Abstract
Sea buckthorn (Hippophae Rhamnoides L.) is widespread in Altai region of Russia. For centuries this plant is used as a medicinal agent. In the present work separation of water extract of sea buckthorn bark into the ellagitannic and alkaloid fractions was carried out and influence of these fractions on the lymphocyte proliferation and cytokine production by lymphocytes (in vitro) was investigated. The ellagitannic fraction revealed concentration-dependent cytotoxicity. The alkaloid fraction in concentrations less than 0.2 mg/ml caused an increase in the proliferation of lymphocytes and stimulated the cytokine production. In higher concentrations both alkaloid and ellagitannic fractions showed cytotoxic effect.
| Original language | English |
|---|---|
| Title of host publication | Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology |
| Subtitle of host publication | 7th Korea-Russia International Symposium on Science and Technology |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 18-21 |
| Number of pages | 4 |
| Volume | 4 |
| ISBN (Electronic) | 8978686206, 9788978686204 |
| Publication status | Published - 2003 |
| Externally published | Yes |
| Event | 7th Korea-Russia International Symposium on Science and Technology, KORUS 2003 - Ulsan, Korea, Republic of Duration: 28 Jun 2003 → 6 Jul 2003 |
Conference
| Conference | 7th Korea-Russia International Symposium on Science and Technology, KORUS 2003 |
|---|---|
| Country | Korea, Republic of |
| City | Ulsan |
| Period | 28.6.03 → 6.7.03 |
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Keywords
- Alkaloids
- Cytokine production
- Fractionation
- Lymphocyte proliferation
- Sea buckthorn bark
- Tannins
ASJC Scopus subject areas
- Building and Construction
- Pollution
- Biotechnology
- Social Sciences (miscellaneous)
- Medicine (miscellaneous)
- Education
Cite this
Chernov, M., Schepetkin, I., Ah, S. Y., Khlebnikov, A. I., Klubachuk, O., & Kwon, B. S. (2003). Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity. In Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology: 7th Korea-Russia International Symposium on Science and Technology (Vol. 4, pp. 18-21). [1222885] Institute of Electrical and Electronics Engineers Inc..