Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon

Abstract

Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.

Original language	English
Pages (from-to)	74-78
Number of pages	5
Journal	Doklady Chemistry
Volume	484
Issue number	2
DOIs	https://doi.org/10.1134/S0012500819020095
Publication status	Published - 1 Aug 2019

ASJC Scopus subject areas

Chemistry(all)

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10.1134/S0012500819020095

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Khlusov, I. A., Kibler, E. V., Kudryavtseva, V. L., Tverdokhlebov, S. I., Bolbasov, E. N., Botvin, V. V., Latypov, A. D., Gazatova, N. D., Litvinova, L. S., Buznik, V. M., & Choynzonov, E. L. (2019). Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon. Doklady Chemistry, 484(2), 74-78. https://doi.org/10.1134/S0012500819020095

Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon. / Khlusov, I. A.; Kibler, E. V.; Kudryavtseva, V. L.; Tverdokhlebov, S. I.; Bolbasov, E. N.; Botvin, V. V.; Latypov, A. D.; Gazatova, N. D.; Litvinova, L. S.; Buznik, V. M.; Choynzonov, E. L.

In: Doklady Chemistry, Vol. 484, No. 2, 01.08.2019, p. 74-78.

Research output: Contribution to journal › Article

Khlusov, I. A. ; Kibler, E. V. ; Kudryavtseva, V. L. ; Tverdokhlebov, S. I. ; Bolbasov, E. N. ; Botvin, V. V. ; Latypov, A. D. ; Gazatova, N. D. ; Litvinova, L. S. ; Buznik, V. M. ; Choynzonov, E. L. / Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon. In: Doklady Chemistry. 2019 ; Vol. 484, No. 2. pp. 74-78.

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title = "Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon",

abstract = "Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.",

author = "Khlusov, {I. A.} and Kibler, {E. V.} and Kudryavtseva, {V. L.} and Tverdokhlebov, {S. I.} and Bolbasov, {E. N.} and Botvin, {V. V.} and Latypov, {A. D.} and Gazatova, {N. D.} and Litvinova, {L. S.} and Buznik, {V. M.} and Choynzonov, {E. L.}",

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T1 - Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon

AU - Khlusov, I. A.

AU - Kibler, E. V.

AU - Kudryavtseva, V. L.

AU - Tverdokhlebov, S. I.

AU - Bolbasov, E. N.

AU - Botvin, V. V.

AU - Latypov, A. D.

AU - Gazatova, N. D.

AU - Litvinova, L. S.

AU - Buznik, V. M.

AU - Choynzonov, E. L.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.

AB - Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.

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