Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon

I. A. Khlusov, E. V. Kibler, V. L. Kudryavtseva, S. I. Tverdokhlebov, E. N. Bolbasov, V. V. Botvin, A. D. Latypov, N. D. Gazatova, L. S. Litvinova, V. M. Buznik, E. L. Choynzonov

Research output: Contribution to journalArticle

Abstract

Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalDoklady Chemistry
Volume484
Issue number2
DOIs
Publication statusPublished - 1 Aug 2019

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Interferons
Capsules
Copolymers
Molecules
Structural integrity
Tumors
Microscopic examination
Cells
Scanning
Electrons
Lasers
Chemical analysis
Pharmaceutical Preparations
dilactide

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon. / Khlusov, I. A.; Kibler, E. V.; Kudryavtseva, V. L.; Tverdokhlebov, S. I.; Bolbasov, E. N.; Botvin, V. V.; Latypov, A. D.; Gazatova, N. D.; Litvinova, L. S.; Buznik, V. M.; Choynzonov, E. L.

In: Doklady Chemistry, Vol. 484, No. 2, 01.08.2019, p. 74-78.

Research output: Contribution to journalArticle

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AU - Khlusov, I. A.

AU - Kibler, E. V.

AU - Kudryavtseva, V. L.

AU - Tverdokhlebov, S. I.

AU - Bolbasov, E. N.

AU - Botvin, V. V.

AU - Latypov, A. D.

AU - Gazatova, N. D.

AU - Litvinova, L. S.

AU - Buznik, V. M.

AU - Choynzonov, E. L.

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AB - Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.

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