Abstract
Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion. This antiarrhythmic effect was not associated with activation of NO synthase, since pretreatment with NG-nitro-L-arginine methyl ester had no effect on the incidence of ischemia/reperfusion-induced arrhythmias. Blockade of ATP-dependent K+ channels with glybenclamide did not abolish the antiarrhythmic effect of R-(+)-methanandamide. Antiarrhythmic activity of endogenous cannabinoids is probably associated with their direct effects on the myocardium.
| Original language | English |
|---|---|
| Pages (from-to) | 122-124 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 133 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 26 Aug 2002 |
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Keywords
- Arrhythmias
- Cannabinoid receptors
- Endogenous cannabinoids
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion : A possible mechanism. / Krylatov, A. V.; Uzhachenko, R. V.; Maslov, L. N.; Bernatskaya, N. A.; Makriyannis, A.; Mechoulam, R.; Pertwee, R. G.; Sal'nikova, O. M.; Stefano, J. B.; Lishmanov, Yu B.
In: Bulletin of Experimental Biology and Medicine, Vol. 133, No. 2, 26.08.2002, p. 122-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion
T2 - A possible mechanism
AU - Krylatov, A. V.
AU - Uzhachenko, R. V.
AU - Maslov, L. N.
AU - Bernatskaya, N. A.
AU - Makriyannis, A.
AU - Mechoulam, R.
AU - Pertwee, R. G.
AU - Sal'nikova, O. M.
AU - Stefano, J. B.
AU - Lishmanov, Yu B.
PY - 2002/8/26
Y1 - 2002/8/26
N2 - Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion. This antiarrhythmic effect was not associated with activation of NO synthase, since pretreatment with NG-nitro-L-arginine methyl ester had no effect on the incidence of ischemia/reperfusion-induced arrhythmias. Blockade of ATP-dependent K+ channels with glybenclamide did not abolish the antiarrhythmic effect of R-(+)-methanandamide. Antiarrhythmic activity of endogenous cannabinoids is probably associated with their direct effects on the myocardium.
AB - Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion. This antiarrhythmic effect was not associated with activation of NO synthase, since pretreatment with NG-nitro-L-arginine methyl ester had no effect on the incidence of ischemia/reperfusion-induced arrhythmias. Blockade of ATP-dependent K+ channels with glybenclamide did not abolish the antiarrhythmic effect of R-(+)-methanandamide. Antiarrhythmic activity of endogenous cannabinoids is probably associated with their direct effects on the myocardium.
KW - Arrhythmias
KW - Cannabinoid receptors
KW - Endogenous cannabinoids
UR - http://www.scopus.com/inward/record.url?scp=0036345306&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036345306&partnerID=8YFLogxK
U2 - 10.1023/A:1015574100494
DO - 10.1023/A:1015574100494
M3 - Article
C2 - 12428277
AN - SCOPUS:0036345306
VL - 133
SP - 122
EP - 124
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 2
ER -