Abstract
Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.
Original language | English |
---|---|
Pages (from-to) | 74-78 |
Number of pages | 5 |
Journal | Doklady Chemistry |
Volume | 484 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Aug 2019 |
ASJC Scopus subject areas
- Chemistry(all)