. G. Pertwee, O. M. Sal'nikova, J. B. Stefano, Yu B. Lishmanov

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion. This antiarrhythmic effect was not associated with activation of NO synthase, since pretreatment with NG-nitro-L-arginine methyl ester had no effect on the incidence of ischemia/reperfusion-induced arrhythmias. Blockade of ATP-dependent K+ channels with glybenclamide did not abolish the antiarrhythmic effect of R-(+)-methanandamide. Antiarrhythmic activity of endogenous cannabinoids is probably associated with their direct effects on the myocardium.

Original languageEnglish
Pages (from-to)122-124
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume133
Issue number2
DOIs
Publication statusPublished - 26 Aug 2002

Fingerprint

Myocardial Reperfusion
Cannabinoids
Coronary Occlusion
Cardiac Arrhythmias
Cannabinoid Receptors
Glyburide
NG-Nitroarginine Methyl Ester
Nitric Oxide Synthase
Reperfusion
Myocardium
Ischemia
Adenosine Triphosphate
Chemical activation
Incidence
Enzymes
methanandamide
anandamide

Keywords

  • Arrhythmias
  • Cannabinoid receptors
  • Endogenous cannabinoids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion : A possible mechanism. / Krylatov, A. V.; Uzhachenko, R. V.; Maslov, L. N.; Bernatskaya, N. A.; Makriyannis, A.; Mechoulam, R.; Pertwee, R. G.; Sal'nikova, O. M.; Stefano, J. B.; Lishmanov, Yu B.

In: Bulletin of Experimental Biology and Medicine, Vol. 133, No. 2, 26.08.2002, p. 122-124.

Research output: Contribution to journalArticle

Krylatov, AV, Uzhachenko, RV, Maslov, LN, Bernatskaya, NA, Makriyannis, A, Mechoulam, R, Pertwee, RG, Sal'nikova, OM, Stefano, JB & Lishmanov, YB 2002, 'Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: A possible mechanism', Bulletin of Experimental Biology and Medicine, vol. 133, no. 2, pp. 122-124. https://doi.org/10.1023/A:1015574100494
Krylatov, A. V. ; Uzhachenko, R. V. ; Maslov, L. N. ; Bernatskaya, N. A. ; Makriyannis, A. ; Mechoulam, R. ; Pertwee, R. G. ; Sal'nikova, O. M. ; Stefano, J. B. ; Lishmanov, Yu B. / Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion : A possible mechanism. In: Bulletin of Experimental Biology and Medicine. 2002 ; Vol. 133, No. 2. pp. 122-124.
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