Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity

Abstract

Sea buckthorn (Hippophae Rhamnoides L.) is widespread in Altai region of Russia. For centuries this plant is used as a medicinal agent. In the present work separation of water extract of sea buckthorn bark into the ellagitannic and alkaloid fractions was carried out and influence of these fractions on the lymphocyte proliferation and cytokine production by lymphocytes (in vitro) was investigated. The ellagitannic fraction revealed concentration-dependent cytotoxicity. The alkaloid fraction in concentrations less than 0.2 mg/ml caused an increase in the proliferation of lymphocytes and stimulated the cytokine production. In higher concentrations both alkaloid and ellagitannic fractions showed cytotoxic effect.

Original language	English
Title of host publication	Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology
Subtitle of host publication	7th Korea-Russia International Symposium on Science and Technology
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	18-21
Number of pages	4
Volume	4
ISBN (Electronic)	8978686206, 9788978686204
Publication status	Published - 2003
Externally published	Yes
Event	7th Korea-Russia International Symposium on Science and Technology, KORUS 2003 - Ulsan, Korea, Republic of Duration: 28 Jun 2003 → 6 Jul 2003

Conference

Conference	7th Korea-Russia International Symposium on Science and Technology, KORUS 2003
Country	Korea, Republic of
City	Ulsan
Period	28.6.03 → 6.7.03

Keywords

Alkaloids
Cytokine production
Fractionation
Lymphocyte proliferation
Sea buckthorn bark
Tannins

ASJC Scopus subject areas

Building and Construction
Pollution
Biotechnology
Social Sciences (miscellaneous)
Medicine (miscellaneous)
Education

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Cite this

Chernov, M., Schepetkin, I., Ah, S. Y., Khlebnikov, A. I., Klubachuk, O., & Kwon, B. S. (2003). Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity. In Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology: 7th Korea-Russia International Symposium on Science and Technology (Vol. 4, pp. 18-21). [1222885] Institute of Electrical and Electronics Engineers Inc..

Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity. / Chernov, Mikhail; Schepetkin, Igor; Ah, Shin Young; Khlebnikov, Andrey Ivanovich; Klubachuk, Olesya; Kwon, Byoung Se.

Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology: 7th Korea-Russia International Symposium on Science and Technology. Vol. 4 Institute of Electrical and Electronics Engineers Inc., 2003. p. 18-21 1222885.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chernov, M, Schepetkin, I, Ah, SY, Khlebnikov, AI, Klubachuk, O & Kwon, BS 2003, Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity. in Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology: 7th Korea-Russia International Symposium on Science and Technology. vol. 4, 1222885, Institute of Electrical and Electronics Engineers Inc., pp. 18-21, 7th Korea-Russia International Symposium on Science and Technology, KORUS 2003, Ulsan, Korea, Republic of, 28.6.03.

Chernov M, Schepetkin I, Ah SY, Khlebnikov AI, Klubachuk O, Kwon BS. Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity. In Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology: 7th Korea-Russia International Symposium on Science and Technology. Vol. 4. Institute of Electrical and Electronics Engineers Inc. 2003. p. 18-21. 1222885

Chernov, Mikhail ; Schepetkin, Igor ; Ah, Shin Young ; Khlebnikov, Andrey Ivanovich ; Klubachuk, Olesya ; Kwon, Byoung Se. / Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity. Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology: 7th Korea-Russia International Symposium on Science and Technology. Vol. 4 Institute of Electrical and Electronics Engineers Inc., 2003. pp. 18-21

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keywords = "Alkaloids, Cytokine production, Fractionation, Lymphocyte proliferation, Sea buckthorn bark, Tannins",

author = "Mikhail Chernov and Igor Schepetkin and Ah, {Shin Young} and Khlebnikov, {Andrey Ivanovich} and Olesya Klubachuk and Kwon, {Byoung Se}",

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AU - Chernov, Mikhail

AU - Schepetkin, Igor

AU - Ah, Shin Young

AU - Khlebnikov, Andrey Ivanovich

AU - Klubachuk, Olesya

AU - Kwon, Byoung Se

PY - 2003

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N2 - Sea buckthorn (Hippophae Rhamnoides L.) is widespread in Altai region of Russia. For centuries this plant is used as a medicinal agent. In the present work separation of water extract of sea buckthorn bark into the ellagitannic and alkaloid fractions was carried out and influence of these fractions on the lymphocyte proliferation and cytokine production by lymphocytes (in vitro) was investigated. The ellagitannic fraction revealed concentration-dependent cytotoxicity. The alkaloid fraction in concentrations less than 0.2 mg/ml caused an increase in the proliferation of lymphocytes and stimulated the cytokine production. In higher concentrations both alkaloid and ellagitannic fractions showed cytotoxic effect.

AB - Sea buckthorn (Hippophae Rhamnoides L.) is widespread in Altai region of Russia. For centuries this plant is used as a medicinal agent. In the present work separation of water extract of sea buckthorn bark into the ellagitannic and alkaloid fractions was carried out and influence of these fractions on the lymphocyte proliferation and cytokine production by lymphocytes (in vitro) was investigated. The ellagitannic fraction revealed concentration-dependent cytotoxicity. The alkaloid fraction in concentrations less than 0.2 mg/ml caused an increase in the proliferation of lymphocytes and stimulated the cytokine production. In higher concentrations both alkaloid and ellagitannic fractions showed cytotoxic effect.

KW - Alkaloids

KW - Cytokine production

KW - Fractionation

KW - Lymphocyte proliferation

KW - Sea buckthorn bark

KW - Tannins

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