Abstract
Sea buckthorn (Hippophae Rhamnoides L.) is widespread in Altai region of Russia. For centuries this plant is used as a medicinal agent. In the present work separation of water extract of sea buckthorn bark into the ellagitannic and alkaloid fractions was carried out and influence of these fractions on the lymphocyte proliferation and cytokine production by lymphocytes (in vitro) was investigated. The ellagitannic fraction revealed concentration-dependent cytotoxicity. The alkaloid fraction in concentrations less than 0.2 mg/ml caused an increase in the proliferation of lymphocytes and stimulated the cytokine production. In higher concentrations both alkaloid and ellagitannic fractions showed cytotoxic effect.
| Original language | English |
|---|---|
| Title of host publication | Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology |
| Subtitle of host publication | 7th Korea-Russia International Symposium on Science and Technology |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 18-21 |
| Number of pages | 4 |
| Volume | 4 |
| ISBN (Electronic) | 8978686206, 9788978686204 |
| Publication status | Published - 2003 |
| Externally published | Yes |
| Event | 7th Korea-Russia International Symposium on Science and Technology, KORUS 2003 - Ulsan, Korea, Republic of Duration: 28 Jun 2003 → 6 Jul 2003 |
Conference
| Conference | 7th Korea-Russia International Symposium on Science and Technology, KORUS 2003 |
|---|---|
| Country | Korea, Republic of |
| City | Ulsan |
| Period | 28.6.03 → 6.7.03 |
Fingerprint
Keywords
- Alkaloids
- Cytokine production
- Fractionation
- Lymphocyte proliferation
- Sea buckthorn bark
- Tannins
ASJC Scopus subject areas
- Building and Construction
- Pollution
- Biotechnology
- Social Sciences (miscellaneous)
- Medicine (miscellaneous)
- Education
Cite this
Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity. / Chernov, Mikhail; Schepetkin, Igor; Ah, Shin Young; Khlebnikov, Andrey Ivanovich; Klubachuk, Olesya; Kwon, Byoung Se.
Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology: 7th Korea-Russia International Symposium on Science and Technology. Vol. 4 Institute of Electrical and Electronics Engineers Inc., 2003. p. 18-21 1222885.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Ellagitannins and alkaloids from Hippophae Rhamnoides bark and their biological activity
AU - Chernov, Mikhail
AU - Schepetkin, Igor
AU - Ah, Shin Young
AU - Khlebnikov, Andrey Ivanovich
AU - Klubachuk, Olesya
AU - Kwon, Byoung Se
PY - 2003
Y1 - 2003
N2 - Sea buckthorn (Hippophae Rhamnoides L.) is widespread in Altai region of Russia. For centuries this plant is used as a medicinal agent. In the present work separation of water extract of sea buckthorn bark into the ellagitannic and alkaloid fractions was carried out and influence of these fractions on the lymphocyte proliferation and cytokine production by lymphocytes (in vitro) was investigated. The ellagitannic fraction revealed concentration-dependent cytotoxicity. The alkaloid fraction in concentrations less than 0.2 mg/ml caused an increase in the proliferation of lymphocytes and stimulated the cytokine production. In higher concentrations both alkaloid and ellagitannic fractions showed cytotoxic effect.
AB - Sea buckthorn (Hippophae Rhamnoides L.) is widespread in Altai region of Russia. For centuries this plant is used as a medicinal agent. In the present work separation of water extract of sea buckthorn bark into the ellagitannic and alkaloid fractions was carried out and influence of these fractions on the lymphocyte proliferation and cytokine production by lymphocytes (in vitro) was investigated. The ellagitannic fraction revealed concentration-dependent cytotoxicity. The alkaloid fraction in concentrations less than 0.2 mg/ml caused an increase in the proliferation of lymphocytes and stimulated the cytokine production. In higher concentrations both alkaloid and ellagitannic fractions showed cytotoxic effect.
KW - Alkaloids
KW - Cytokine production
KW - Fractionation
KW - Lymphocyte proliferation
KW - Sea buckthorn bark
KW - Tannins
UR - http://www.scopus.com/inward/record.url?scp=84944313922&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944313922&partnerID=8YFLogxK
M3 - Conference contribution
VL - 4
SP - 18
EP - 21
BT - Proceedings - KORUS 2003: 7th Korea-Russia International Symposium on Science and Technology
PB - Institute of Electrical and Electronics Engineers Inc.
ER -