Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity

Mikhail Chernov, Igor Schepetkin, Shin Young Ah, Andrey Ivanovich Khlebnikov, Olesya Klubachuk, Byoung Se Kwon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Sea buckthorn (Hippophae Rhamnoides L.) is widespread in Altai region of Russia. For centuries this plant is used as a medicinal agent. In the present work separation of water extract of sea buckthorn bark into the ellagitannic and alkaloid fractions was carried out and influence of these fractions on the lymphocyte proliferation and cytokine production by lymphocytes (in vitro) was investigated. The ellagitannic fraction revealed concentration-dependent cytotoxicity. The alkaloid fraction in concentrations less than 0.2 mg/ml caused an increase in the proliferation of lymphocytes and stimulated the cytokine production. In higher concentrations both alkaloid and ellagitannic fractions showed cytotoxic effect.

Original languageEnglish
Title of host publicationProceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology
Subtitle of host publication7th Korea-Russia International Symposium on Science and Technology
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages18-21
Number of pages4
Volume4
ISBN (Electronic)8978686206, 9788978686204
Publication statusPublished - 2003
Externally publishedYes
Event7th Korea-Russia International Symposium on Science and Technology, KORUS 2003 - Ulsan, Korea, Republic of
Duration: 28 Jun 20036 Jul 2003

Conference

Conference7th Korea-Russia International Symposium on Science and Technology, KORUS 2003
CountryKorea, Republic of
CityUlsan
Period28.6.036.7.03

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Keywords

  • Alkaloids
  • Cytokine production
  • Fractionation
  • Lymphocyte proliferation
  • Sea buckthorn bark
  • Tannins

ASJC Scopus subject areas

  • Building and Construction
  • Pollution
  • Biotechnology
  • Social Sciences (miscellaneous)
  • Medicine (miscellaneous)
  • Education

Cite this

Chernov, M., Schepetkin, I., Ah, S. Y., Khlebnikov, A. I., Klubachuk, O., & Kwon, B. S. (2003). Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity. In Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology: 7th Korea-Russia International Symposium on Science and Technology (Vol. 4, pp. 18-21). [1222885] Institute of Electrical and Electronics Engineers Inc..