Electron microscopy of rat liver after intravenous injection of nanosized magnetite suspension

I. V. Mil'to, I. V. Sukhodolo, A. A. Miller

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    Rat liver was examined by transmission electron microscopy after a single intravenous injection of nanosized magnetite suspension (0.1 g (Fe 3O4)/kg body weight). Magnetite particles were found in Kupffer's cells and hepatocytes. Accumulation of the particles by these two cell types was different. Morphometry of magnetite-containing granules in Kupffer's cells and nanoparticle agglomerations in hepatocytes was carried out. The ultrastructure of Kupffer's cell granules was described and the mechanism of penetration of nanosized magnetite particles into the cells was suggested. Nanosized magnetite particles were not completely eliminated over 40 days after a single injection.

    Original languageEnglish
    Pages (from-to)519-522
    Number of pages4
    JournalBulletin of Experimental Biology and Medicine
    Volume153
    Issue number4
    DOIs
    Publication statusPublished - Aug 2012

    Keywords

    • Hepatocyte
    • Kupffer's cell (stellate macrophage)
    • Magnetite nanoparticles

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

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