Elektrochemické stanovení homovanilové, vanilmandlové a 5-hydroxy-3-indoloctové kyseliny jako biomarkerů nádorových onemocnění

Translated title of the contribution: Electrochemical methods for the determination of homovanillic, vanillylmandelic, and 5-hydroxy-3-indoleacetic acid as cancer biomarkers

Anna Makrlíková, Jiří Barek, Vlastimil Vyskočil, Tomáš Navrátil

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Homovanillic (HVA), vanillylmandelic (VMA), and 5-hydroxy-3-indoleacetic acid (HIAA) are cancer biomarkers and their abnormally high urinary levels can serve as a useful tool for prediction of neuroblastoma, pheochromocytoma, and carcinoid tumors. HVA and VMA are connected with the catecholamine metabolism, while HIAA is related to the tryptophan metabolism. The aim of this review is to describe the electrochemical oxidation HVA, VMA, and HIAA and summarize published voltammetric and amperometric methods suitable for the determination of these biomarkers in various biological fluids.

Original languageCzech
Pages (from-to)605-615
Number of pages11
JournalChemicke Listy
Volume112
Issue number9
Publication statusPublished - 15 Sep 2018
Externally publishedYes

Fingerprint

Hydroxyindoleacetic Acid
Tumor Biomarkers
Metabolism
Electrochemical oxidation
Biomarkers
Tryptophan
Catecholamines
Tumors
Fluids
indoleacetic acid

Keywords

  • 5-hydroxy-3-indoleacetic acid
  • Amperometry
  • Homovanillic acid
  • Hplc with electrochemical detection
  • Tumor biomarkers
  • Vanillylmandelic acid
  • Voltam-metry

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Elektrochemické stanovení homovanilové, vanilmandlové a 5-hydroxy-3-indoloctové kyseliny jako biomarkerů nádorových onemocnění. / Makrlíková, Anna; Barek, Jiří; Vyskočil, Vlastimil; Navrátil, Tomáš.

In: Chemicke Listy, Vol. 112, No. 9, 15.09.2018, p. 605-615.

Research output: Contribution to journalArticle

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