Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon

I. A. Khlusov, E. V. Kibler, V. L. Kudryavtseva, S. I. Tverdokhlebov, E. N. Bolbasov, V. V. Botvin, A. D. Latypov, N. D. Gazatova, L. S. Litvinova, V. M. Buznik, E. L. Choynzonov

Research output: Contribution to journal › Article

Abstract

Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.

Original language	English
Pages (from-to)	74-78
Number of pages	5
Journal	Doklady Chemistry
Volume	484
Issue number	2
DOIs	https://doi.org/10.1134/S0012500819020095
Publication status	Published - 1 Aug 2019

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Khlusov, I. A., Kibler, E. V., Kudryavtseva, V. L., Tverdokhlebov, S. I., Bolbasov, E. N., Botvin, V. V., ... Choynzonov, E. L. (2019). Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon. Doklady Chemistry, 484(2), 74-78. https://doi.org/10.1134/S0012500819020095

Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon. / Khlusov, I. A.; Kibler, E. V.; Kudryavtseva, V. L.; Tverdokhlebov, S. I.; Bolbasov, E. N.; Botvin, V. V.; Latypov, A. D.; Gazatova, N. D.; Litvinova, L. S.; Buznik, V. M.; Choynzonov, E. L.

In: Doklady Chemistry, Vol. 484, No. 2, 01.08.2019, p. 74-78.

Research output: Contribution to journal › Article

Khlusov, I. A. ; Kibler, E. V. ; Kudryavtseva, V. L. ; Tverdokhlebov, S. I. ; Bolbasov, E. N. ; Botvin, V. V. ; Latypov, A. D. ; Gazatova, N. D. ; Litvinova, L. S. ; Buznik, V. M. ; Choynzonov, E. L. / Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon. In: Doklady Chemistry. 2019 ; Vol. 484, No. 2. pp. 74-78.

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abstract = "Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.",

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AU - Khlusov, I. A.

AU - Kibler, E. V.

AU - Kudryavtseva, V. L.

AU - Tverdokhlebov, S. I.

AU - Bolbasov, E. N.

AU - Botvin, V. V.

AU - Latypov, A. D.

AU - Gazatova, N. D.

AU - Litvinova, L. S.

AU - Buznik, V. M.

AU - Choynzonov, E. L.

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N2 - Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.

AB - Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.

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10.1134/S0012500819020095