Abstract
Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.
| Original language | English |
|---|---|
| Pages (from-to) | 74-78 |
| Number of pages | 5 |
| Journal | Doklady Chemistry |
| Volume | 484 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Aug 2019 |
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- Chemistry(all)
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Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon. / Khlusov, I. A.; Kibler, E. V.; Kudryavtseva, V. L.; Tverdokhlebov, S. I.; Bolbasov, E. N.; Botvin, V. V.; Latypov, A. D.; Gazatova, N. D.; Litvinova, L. S.; Buznik, V. M.; Choynzonov, E. L.
In: Doklady Chemistry, Vol. 484, No. 2, 01.08.2019, p. 74-78.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon
AU - Khlusov, I. A.
AU - Kibler, E. V.
AU - Kudryavtseva, V. L.
AU - Tverdokhlebov, S. I.
AU - Bolbasov, E. N.
AU - Botvin, V. V.
AU - Latypov, A. D.
AU - Gazatova, N. D.
AU - Litvinova, L. S.
AU - Buznik, V. M.
AU - Choynzonov, E. L.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.
AB - Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.
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U2 - 10.1134/S0012500819020095
DO - 10.1134/S0012500819020095
M3 - Article
AN - SCOPUS:85064600383
VL - 484
SP - 74
EP - 78
JO - Doklady Chemistry
JF - Doklady Chemistry
SN - 0012-5008
IS - 2
ER -